High Mobility Group Box Protein-1 in Wound Repair

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

High-mobility group box 1 protein (HMGB1), a member of highly conserved non-histone DNA binding protein family, has been studied as transcription factor and growth factor. Secreted extracellularly by activated monocytes and macrophages or passively released by necrotic or damaged cells, extracellular HMGB1 is a potent mediator of inflammation. Extracellular HMGB1 has apparently contrasting biological actions: it sustains inflammation (with the possible establishment of autoimmunity or of self-maintaining tissue damage), but it also activates and recruits stem cells, boosting tissue repair. Here, we focus on the role of HMGB1 in physiological and pathological responses, the mechanisms by which it contributes to tissue repair and therapeutic strategies base on targeting HMGB1.
Lingua originaleInglese
pagine (da-a)669-710
Numero di pagine42
RivistaCells
Volume1
Numero di pubblicazione4
DOI
Stato di pubblicazionePubblicato - 1 gen 2012

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