Groebke multicomponent reaction and subsequent nucleophilic aromatic substitution for a convenient synthesis of 3,8-diaminoimidazo[1,2-a]pyrazines as potential kinase inhibitors

Keyphrases

• Kinase Inhibitor 100%
• Nucleophilic Aromatic Substitution 100%
• Pyrazine 100%
• Convenient Synthesis 100%
• Multicomponent Reaction 100%
• Synthesized Compounds 50%
• Isocyanide 50%
• Protein Kinase Inhibitors 50%
• Ammonia 50%
• Secondary Amines 50%
• Primary Amines 50%
• Novel Proteins 50%

Chemistry

• Multicomponent Reaction 100%
• Nucleophilic Aromatic Substitution 100%
• Phosphotransferase Inhibitor 100%
• Isocyanide 50%
• Secondary Amine 50%
• Primary Amine 50%
• Protein Kinase Inhibitor 50%
• Ammonia 50%