HLA-multiple sclerosis association in Continental Italy and correlation with disease prevalence in Europe

Clara Ballerini; Franca R. Guerini; Giovanni Rombolà; Eleonora Rosati; Luca Massacesi; Pasquale Ferrante; Domenico Caputo; Lorenzo Figà Talamanca; Paola Naldi; Maria Liguori; Mehdi Alizadeh; Patricia Momigliano-Richiardi; Sandra D'Alfonso

doi:10.1016/j.jneuroim.2004.01.015

HLA-multiple sclerosis association in Continental Italy and correlation with disease prevalence in Europe

Clara Ballerini, Franca R. Guerini, Giovanni Rombolà, Eleonora Rosati, Luca Massacesi, Pasquale Ferrante, Domenico Caputo, Lorenzo Figà Talamanca, Paola Naldi, Maria Liguori, Mehdi Alizadeh, Patricia Momigliano-Richiardi, Sandra D'Alfonso

Dipartimento di Scienze della Salute

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

The association with HLA-DRB1 alleles was tested in 609 Continental Italian MS patients and 836 controls. The phenotype frequency of DRB1*15 in the patients was significantly higher (0.316 vs. 0.112; p_c<10 ^-6; Odds Ratio (OR)=3.64) with no dose effect. DRB1*10 was also significantly increased (OR=2.19; p_c=0.047) and DRB1*07 decreased (OR=0.60; p_c=1.3×10^-3) independently of DR15 and of each other. We did not detect an influence of the DR phenotype on disease course, age at onset/diagnosis, gender or familiarity. No association with Class I was detected in a random subset of patients and controls. A comparison of the HLA association data in Northern and Southern European populations shows a parallel between disease prevalence and DR15 frequency.

Lingua originale	Inglese
pagine (da-a)	178-185
Numero di pagine	8
Rivista	Journal of Neuroimmunology
Volume	150
Numero di pubblicazione	1-2
DOI	https://doi.org/10.1016/j.jneuroim.2004.01.015
Stato di pubblicazione	Pubblicato - mag 2004

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10.1016/j.jneuroim.2004.01.015

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Ballerini, C., Guerini, F. R., Rombolà, G., Rosati, E., Massacesi, L., Ferrante, P., Caputo, D., Talamanca, L. F., Naldi, P., Liguori, M., Alizadeh, M., Momigliano-Richiardi, P., & D'Alfonso, S. (2004). HLA-multiple sclerosis association in Continental Italy and correlation with disease prevalence in Europe. Journal of Neuroimmunology, 150(1-2), 178-185. https://doi.org/10.1016/j.jneuroim.2004.01.015

@article{3d3407a9de384ec0b8a3f6ad306c2e90,

title = "HLA-multiple sclerosis association in Continental Italy and correlation with disease prevalence in Europe",

abstract = "The association with HLA-DRB1 alleles was tested in 609 Continental Italian MS patients and 836 controls. The phenotype frequency of DRB1*15 in the patients was significantly higher (0.316 vs. 0.112; pc<10 -6; Odds Ratio (OR)=3.64) with no dose effect. DRB1*10 was also significantly increased (OR=2.19; pc=0.047) and DRB1*07 decreased (OR=0.60; pc=1.3×10-3) independently of DR15 and of each other. We did not detect an influence of the DR phenotype on disease course, age at onset/diagnosis, gender or familiarity. No association with Class I was detected in a random subset of patients and controls. A comparison of the HLA association data in Northern and Southern European populations shows a parallel between disease prevalence and DR15 frequency.",

keywords = "HLA, Multiple sclerosis",

author = "Clara Ballerini and Guerini, {Franca R.} and Giovanni Rombol{\`a} and Eleonora Rosati and Luca Massacesi and Pasquale Ferrante and Domenico Caputo and Talamanca, {Lorenzo Fig{\`a}} and Paola Naldi and Maria Liguori and Mehdi Alizadeh and Patricia Momigliano-Richiardi and Sandra D'Alfonso",

note = "Funding Information: This work was financed by FISM (Italian Foundation for Multiple Sclerosis). We are grateful to the patients and to their families. The helpful criticism of Dr. Roberto Tosi is gratefully acknowledged.",

year = "2004",

month = may,

doi = "10.1016/j.jneuroim.2004.01.015",

language = "English",

volume = "150",

pages = "178--185",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

publisher = "Elsevier B.V.",

number = "1-2",

}

Ballerini, C, Guerini, FR, Rombolà, G, Rosati, E, Massacesi, L, Ferrante, P, Caputo, D, Talamanca, LF, Naldi, P, Liguori, M, Alizadeh, M, Momigliano-Richiardi, P & D'Alfonso, S 2004, 'HLA-multiple sclerosis association in Continental Italy and correlation with disease prevalence in Europe', Journal of Neuroimmunology, vol. 150, n. 1-2, pagg. 178-185. https://doi.org/10.1016/j.jneuroim.2004.01.015

TY - JOUR

T1 - HLA-multiple sclerosis association in Continental Italy and correlation with disease prevalence in Europe

AU - Ballerini, Clara

AU - Guerini, Franca R.

AU - Rombolà, Giovanni

AU - Rosati, Eleonora

AU - Massacesi, Luca

AU - Ferrante, Pasquale

AU - Caputo, Domenico

AU - Talamanca, Lorenzo Figà

AU - Naldi, Paola

AU - Liguori, Maria

AU - Alizadeh, Mehdi

AU - Momigliano-Richiardi, Patricia

AU - D'Alfonso, Sandra

N1 - Funding Information: This work was financed by FISM (Italian Foundation for Multiple Sclerosis). We are grateful to the patients and to their families. The helpful criticism of Dr. Roberto Tosi is gratefully acknowledged.

PY - 2004/5

Y1 - 2004/5

N2 - The association with HLA-DRB1 alleles was tested in 609 Continental Italian MS patients and 836 controls. The phenotype frequency of DRB1*15 in the patients was significantly higher (0.316 vs. 0.112; pc<10 -6; Odds Ratio (OR)=3.64) with no dose effect. DRB1*10 was also significantly increased (OR=2.19; pc=0.047) and DRB1*07 decreased (OR=0.60; pc=1.3×10-3) independently of DR15 and of each other. We did not detect an influence of the DR phenotype on disease course, age at onset/diagnosis, gender or familiarity. No association with Class I was detected in a random subset of patients and controls. A comparison of the HLA association data in Northern and Southern European populations shows a parallel between disease prevalence and DR15 frequency.

AB - The association with HLA-DRB1 alleles was tested in 609 Continental Italian MS patients and 836 controls. The phenotype frequency of DRB1*15 in the patients was significantly higher (0.316 vs. 0.112; pc<10 -6; Odds Ratio (OR)=3.64) with no dose effect. DRB1*10 was also significantly increased (OR=2.19; pc=0.047) and DRB1*07 decreased (OR=0.60; pc=1.3×10-3) independently of DR15 and of each other. We did not detect an influence of the DR phenotype on disease course, age at onset/diagnosis, gender or familiarity. No association with Class I was detected in a random subset of patients and controls. A comparison of the HLA association data in Northern and Southern European populations shows a parallel between disease prevalence and DR15 frequency.

KW - HLA

KW - Multiple sclerosis

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U2 - 10.1016/j.jneuroim.2004.01.015

DO - 10.1016/j.jneuroim.2004.01.015

M3 - Article

SN - 0165-5728

VL - 150

SP - 178

EP - 185

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 1-2

ER -

HLA-multiple sclerosis association in Continental Italy and correlation with disease prevalence in Europe

Abstract

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