Gut microbiota diversity and T1DM onset: Preliminary data of a case-control study

Deborah Traversi; Ivana Rabbone; Maria Giovanna Ignaccolo; Giulia Carletto; Irene Racca; Camilla Vallini; Violetta Andriolo; Francesco Cadario; Silvia Savastio; Roberta Siliquini; Franco Cerutti

doi:10.1016/j.humic.2017.11.002

Gut microbiota diversity and T1DM onset: Preliminary data of a case-control study

Deborah Traversi, Ivana Rabbone, Maria Giovanna Ignaccolo, Giulia Carletto, Irene Racca, Camilla Vallini, Violetta Andriolo, Francesco Cadario, Silvia Savastio, Roberta Siliquini, Franco Cerutti

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Type-1 diabetes incidence is increasing during the last decades. Recently, a role of microbiota alteration is proposed as pre-diabetic and diabetic risk factor. A bicentric case-control study is in progress in Northern Italy. Here preliminary results are shown. The microbiome clusterization showed a division between cases and controls even if fingerprint profiles are heterogenic. Methanobrevibacter smithii is highly present only in few patients. The diversity index and the microorganism sequenced in cases and controls, seems to be quite dissimilar. The conclusive results could show a significant predictive value for the bio-indicators evaluated.

Lingua originale	Inglese
pagine (da-a)	11-13
Numero di pagine	3
Rivista	Human Microbiome Journal
Volume	5-6
DOI	https://doi.org/10.1016/j.humic.2017.11.002
Stato di pubblicazione	Pubblicato - dic 2017
Pubblicato esternamente	Sì

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10.1016/j.humic.2017.11.002

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title = "Gut microbiota diversity and T1DM onset: Preliminary data of a case-control study",

abstract = "Type-1 diabetes incidence is increasing during the last decades. Recently, a role of microbiota alteration is proposed as pre-diabetic and diabetic risk factor. A bicentric case-control study is in progress in Northern Italy. Here preliminary results are shown. The microbiome clusterization showed a division between cases and controls even if fingerprint profiles are heterogenic. Methanobrevibacter smithii is highly present only in few patients. The diversity index and the microorganism sequenced in cases and controls, seems to be quite dissimilar. The conclusive results could show a significant predictive value for the bio-indicators evaluated.",

keywords = "Children, Methanobrevibacter smithii, Microbiota, Type 1 diabetes mellitus, qRT-PCR",

author = "Deborah Traversi and Ivana Rabbone and Ignaccolo, {Maria Giovanna} and Giulia Carletto and Irene Racca and Camilla Vallini and Violetta Andriolo and Francesco Cadario and Silvia Savastio and Roberta Siliquini and Franco Cerutti",

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doi = "10.1016/j.humic.2017.11.002",

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AU - Traversi, Deborah

AU - Rabbone, Ivana

AU - Ignaccolo, Maria Giovanna

AU - Carletto, Giulia

AU - Racca, Irene

AU - Vallini, Camilla

AU - Andriolo, Violetta

AU - Cadario, Francesco

AU - Savastio, Silvia

AU - Siliquini, Roberta

AU - Cerutti, Franco

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AB - Type-1 diabetes incidence is increasing during the last decades. Recently, a role of microbiota alteration is proposed as pre-diabetic and diabetic risk factor. A bicentric case-control study is in progress in Northern Italy. Here preliminary results are shown. The microbiome clusterization showed a division between cases and controls even if fingerprint profiles are heterogenic. Methanobrevibacter smithii is highly present only in few patients. The diversity index and the microorganism sequenced in cases and controls, seems to be quite dissimilar. The conclusive results could show a significant predictive value for the bio-indicators evaluated.

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Gut microbiota diversity and T1DM onset: Preliminary data of a case-control study

Abstract

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