TY - JOUR
T1 - Habituation of exploratory activity in rats
T2 - Action of N6phenylisopropyladenosine, caffeine and their combination
AU - Molinengo, Luigi
AU - Orsetti, Marco
AU - Pastorello, Barbara
AU - Scordo, Isabella
AU - Ghi, Piera
PY - 1995/11
Y1 - 1995/11
N2 - 1. 1. L-PIA (0.2 mg/kg), caffeine (15 mg/kg) and their combination were given subcutaneously to rats tested in open field. 2. 2. The acute administration of L-PIA reduced ambulation. Caffeine alone was ineffective but increased ambulation in combination with L-PIA. These effects may have been determined by an interaction of L-PIA and caffeine on adenosine receptors. 3. 3. Tolerance to L-PIA was observed after a chronic administration (20 days). The chronic administration of caffeine alone or in combination with L-PIA increased ambulation. 4. 4. In the habituation test the reduction of ambulation in the 3 successive trials was increased by L-PIA. Caffeine did not antagonize the L-PIA effect and, in part, had the same effect. These results suggest that L-PIA and, in part, caffeine improve memory consolidation in open field and do not support the notion that L-PIA and caffeine action on memory processes is due to an interference on adenosine receptors.
AB - 1. 1. L-PIA (0.2 mg/kg), caffeine (15 mg/kg) and their combination were given subcutaneously to rats tested in open field. 2. 2. The acute administration of L-PIA reduced ambulation. Caffeine alone was ineffective but increased ambulation in combination with L-PIA. These effects may have been determined by an interaction of L-PIA and caffeine on adenosine receptors. 3. 3. Tolerance to L-PIA was observed after a chronic administration (20 days). The chronic administration of caffeine alone or in combination with L-PIA increased ambulation. 4. 4. In the habituation test the reduction of ambulation in the 3 successive trials was increased by L-PIA. Caffeine did not antagonize the L-PIA effect and, in part, had the same effect. These results suggest that L-PIA and, in part, caffeine improve memory consolidation in open field and do not support the notion that L-PIA and caffeine action on memory processes is due to an interference on adenosine receptors.
KW - Acute administration
KW - Caffeine
KW - Chronic administration
KW - Memory consolidation
KW - N- (l-pheny1isopropyladenosine)
KW - Open Field
UR - http://www.scopus.com/inward/record.url?scp=0029559863&partnerID=8YFLogxK
U2 - 10.1016/0278-5846(95)00236-7
DO - 10.1016/0278-5846(95)00236-7
M3 - Article
SN - 0278-5846
VL - 19
SP - 1189
EP - 1200
JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry
JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry
IS - 7
ER -