Hepatobiliary scintigraphy allows the evaluation of short-term functional toxicity of liver stereotactic body radiotherapy: Results of a pilot study

Berardino De Bari, Thomas Breuneval, Michele Zeverino, Sarah Godin, Letizia Deantonio, Christine Geldhof, Jean Bourhis, Nicklaus Schaefer, Raphael Moeckli, John Prior, Mahmut Ozsahin

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

Purpose To study the potential of (99m)Tc-Mebrofenin hepatobiliary scintigraphy (HBS) in identifying the short-term variations of liver function after stereotactic body radiotherapy (SBRT) for liver cancers. Material and methods We treated with SBRT 3 patients (pts) affected by a cholangiocarcinoma and 3 patient presenting liver metastases (3x15 Gy, 4 pts; 5x8 Gy, 1 pt; 6x5 Gy, 1 pt). All patients received HBS before and 3 months after SBRT, which were co-registered with the simulation CTscan. Structures corresponding to isodoses from 10-90 Gy were created, with intervals of 10 Gy. Finally, the variations of the mean activity (MBq) in each isodose structure have been calculated. Then, a linear regression analysis was performed. Results We showed a linear reduction of the activity, significantly related to the delivered dose (p<0.01), and a reduction of the perfusion of 0.78% for each delivered Gy. The linear equation has predictive value of the loss of the function of 96% (R2 = 0.9605). Conclusions HBS could improve treatment plans for liver SBRT, by allowing the identification of the liver function variations after SBRT and, potentially, the prediction of remnant liver function after SBRT. These preliminary results should be confirmed on long-term prospective data and larger population.

Lingua originaleInglese
Numero di articoloe0204013
RivistaPLoS ONE
Volume13
Numero di pubblicazione10
DOI
Stato di pubblicazionePubblicato - ott 2018
Pubblicato esternamente

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