GM1 ganglioside stimulates the regeneration of dopaminergic neurons in the central nervous system

G. Toffano, G. Savoini, F. Moroni, G. Lombardi, L. Calza, L. F. Agnati

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

The effect of GM1 ganglioside on the recovery of nigro-strital dopaminergic neurons was studied in rats after unilateral hemitransection. We find that repeated administration of GM1 significantly increased the HVA content, the tyrosine hydroxylase activity and the tyrosine hydroxylase-related immunofluorescence in the striatum ipsilateral to the lesion. Futhermore, GM1 reduced the sensitivity of lesioned rats to apomorphine. The data comparable with the view that a functional dopaminergic reinnervation of the striatum is facilitated by GM1 treatments after hemitransection.

Lingua originaleInglese
pagine (da-a)163-166
Numero di pagine4
RivistaBrain Research
Volume261
Numero di pubblicazione1
DOI
Stato di pubblicazionePubblicato - 14 feb 1983
Pubblicato esternamente

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