GM1 ganglioside reduces ischemia-induced excitatory amino acid output: A microdialysis study in the gerbil hippocampus

Grazia Lombardi, Flavio Moroni

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

The effects of transient forebrain ischemia on the extracellular concentration of the excitatory amino acids glutamate and aspartate were studied in the gerbil hippocampus using microdialysis. Bilateral carotid occlusion (8 min) increased glutamate and aspartate concentration in the dialysate by 3- to 8-fold. This increase lasted 20-30 min. When the animals were pretreated with GM1 ganglioside (30 mg/kg/day, i.p., for 3 days), the ischemia induced increase of excitatory amino acids in the dialysate was significantly reduced. The results are in line with the hypothesis that systemic GM1 ganglioside administration may reduce ischemia-induced brain damage.

Lingua originaleInglese
pagine (da-a)171-174
Numero di pagine4
RivistaNeuroscience Letters
Volume134
Numero di pubblicazione2
DOI
Stato di pubblicazionePubblicato - 6 gen 1992
Pubblicato esternamente

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