TY - JOUR
T1 - Glucose, insulin and renin activity after sodium loading and depletion in Vipera aspis
AU - Masini, Maria Angela
AU - Uva, Bianca Maria
N1 - Funding Information:
The authorsa re hateful to Mr. R. Marini (Instituteo f Combaratiwe AnatomyU, niver& ojGenoua)f or carefully& owning &e p/&graphic work, and Mr. C. Grattarola( Instituteo f ComparativeA natomy, Uni-versityo f Geneva) fur technicaal ssistanceT. his investigatiown as sup-ported b a Grant from Italian Ministry _ of Scientific Research (M.U.R.S.T.-60%):
PY - 1996/3
Y1 - 1996/3
N2 - Sodium, potassium, chloride, glucose, insulin and renin activity were investigated in fasted Vipera aspis subjected for 3 days to administration of 3% NaCl 5 ml, or injection of a diuretic and water loading to produce sodium depletion. After sodium loading, plasma sodium and glucose were significantly elevated if compared with those of controls, while plasma renin-like activity and plasma insulin were depressed. The insulin and somatostatin producing cells (B- and D-cells) showed only a weak immunoreactivity, while in the glucagon producing cells (A-cells) the immunoreactivity was stronger if compared with the handled controls. After sodium depletion, plasma sodium and glucose were significantly depressed and plasma renin-like activity and plasma insulin were significantly elevated. A strong immunoreactivity was present in B- and D-cells and only a weak immunoreactivity was detectable in the A-cells. These data suggest that the secretory activity of the endocrine pancreas and kidney may be affected, in vipers, by sodium and/or volume status.
AB - Sodium, potassium, chloride, glucose, insulin and renin activity were investigated in fasted Vipera aspis subjected for 3 days to administration of 3% NaCl 5 ml, or injection of a diuretic and water loading to produce sodium depletion. After sodium loading, plasma sodium and glucose were significantly elevated if compared with those of controls, while plasma renin-like activity and plasma insulin were depressed. The insulin and somatostatin producing cells (B- and D-cells) showed only a weak immunoreactivity, while in the glucagon producing cells (A-cells) the immunoreactivity was stronger if compared with the handled controls. After sodium depletion, plasma sodium and glucose were significantly depressed and plasma renin-like activity and plasma insulin were significantly elevated. A strong immunoreactivity was present in B- and D-cells and only a weak immunoreactivity was detectable in the A-cells. These data suggest that the secretory activity of the endocrine pancreas and kidney may be affected, in vipers, by sodium and/or volume status.
KW - Vipera aspis
KW - endocrine pancreas
KW - glucose
KW - immunohistochemistry
KW - insulin
KW - renin activity
KW - sodium depletion
KW - sodium loading
UR - http://www.scopus.com/inward/record.url?scp=0030093773&partnerID=8YFLogxK
U2 - 10.1016/0742-8413(96)02038-5
DO - 10.1016/0742-8413(96)02038-5
M3 - Article
SN - 0742-8413
VL - 113
SP - 375
EP - 380
JO - Comparative Biochemistry and Physiology - C Pharmacology Toxicology and Endocrinology
JF - Comparative Biochemistry and Physiology - C Pharmacology Toxicology and Endocrinology
IS - 3
ER -