Abstract
The effect of GM1 ganglioside on the recovery of nigro-strital dopaminergic neurons was studied in rats after unilateral hemitransection. We find that repeated administration of GM1 significantly increased the HVA content, the tyrosine hydroxylase activity and the tyrosine hydroxylase-related immunofluorescence in the striatum ipsilateral to the lesion. Futhermore, GM1 reduced the sensitivity of lesioned rats to apomorphine. The data comparable with the view that a functional dopaminergic reinnervation of the striatum is facilitated by GM1 treatments after hemitransection.
Lingua originale | Inglese |
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pagine (da-a) | 163-166 |
Numero di pagine | 4 |
Rivista | Brain Research |
Volume | 261 |
Numero di pubblicazione | 1 |
DOI | |
Stato di pubblicazione | Pubblicato - 14 feb 1983 |
Pubblicato esternamente | Sì |