Abstract
Kinetic inertness is a key property for a Gd-based contrast agent. The GdIII complex of a cyclohexyl-fused AAZTA derivative shows the highest kinetic inertness for non-macrocyclic bis hydrated (q = 2) GdIII-complexes with a dissociation half-life of 91 years under physiological conditions, very close to that of macrocyclic clinically approved contrast agents. It also shows optimal relaxometric performance (r1 = 8.3 mM-1 s-1 at 20 MHz and 25 °C) due to the presence of two inner sphere water molecules in fast exchange with bulk water and not displaced by endogenous anions.
Lingua originale | Inglese |
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pagine (da-a) | 11235-11238 |
Numero di pagine | 4 |
Rivista | Chemical Communications |
Volume | 52 |
Numero di pubblicazione | 75 |
DOI | |
Stato di pubblicazione | Pubblicato - 2016 |