Glucometabolic Control and Anti-Transglutaminase Antibodies at Celiac Disease Onset in Type 1 Diabetes Youth

Francesca Di Candia; Francesco Maria Rosanio; Roberto Franceschi; Alessandro Fierro; Riccardo Bonfanti; Francesca Cardella; Valentino Cherubini; Giuseppe D'Annunzio; Barbara Felappi; Dario Iafusco; Brunella Iovane; Claudio Maffeis; Giulio Maltoni; Francesca Olivieri; Gabriele Olivieri; Barbara Piccini; Elvira Piccinno; Barbara Predieri; IVANA RABBONE; Maria Rossella Ricciardi; Giuseppina Salzano; Riccardo Schiaffini; Gianluca Tornese; Angela Zanfardino; Marco Marigliano; Riccardo Troncone; Riccardo Pertile; Luigi Greco; Renata Auricchio; Enza Mozzillo; null null; Francesco Gallo; Caterina Grosso; Carlo Ripoli; Fiorella De Berardinis; Susanna Coccoli; Valentina Tiberi; Sonia Toni; Maurizio Delvecchio; Rosanna Roppolo; Fortunato Lombardo; Stefano Passanisi; Bruno Bombaci; Alberto Casertano; Nicola Minuto; Marta Bassi; Evelina Maines; Silvia Savastio; Elena Inzaghi; Andrea Rigamonti; Giulio Frontino; Patrizia Bruzzi; Claudia Piona

doi:10.1210/clinem/dgaf604

Glucometabolic Control and Anti-Transglutaminase Antibodies at Celiac Disease Onset in Type 1 Diabetes Youth

Francesca Di Candia
, Francesco Maria Rosanio
, Roberto Franceschi
, Alessandro Fierro
, Riccardo Bonfanti
, Francesca Cardella
, Valentino Cherubini
, Giuseppe D'Annunzio
, Barbara Felappi
, Dario Iafusco
, Brunella Iovane
, Claudio Maffeis
, Giulio Maltoni
, Francesca Olivieri
, Gabriele Olivieri
, Barbara Piccini
, Elvira Piccinno
, Barbara Predieri
, IVANA RABBONE
, Maria Rossella Ricciardi

Giuseppina Salzano, Riccardo Schiaffini, Gianluca Tornese, Angela Zanfardino, Marco Marigliano, Riccardo Troncone, Riccardo Pertile, Luigi Greco, Renata Auricchio, Enza Mozzillo, null null, Francesco Gallo, Caterina Grosso, Carlo Ripoli, Fiorella De Berardinis, Susanna Coccoli, Valentina Tiberi, Sonia Toni, Maurizio Delvecchio, Rosanna Roppolo, Fortunato Lombardo, Stefano Passanisi, Bruno Bombaci, Alberto Casertano, Nicola Minuto, Marta Bassi, Evelina Maines, Silvia Savastio, Elena Inzaghi, Andrea Rigamonti, Giulio Frontino, Patrizia Bruzzi, Claudia Piona

Dipartimento di Scienze della Salute

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Context Anti-transglutaminase antibodies (anti-TTG IgA) titer is associated with mucosal damage in celiac disease (CD). Objective The primary focus was to correlate anti-TTG IgA titer, HbA1c when CD occurs (HbA1cCD), and Marsh grade in children and adolescents with type 1 diabetes (T1D) at the time of CD diagnosis. As secondary outcomes, we assessed the optimal anti-TTG IgA upper limit of normal (ULN) cutoff for sparing biopsy, and personal and familial autoimmunity history in the individuals with T1D and CD (T1D-CD) compared with T1D-only. Methods In this retrospective observational study, among 6933 individuals with T1D onset (2010-2019), 556 were grouped according to CD onset: before (CD_FIRST), concomitant (CD_CONCOMITANT), or after T1D (T1D_FIRST), and compared with 141 T1D without CD. Measures included HbA1cCD, fold-anti-TTG IgA, anti-TTG IgA cutoff, and autoimmunity history of both groups, as well as Marsh grade in T1D-CD. Results In youths with T1D, HbA1cCD was associated with increased fold-anti-TTG IgA (Spearman r = 0.14, P = .0047). The optimal anti-TTG IgA cutoff for sparing biopsy was 11 ULN. Autoimmunity was prevalent in T1D-CD individuals, who showed more comorbidities than controls (chi(2) 25.4, P < .001), particularly the CD_FIRST (P < .001). Conclusion In children with T1D-CD, worse glucometabolic control is associated with an increase in fold anti-TTG IgA and with worse Marsh grade. A slightly higher anti-TTG IgA cutoff may be neAcessary for sparing biopsy compared to children in the general population. Higher prevalence of autoimmune comorbidities in CD_FIRST suggests that screening for T1D in the CD population should be mandatory.

Lingua originale	Inglese
Rivista	Journal of Clinical Endocrinology and Metabolism
Volume	dgaf604
DOI	https://doi.org/10.1210/clinem/dgaf604
Stato di pubblicazione	Pubblicato - 2025

Keywords

Anti-tissue Transglutaminase
Autoimmunity
Celiac Disease
Gluten-Free Diet
Glycosylated haemoglobin
Type 1 Diabetes

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10.1210/clinem/dgaf604

https://hdl.handle.net/11579/223523

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Di Candia, F., Rosanio, F. M., Franceschi, R., Fierro, A., Bonfanti, R., Cardella, F., Cherubini, V., D'Annunzio, G., Felappi, B., Iafusco, D., Iovane, B., Maffeis, C., Maltoni, G., Olivieri, F., Olivieri, G., Piccini, B., Piccinno, E., Predieri, B., RABBONE, IVANA., ... Piona, C. (2025). Glucometabolic Control and Anti-Transglutaminase Antibodies at Celiac Disease Onset in Type 1 Diabetes Youth. Journal of Clinical Endocrinology and Metabolism, dgaf604. https://doi.org/10.1210/clinem/dgaf604

@article{be8d61a87a864d9bbc34d81f140163c0,

title = "Glucometabolic Control and Anti-Transglutaminase Antibodies at Celiac Disease Onset in Type 1 Diabetes Youth",

abstract = "Context Anti-transglutaminase antibodies (anti-TTG IgA) titer is associated with mucosal damage in celiac disease (CD). Objective The primary focus was to correlate anti-TTG IgA titer, HbA1c when CD occurs (HbA1cCD), and Marsh grade in children and adolescents with type 1 diabetes (T1D) at the time of CD diagnosis. As secondary outcomes, we assessed the optimal anti-TTG IgA upper limit of normal (ULN) cutoff for sparing biopsy, and personal and familial autoimmunity history in the individuals with T1D and CD (T1D-CD) compared with T1D-only. Methods In this retrospective observational study, among 6933 individuals with T1D onset (2010-2019), 556 were grouped according to CD onset: before (CD\_FIRST), concomitant (CD\_CONCOMITANT), or after T1D (T1D\_FIRST), and compared with 141 T1D without CD. Measures included HbA1cCD, fold-anti-TTG IgA, anti-TTG IgA cutoff, and autoimmunity history of both groups, as well as Marsh grade in T1D-CD. Results In youths with T1D, HbA1cCD was associated with increased fold-anti-TTG IgA (Spearman r = 0.14, P = .0047). The optimal anti-TTG IgA cutoff for sparing biopsy was 11 ULN. Autoimmunity was prevalent in T1D-CD individuals, who showed more comorbidities than controls (chi(2) 25.4, P < .001), particularly the CD\_FIRST (P < .001). Conclusion In children with T1D-CD, worse glucometabolic control is associated with an increase in fold anti-TTG IgA and with worse Marsh grade. A slightly higher anti-TTG IgA cutoff may be neAcessary for sparing biopsy compared to children in the general population. Higher prevalence of autoimmune comorbidities in CD\_FIRST suggests that screening for T1D in the CD population should be mandatory.",

keywords = "Anti-tissue Transglutaminase, Autoimmunity, Celiac Disease, Gluten-Free Diet, Glycosylated haemoglobin, Type 1 Diabetes, Anti-tissue Transglutaminase, Autoimmunity, Celiac Disease, Gluten-Free Diet, Glycosylated haemoglobin, Type 1 Diabetes",

author = "\{Di Candia\}, Francesca and Rosanio, \{Francesco Maria\} and Roberto Franceschi and Alessandro Fierro and Riccardo Bonfanti and Francesca Cardella and Valentino Cherubini and Giuseppe D'Annunzio and Barbara Felappi and Dario Iafusco and Brunella Iovane and Claudio Maffeis and Giulio Maltoni and Francesca Olivieri and Gabriele Olivieri and Barbara Piccini and Elvira Piccinno and Barbara Predieri and IVANA RABBONE and Ricciardi, \{Maria Rossella\} and Giuseppina Salzano and Riccardo Schiaffini and Gianluca Tornese and Angela Zanfardino and Marco Marigliano and Riccardo Troncone and Riccardo Pertile and Luigi Greco and Renata Auricchio and Enza Mozzillo and null null and Francesco Gallo and Caterina Grosso and Carlo Ripoli and \{De Berardinis\}, Fiorella and Susanna Coccoli and Valentina Tiberi and Sonia Toni and Maurizio Delvecchio and Rosanna Roppolo and Fortunato Lombardo and Stefano Passanisi and Bruno Bombaci and Alberto Casertano and Nicola Minuto and Marta Bassi and Evelina Maines and Silvia Savastio and Elena Inzaghi and Andrea Rigamonti and Giulio Frontino and Patrizia Bruzzi and Claudia Piona",

year = "2025",

doi = "10.1210/clinem/dgaf604",

language = "English",

volume = "dgaf604",

journal = "Journal of Clinical Endocrinology and Metabolism",

issn = "0021-972X",

publisher = "Endocrine Society",

}

Di Candia, F, Rosanio, FM, Franceschi, R, Fierro, A, Bonfanti, R, Cardella, F, Cherubini, V, D'Annunzio, G, Felappi, B, Iafusco, D, Iovane, B, Maffeis, C, Maltoni, G, Olivieri, F, Olivieri, G, Piccini, B, Piccinno, E, Predieri, B, RABBONE, IVANA, Ricciardi, MR, Salzano, G, Schiaffini, R, Tornese, G, Zanfardino, A, Marigliano, M, Troncone, R, Pertile, R, Greco, L, Auricchio, R, Mozzillo, E, null, N, Gallo, F, Grosso, C, Ripoli, C, De Berardinis, F, Coccoli, S, Tiberi, V, Toni, S, Delvecchio, M, Roppolo, R, Lombardo, F, Passanisi, S, Bombaci, B, Casertano, A, Minuto, N, Bassi, M, Maines, E, Savastio, S, Inzaghi, E, Rigamonti, A, Frontino, G, Bruzzi, P & Piona, C 2025, 'Glucometabolic Control and Anti-Transglutaminase Antibodies at Celiac Disease Onset in Type 1 Diabetes Youth', Journal of Clinical Endocrinology and Metabolism, vol. dgaf604. https://doi.org/10.1210/clinem/dgaf604

TY - JOUR

T1 - Glucometabolic Control and Anti-Transglutaminase Antibodies at Celiac Disease Onset in Type 1 Diabetes Youth

AU - Di Candia, Francesca

AU - Rosanio, Francesco Maria

AU - Franceschi, Roberto

AU - Fierro, Alessandro

AU - Bonfanti, Riccardo

AU - Cardella, Francesca

AU - Cherubini, Valentino

AU - D'Annunzio, Giuseppe

AU - Felappi, Barbara

AU - Iafusco, Dario

AU - Iovane, Brunella

AU - Maffeis, Claudio

AU - Maltoni, Giulio

AU - Olivieri, Francesca

AU - Olivieri, Gabriele

AU - Piccini, Barbara

AU - Piccinno, Elvira

AU - Predieri, Barbara

AU - RABBONE, IVANA

AU - Ricciardi, Maria Rossella

AU - Salzano, Giuseppina

AU - Schiaffini, Riccardo

AU - Tornese, Gianluca

AU - Zanfardino, Angela

AU - Marigliano, Marco

AU - Troncone, Riccardo

AU - Pertile, Riccardo

AU - Greco, Luigi

AU - Auricchio, Renata

AU - Mozzillo, Enza

AU - null, null

AU - Gallo, Francesco

AU - Grosso, Caterina

AU - Ripoli, Carlo

AU - De Berardinis, Fiorella

AU - Coccoli, Susanna

AU - Tiberi, Valentina

AU - Toni, Sonia

AU - Delvecchio, Maurizio

AU - Roppolo, Rosanna

AU - Lombardo, Fortunato

AU - Passanisi, Stefano

AU - Bombaci, Bruno

AU - Casertano, Alberto

AU - Minuto, Nicola

AU - Bassi, Marta

AU - Maines, Evelina

AU - Savastio, Silvia

AU - Inzaghi, Elena

AU - Rigamonti, Andrea

AU - Frontino, Giulio

AU - Bruzzi, Patrizia

AU - Piona, Claudia

PY - 2025

Y1 - 2025

N2 - Context Anti-transglutaminase antibodies (anti-TTG IgA) titer is associated with mucosal damage in celiac disease (CD). Objective The primary focus was to correlate anti-TTG IgA titer, HbA1c when CD occurs (HbA1cCD), and Marsh grade in children and adolescents with type 1 diabetes (T1D) at the time of CD diagnosis. As secondary outcomes, we assessed the optimal anti-TTG IgA upper limit of normal (ULN) cutoff for sparing biopsy, and personal and familial autoimmunity history in the individuals with T1D and CD (T1D-CD) compared with T1D-only. Methods In this retrospective observational study, among 6933 individuals with T1D onset (2010-2019), 556 were grouped according to CD onset: before (CD_FIRST), concomitant (CD_CONCOMITANT), or after T1D (T1D_FIRST), and compared with 141 T1D without CD. Measures included HbA1cCD, fold-anti-TTG IgA, anti-TTG IgA cutoff, and autoimmunity history of both groups, as well as Marsh grade in T1D-CD. Results In youths with T1D, HbA1cCD was associated with increased fold-anti-TTG IgA (Spearman r = 0.14, P = .0047). The optimal anti-TTG IgA cutoff for sparing biopsy was 11 ULN. Autoimmunity was prevalent in T1D-CD individuals, who showed more comorbidities than controls (chi(2) 25.4, P < .001), particularly the CD_FIRST (P < .001). Conclusion In children with T1D-CD, worse glucometabolic control is associated with an increase in fold anti-TTG IgA and with worse Marsh grade. A slightly higher anti-TTG IgA cutoff may be neAcessary for sparing biopsy compared to children in the general population. Higher prevalence of autoimmune comorbidities in CD_FIRST suggests that screening for T1D in the CD population should be mandatory.

AB - Context Anti-transglutaminase antibodies (anti-TTG IgA) titer is associated with mucosal damage in celiac disease (CD). Objective The primary focus was to correlate anti-TTG IgA titer, HbA1c when CD occurs (HbA1cCD), and Marsh grade in children and adolescents with type 1 diabetes (T1D) at the time of CD diagnosis. As secondary outcomes, we assessed the optimal anti-TTG IgA upper limit of normal (ULN) cutoff for sparing biopsy, and personal and familial autoimmunity history in the individuals with T1D and CD (T1D-CD) compared with T1D-only. Methods In this retrospective observational study, among 6933 individuals with T1D onset (2010-2019), 556 were grouped according to CD onset: before (CD_FIRST), concomitant (CD_CONCOMITANT), or after T1D (T1D_FIRST), and compared with 141 T1D without CD. Measures included HbA1cCD, fold-anti-TTG IgA, anti-TTG IgA cutoff, and autoimmunity history of both groups, as well as Marsh grade in T1D-CD. Results In youths with T1D, HbA1cCD was associated with increased fold-anti-TTG IgA (Spearman r = 0.14, P = .0047). The optimal anti-TTG IgA cutoff for sparing biopsy was 11 ULN. Autoimmunity was prevalent in T1D-CD individuals, who showed more comorbidities than controls (chi(2) 25.4, P < .001), particularly the CD_FIRST (P < .001). Conclusion In children with T1D-CD, worse glucometabolic control is associated with an increase in fold anti-TTG IgA and with worse Marsh grade. A slightly higher anti-TTG IgA cutoff may be neAcessary for sparing biopsy compared to children in the general population. Higher prevalence of autoimmune comorbidities in CD_FIRST suggests that screening for T1D in the CD population should be mandatory.

KW - Anti-tissue Transglutaminase

KW - Autoimmunity

KW - Celiac Disease

KW - Gluten-Free Diet

KW - Glycosylated haemoglobin

KW - Type 1 Diabetes

KW - Anti-tissue Transglutaminase

KW - Autoimmunity

KW - Celiac Disease

KW - Gluten-Free Diet

KW - Glycosylated haemoglobin

KW - Type 1 Diabetes

UR - https://iris.uniupo.it/handle/11579/223523

U2 - 10.1210/clinem/dgaf604

DO - 10.1210/clinem/dgaf604

M3 - Article

SN - 0021-972X

VL - dgaf604

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

ER -

Glucometabolic Control and Anti-Transglutaminase Antibodies at Celiac Disease Onset in Type 1 Diabetes Youth

Abstract

Keywords

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