Hairy cell leukaemia complicated by anti-MAG paraproteinemic demyelinating neuropathy: resolution of neurological syndrome after cladribrine treatment

Davide Rossi; Silvia Franceschetti; Michaela Cerri; Annarita Conconi; Monia Lunghi; Daniela Capello; Roberto Cantello; Gianluca Gaidano

doi:10.1016/j.leukres.2006.08.020

Hairy cell leukaemia complicated by anti-MAG paraproteinemic demyelinating neuropathy: resolution of neurological syndrome after cladribrine treatment

Davide Rossi, Silvia Franceschetti, Michaela Cerri, Annarita Conconi, Monia Lunghi, Daniela Capello, Roberto Cantello, Gianluca Gaidano

Dipartimento di Medicina Traslazionale

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Hairy cell leukaemia (HCL) occasionally displays a monoclonal gammopathy, yet the association of HCL with paraproteinemic demyelinating neuropathy (PDN) has not been reported. We describe a HCL case complicated by PDN and high titers of monoclonal IgM against myelin associated glycoprotein (MAG). Heavy and light chains of the patient's anti-MAG monoclonal protein were consistent with those expressed by HCL cells. After treatment with cladribrine, remission of HCL strictly paralleled disappearance of the IgM monoclonal protein and of the serum anti-MAG activity, and led to PDN clinical and electrophysiological improvement. Purine analogs may represent a choice in IgM PDN associated with lymphoproliferative disorders.

Lingua originale	Inglese
pagine (da-a)	873-876
Numero di pagine	4
Rivista	Leukemia Research
Volume	31
Numero di pubblicazione	6
DOI	https://doi.org/10.1016/j.leukres.2006.08.020
Stato di pubblicazione	Pubblicato - giu 2007

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10.1016/j.leukres.2006.08.020

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title = "Hairy cell leukaemia complicated by anti-MAG paraproteinemic demyelinating neuropathy: resolution of neurological syndrome after cladribrine treatment",

abstract = "Hairy cell leukaemia (HCL) occasionally displays a monoclonal gammopathy, yet the association of HCL with paraproteinemic demyelinating neuropathy (PDN) has not been reported. We describe a HCL case complicated by PDN and high titers of monoclonal IgM against myelin associated glycoprotein (MAG). Heavy and light chains of the patient's anti-MAG monoclonal protein were consistent with those expressed by HCL cells. After treatment with cladribrine, remission of HCL strictly paralleled disappearance of the IgM monoclonal protein and of the serum anti-MAG activity, and led to PDN clinical and electrophysiological improvement. Purine analogs may represent a choice in IgM PDN associated with lymphoproliferative disorders.",

keywords = "Cladribine, Hairy cell leukaemia, IgM paraprotein, Myelin associated glycoprotein, Paraproteinemic demyelinating neuropathy",

author = "Davide Rossi and Silvia Franceschetti and Michaela Cerri and Annarita Conconi and Monia Lunghi and Daniela Capello and Roberto Cantello and Gianluca Gaidano",

year = "2007",

month = jun,

doi = "10.1016/j.leukres.2006.08.020",

language = "English",

volume = "31",

pages = "873--876",

journal = "Leukemia Research",

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TY - JOUR

T1 - Hairy cell leukaemia complicated by anti-MAG paraproteinemic demyelinating neuropathy

T2 - resolution of neurological syndrome after cladribrine treatment

AU - Rossi, Davide

AU - Franceschetti, Silvia

AU - Cerri, Michaela

AU - Conconi, Annarita

AU - Lunghi, Monia

AU - Capello, Daniela

AU - Cantello, Roberto

AU - Gaidano, Gianluca

PY - 2007/6

Y1 - 2007/6

N2 - Hairy cell leukaemia (HCL) occasionally displays a monoclonal gammopathy, yet the association of HCL with paraproteinemic demyelinating neuropathy (PDN) has not been reported. We describe a HCL case complicated by PDN and high titers of monoclonal IgM against myelin associated glycoprotein (MAG). Heavy and light chains of the patient's anti-MAG monoclonal protein were consistent with those expressed by HCL cells. After treatment with cladribrine, remission of HCL strictly paralleled disappearance of the IgM monoclonal protein and of the serum anti-MAG activity, and led to PDN clinical and electrophysiological improvement. Purine analogs may represent a choice in IgM PDN associated with lymphoproliferative disorders.

AB - Hairy cell leukaemia (HCL) occasionally displays a monoclonal gammopathy, yet the association of HCL with paraproteinemic demyelinating neuropathy (PDN) has not been reported. We describe a HCL case complicated by PDN and high titers of monoclonal IgM against myelin associated glycoprotein (MAG). Heavy and light chains of the patient's anti-MAG monoclonal protein were consistent with those expressed by HCL cells. After treatment with cladribrine, remission of HCL strictly paralleled disappearance of the IgM monoclonal protein and of the serum anti-MAG activity, and led to PDN clinical and electrophysiological improvement. Purine analogs may represent a choice in IgM PDN associated with lymphoproliferative disorders.

KW - Cladribine

KW - Hairy cell leukaemia

KW - IgM paraprotein

KW - Myelin associated glycoprotein

KW - Paraproteinemic demyelinating neuropathy

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U2 - 10.1016/j.leukres.2006.08.020

DO - 10.1016/j.leukres.2006.08.020

M3 - Article

SN - 0145-2126

VL - 31

SP - 873

EP - 876

JO - Leukemia Research

JF - Leukemia Research

IS - 6

ER -

Hairy cell leukaemia complicated by anti-MAG paraproteinemic demyelinating neuropathy: resolution of neurological syndrome after cladribrine treatment

Abstract

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