High-Density Lipoproteins and Coronary Artery Disease: A Single-Center Cohort Study

Alon Schaffer, Monica Verdoia, Lucia Barbieri, Toni Mustahsani Aprami, Harry Suryapranata, Paolo Marino, Giuseppe De Luca

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

Our goal was to estimate the role of high-density lipoprotein cholesterol (HDL-C) in predicting the prevalence and extent of coronary artery disease (CAD) in 3280 patients undergoing coronary angiography. Predictors of lower HDL levels (<32 mg/dL) were male gender (P <.001), diabetes mellitus (P =.03), renal failure (P =.01), higher low-density lipoprotein and total cholesterol (P <.001, respectively), triglycerides (P <.001), and white blood cells (P <.001), aging (P <.001), previous myocardial infarction (P =.02) and hemoglobin (P <.001), treatment with angiotensin-receptor blockers (P <.001), and statins (P =.002). The HDL-C levels were significantly inversely associated with prevalence of CAD (P <.001, adjusted odds ratio [OR] [95% confidence interval, CI] = 1.35 [1.25-1.45], P <.001), and HDL-C <44 mg/dL was best the predictive value of the risk of CAD, (adjusted OR [95%CI] = 1.61 [1.24-2.1], P <.001). We found significant association between HDL-C and the risk of CAD; a value <44 mg/dL was the best cutoff in the prediction of CAD.

Lingua originaleInglese
pagine (da-a)696-702
Numero di pagine7
RivistaAngiology
Volume65
Numero di pubblicazione8
DOI
Stato di pubblicazionePubblicato - set 2014
Pubblicato esternamente

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