TY - JOUR
T1 - GWAS meta-analysis of 16 852 women identifies new susceptibility locus for endometrial cancer
AU - National Study Of Endometrial Cancer Genetics Group (NSECG)
AU - Australian National Endometrial Cancer Study Group (ANECS)
AU - Chen, Maxine M.
AU - O'Mara, Tracy A.
AU - Thompson, Deborah J.
AU - Painter, Jodie N.
AU - Attia, John
AU - Black, Amanda
AU - Brinton, Louise
AU - Chanock, Stephen
AU - Chen, Chu
AU - Cheng, Timothy Ht
AU - Cook, Linda S.
AU - Crous-Bou, Marta
AU - Doherty, Jennifer
AU - Friedenreich, Christine M.
AU - Garcia-Closas, Montserrat
AU - Gaudet, Mia M.
AU - Gorman, Maggie
AU - Haiman, Christopher
AU - Hankinson, Susan E.
AU - Hartge, Patricia
AU - Henderson, Brian E.
AU - Hodgson, Shirley
AU - Holliday, Elizabeth G.
AU - Horn-Ross, Pamela L.
AU - Hunter, David J.
AU - Le Marchand, Loic
AU - Liang, Xiaolin
AU - Lissowska, Jolanta
AU - Long, Jirong
AU - Lu, Lingeng
AU - Magliocco, Anthony M.
AU - Martin, Lynn
AU - McEvoy, Mark
AU - Olson, Sara H.
AU - Orlow, Irene
AU - Pooler, Loreall
AU - Prescott, Jennifer
AU - Rastogi, Radhai
AU - Rebbeck, Timothy R.
AU - Risch, Harvey
AU - Sacerdote, Carlotta
AU - Schumacher, Frederick
AU - Wendy Setiawan, Veronica
AU - Scott, Rodney J.
AU - Sheng, Xin
AU - Shu, Xiao Ou
AU - Turman, Constance
AU - Van Den Berg, David
AU - Wang, Zhaoming
AU - Weiss, Noel S.
N1 - Publisher Copyright:
© The Author 2016. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: [email protected].
PY - 2016/6/15
Y1 - 2016/6/15
N2 - Endometrial cancer is the most common gynecological malignancy in the developed world. Although there is evidence of genetic predisposition to the disease, most of the genetic risk remains unexplained. We present the meta-analysis results of four genome-wide association studies (4907 cases and 11 945 controls total) in women of European ancestry. We describe one new locus reaching genome-wide significance (P < 5 × 10 -8) at 6p22.3 (rs1740828; P = 2.29 × 10 -8, OR = 1.20), providing evidence of an additional region of interest for genetic susceptibility to endometrial cancer.
AB - Endometrial cancer is the most common gynecological malignancy in the developed world. Although there is evidence of genetic predisposition to the disease, most of the genetic risk remains unexplained. We present the meta-analysis results of four genome-wide association studies (4907 cases and 11 945 controls total) in women of European ancestry. We describe one new locus reaching genome-wide significance (P < 5 × 10 -8) at 6p22.3 (rs1740828; P = 2.29 × 10 -8, OR = 1.20), providing evidence of an additional region of interest for genetic susceptibility to endometrial cancer.
UR - http://www.scopus.com/inward/record.url?scp=85024098018&partnerID=8YFLogxK
U2 - 10.1093/hmg/ddw092
DO - 10.1093/hmg/ddw092
M3 - Article
SN - 0964-6906
VL - 25
SP - 2612
EP - 2620
JO - Human Molecular Genetics
JF - Human Molecular Genetics
IS - 12
ER -
