Grid-based atherosclerosis simulations

FRANCESCO PAPPALARDO, MARZIO ALFIO PENNISI, E Mastriani, MOTTA Santo

Risultato della ricerca: Contributo alla conferenzaContributo in Atti di Convegnopeer review

Abstract

Atherosclerosis, a pathology affecting arterial blood vessels, is one of most common disease of the developed countries. We present studies on the increased atherosclerosis risk using an agent based model of atherogenesis that has been previously validated using clinical data. It is well known that the major risk in atheroscle- rosis is the persistent high level of low density lipoprotein (LDL) concentration. However, it is not known if short period of high LDL con- centration can cause irreversible damage and if reduction of the LDL concentration (either by life style or drug) can drastically or partially reduce the already acquired risk. We used the Sicilian Grid infrastructure to simulate three different clinical situations in a large set of virtual patients (200 per clinical scenario). In the first one the patients lifestyle maintains the concentration of LDL in a no risk range. This is the control case simulation. In the second and in the third simu- lations, the lifestyle of the virtual patients raises the LDL concentration to a risk level. Differences in the foam cells formation can be interpreted as permanent or non-permanent risk effects. Finally we consider virtual patients whose life style raises many times the level of LDL concentration just above the normal but this is quickly reduced using appropriate treatment. Those preliminary results obviously need to be clinically investigated. The Grid power allowed us to retrieve results of the simulation in a short time.
Lingua originaleInglese
Pagine396-402
Numero di pagine7
Stato di pubblicazionePubblicato - 1 gen 2009
EventoFinal Workshop of Grid Projects, PON Ricerca 2000-2006, no. 1575 - Catania
Durata: 1 gen 2009 → …

???event.eventtypes.event.conference???

???event.eventtypes.event.conference???Final Workshop of Grid Projects, PON Ricerca 2000-2006, no. 1575
CittàCatania
Periodo1/01/09 → …

Keywords

  • Agent-based model
  • GRID
  • HPC

Fingerprint

Entra nei temi di ricerca di 'Grid-based atherosclerosis simulations'. Insieme formano una fingerprint unica.

Cita questo