TY - JOUR
T1 - High-Density Lipoproteins and Coronary Artery Disease
T2 - A Single-Center Cohort Study
AU - Schaffer, Alon
AU - Verdoia, Monica
AU - Barbieri, Lucia
AU - Aprami, Toni Mustahsani
AU - Suryapranata, Harry
AU - Marino, Paolo
AU - Luca, Giuseppe De
PY - 2014/9
Y1 - 2014/9
N2 - Our goal was to estimate the role of high-density lipoprotein cholesterol (HDL-C) in predicting the prevalence and extent of coronary artery disease (CAD) in 3280 patients undergoing coronary angiography. Predictors of lower HDL levels (<32 mg/dL) were male gender (P <.001), diabetes mellitus (P =.03), renal failure (P =.01), higher low-density lipoprotein and total cholesterol (P <.001, respectively), triglycerides (P <.001), and white blood cells (P <.001), aging (P <.001), previous myocardial infarction (P =.02) and hemoglobin (P <.001), treatment with angiotensin-receptor blockers (P <.001), and statins (P =.002). The HDL-C levels were significantly inversely associated with prevalence of CAD (P <.001, adjusted odds ratio [OR] [95% confidence interval, CI] = 1.35 [1.25-1.45], P <.001), and HDL-C <44 mg/dL was best the predictive value of the risk of CAD, (adjusted OR [95%CI] = 1.61 [1.24-2.1], P <.001). We found significant association between HDL-C and the risk of CAD; a value <44 mg/dL was the best cutoff in the prediction of CAD.
AB - Our goal was to estimate the role of high-density lipoprotein cholesterol (HDL-C) in predicting the prevalence and extent of coronary artery disease (CAD) in 3280 patients undergoing coronary angiography. Predictors of lower HDL levels (<32 mg/dL) were male gender (P <.001), diabetes mellitus (P =.03), renal failure (P =.01), higher low-density lipoprotein and total cholesterol (P <.001, respectively), triglycerides (P <.001), and white blood cells (P <.001), aging (P <.001), previous myocardial infarction (P =.02) and hemoglobin (P <.001), treatment with angiotensin-receptor blockers (P <.001), and statins (P =.002). The HDL-C levels were significantly inversely associated with prevalence of CAD (P <.001, adjusted odds ratio [OR] [95% confidence interval, CI] = 1.35 [1.25-1.45], P <.001), and HDL-C <44 mg/dL was best the predictive value of the risk of CAD, (adjusted OR [95%CI] = 1.61 [1.24-2.1], P <.001). We found significant association between HDL-C and the risk of CAD; a value <44 mg/dL was the best cutoff in the prediction of CAD.
KW - coronary angiography
KW - coronary artery disease
KW - high-density lipoprotein
UR - http://www.scopus.com/inward/record.url?scp=84905905153&partnerID=8YFLogxK
U2 - 10.1177/0003319713502253
DO - 10.1177/0003319713502253
M3 - Article
SN - 0003-3197
VL - 65
SP - 696
EP - 702
JO - Angiology
JF - Angiology
IS - 8
ER -