Genomic aberrations affecting the outcome of immunodeficiency-related diffuse large B-cell lymphoma

Ivo Kwee; Daniela Capello; Andrea Rinaldi; Paola M.V. Rancoita; Govind Bhagat; Tim C. Greiner; Michele Spina; Annunziata Gloghini; Wing C. Chan; Marco Paulli; Emanuele Zucca; Umberto Tirelli; Antonino Carbone; Gianluca Gaidano; Francesco Bertoni

doi:10.3109/10428194.2011.607729

Genomic aberrations affecting the outcome of immunodeficiency-related diffuse large B-cell lymphoma

Ivo Kwee, Daniela Capello, Andrea Rinaldi, Paola M.V. Rancoita, Govind Bhagat, Tim C. Greiner, Michele Spina, Annunziata Gloghini, Wing C. Chan, Marco Paulli, Emanuele Zucca, Umberto Tirelli, Antonino Carbone, Gianluca Gaidano, Francesco Bertoni

Dipartimento di Medicina Traslazionale

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

The objective of this study was to evaluate the prognostic impact of genomic regions in a series of human immunodeficiency virus (HIV)-related diffuse large B-cell lymphomas (HIV-DLBCLs) and post-transplant DLBCLs (PT-DLBCLs) analyzed by genome-wide DNA profiling. Minimal common regions (MCRs) were estimated on genomic profiles obtained using Affymetrix Human Mapping 250k Nsp I arrays and tested for their impact on clinical outcome by univariate analysis on 36 PT-DLBCLs, 19 HIV-DLBCLs and, as a control group, 149 DLBCLs arising in immunocompetent individuals (IC-DLBCLs). PT-DLBCL and HIV-DLBCL presented a similar outcome. Immunodeficiency-related DLBCL (ID-DLBCL) had a worse overall survival (OS) than IC-DLBCL. Seven MCRs showed a statistical impact on OS in PT-DLBCL and four in HIV-DLBCL. Among these, the presence of gains at 1q or at 18q defined a group of patients with PT-DLBCL with a very poor outcome (p < 0.0001). The presence of del(3p14.2) or of + 2p23.1 identified a group of HIV-DLBCLs with a very poor outcome (p = 0.0072). It was concluded that genomic aberrations affecting outcome differ between ID-DLBCL and IC-DLBCL and are also dependent on the type of acquired immunodeficiency.

Lingua originale	Inglese
pagine (da-a)	71-76
Numero di pagine	6
Rivista	Leukemia and Lymphoma
Volume	53
Numero di pubblicazione	1
DOI	https://doi.org/10.3109/10428194.2011.607729
Stato di pubblicazione	Pubblicato - gen 2012

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Kwee, I., Capello, D., Rinaldi, A., Rancoita, P. M. V., Bhagat, G., Greiner, T. C., Spina, M., Gloghini, A., Chan, W. C., Paulli, M., Zucca, E., Tirelli, U., Carbone, A., Gaidano, G., & Bertoni, F. (2012). Genomic aberrations affecting the outcome of immunodeficiency-related diffuse large B-cell lymphoma. Leukemia and Lymphoma, 53(1), 71-76. https://doi.org/10.3109/10428194.2011.607729

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title = "Genomic aberrations affecting the outcome of immunodeficiency-related diffuse large B-cell lymphoma",

abstract = "The objective of this study was to evaluate the prognostic impact of genomic regions in a series of human immunodeficiency virus (HIV)-related diffuse large B-cell lymphomas (HIV-DLBCLs) and post-transplant DLBCLs (PT-DLBCLs) analyzed by genome-wide DNA profiling. Minimal common regions (MCRs) were estimated on genomic profiles obtained using Affymetrix Human Mapping 250k Nsp I arrays and tested for their impact on clinical outcome by univariate analysis on 36 PT-DLBCLs, 19 HIV-DLBCLs and, as a control group, 149 DLBCLs arising in immunocompetent individuals (IC-DLBCLs). PT-DLBCL and HIV-DLBCL presented a similar outcome. Immunodeficiency-related DLBCL (ID-DLBCL) had a worse overall survival (OS) than IC-DLBCL. Seven MCRs showed a statistical impact on OS in PT-DLBCL and four in HIV-DLBCL. Among these, the presence of gains at 1q or at 18q defined a group of patients with PT-DLBCL with a very poor outcome (p < 0.0001). The presence of del(3p14.2) or of + 2p23.1 identified a group of HIV-DLBCLs with a very poor outcome (p = 0.0072). It was concluded that genomic aberrations affecting outcome differ between ID-DLBCL and IC-DLBCL and are also dependent on the type of acquired immunodeficiency.",

keywords = "Diffuse large B-cell lymphoma, FHIT, HIV, Immunodeficiency, Lymphoma, Organ transplant, Outcome",

author = "Ivo Kwee and Daniela Capello and Andrea Rinaldi and Rancoita, {Paola M.V.} and Govind Bhagat and Greiner, {Tim C.} and Michele Spina and Annunziata Gloghini and Chan, {Wing C.} and Marco Paulli and Emanuele Zucca and Umberto Tirelli and Antonino Carbone and Gianluca Gaidano and Francesco Bertoni",

note = "Funding Information: This work was supported by: Oncosuisse grant OCS-1939-8-2006; Swiss National Science Foundation (grants 205321-112430, 205320-121886/1); Cantone Ticino ( Computational life science/Ticino in rete” program); Fondazione per la ca e la Cura sui Linfomi (Lugano, Switzerland); Ricerca Sanitaria Finalizzata 2008 and 2009, Regione Piemonte, Torino, Italy; VI Programma Nazionale di Ricerca sull{\textquoteright}AIDS, ISS, Rome, Italy; Novara-AIL Onlus; PHS grant, UO1 CA 114778.",

year = "2012",

month = jan,

doi = "10.3109/10428194.2011.607729",

language = "English",

volume = "53",

pages = "71--76",

journal = "Leukemia and Lymphoma",

issn = "1042-8194",

publisher = "Informa Healthcare",

number = "1",

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Kwee, I, Capello, D, Rinaldi, A, Rancoita, PMV, Bhagat, G, Greiner, TC, Spina, M, Gloghini, A, Chan, WC, Paulli, M, Zucca, E, Tirelli, U, Carbone, A, Gaidano, G & Bertoni, F 2012, 'Genomic aberrations affecting the outcome of immunodeficiency-related diffuse large B-cell lymphoma', Leukemia and Lymphoma, vol. 53, n. 1, pagg. 71-76. https://doi.org/10.3109/10428194.2011.607729

TY - JOUR

T1 - Genomic aberrations affecting the outcome of immunodeficiency-related diffuse large B-cell lymphoma

AU - Kwee, Ivo

AU - Capello, Daniela

AU - Rinaldi, Andrea

AU - Rancoita, Paola M.V.

AU - Bhagat, Govind

AU - Greiner, Tim C.

AU - Spina, Michele

AU - Gloghini, Annunziata

AU - Chan, Wing C.

AU - Paulli, Marco

AU - Zucca, Emanuele

AU - Tirelli, Umberto

AU - Carbone, Antonino

AU - Gaidano, Gianluca

AU - Bertoni, Francesco

N1 - Funding Information: This work was supported by: Oncosuisse grant OCS-1939-8-2006; Swiss National Science Foundation (grants 205321-112430, 205320-121886/1); Cantone Ticino ( Computational life science/Ticino in rete” program); Fondazione per la ca e la Cura sui Linfomi (Lugano, Switzerland); Ricerca Sanitaria Finalizzata 2008 and 2009, Regione Piemonte, Torino, Italy; VI Programma Nazionale di Ricerca sull’AIDS, ISS, Rome, Italy; Novara-AIL Onlus; PHS grant, UO1 CA 114778.

PY - 2012/1

Y1 - 2012/1

N2 - The objective of this study was to evaluate the prognostic impact of genomic regions in a series of human immunodeficiency virus (HIV)-related diffuse large B-cell lymphomas (HIV-DLBCLs) and post-transplant DLBCLs (PT-DLBCLs) analyzed by genome-wide DNA profiling. Minimal common regions (MCRs) were estimated on genomic profiles obtained using Affymetrix Human Mapping 250k Nsp I arrays and tested for their impact on clinical outcome by univariate analysis on 36 PT-DLBCLs, 19 HIV-DLBCLs and, as a control group, 149 DLBCLs arising in immunocompetent individuals (IC-DLBCLs). PT-DLBCL and HIV-DLBCL presented a similar outcome. Immunodeficiency-related DLBCL (ID-DLBCL) had a worse overall survival (OS) than IC-DLBCL. Seven MCRs showed a statistical impact on OS in PT-DLBCL and four in HIV-DLBCL. Among these, the presence of gains at 1q or at 18q defined a group of patients with PT-DLBCL with a very poor outcome (p < 0.0001). The presence of del(3p14.2) or of + 2p23.1 identified a group of HIV-DLBCLs with a very poor outcome (p = 0.0072). It was concluded that genomic aberrations affecting outcome differ between ID-DLBCL and IC-DLBCL and are also dependent on the type of acquired immunodeficiency.

AB - The objective of this study was to evaluate the prognostic impact of genomic regions in a series of human immunodeficiency virus (HIV)-related diffuse large B-cell lymphomas (HIV-DLBCLs) and post-transplant DLBCLs (PT-DLBCLs) analyzed by genome-wide DNA profiling. Minimal common regions (MCRs) were estimated on genomic profiles obtained using Affymetrix Human Mapping 250k Nsp I arrays and tested for their impact on clinical outcome by univariate analysis on 36 PT-DLBCLs, 19 HIV-DLBCLs and, as a control group, 149 DLBCLs arising in immunocompetent individuals (IC-DLBCLs). PT-DLBCL and HIV-DLBCL presented a similar outcome. Immunodeficiency-related DLBCL (ID-DLBCL) had a worse overall survival (OS) than IC-DLBCL. Seven MCRs showed a statistical impact on OS in PT-DLBCL and four in HIV-DLBCL. Among these, the presence of gains at 1q or at 18q defined a group of patients with PT-DLBCL with a very poor outcome (p < 0.0001). The presence of del(3p14.2) or of + 2p23.1 identified a group of HIV-DLBCLs with a very poor outcome (p = 0.0072). It was concluded that genomic aberrations affecting outcome differ between ID-DLBCL and IC-DLBCL and are also dependent on the type of acquired immunodeficiency.

KW - Diffuse large B-cell lymphoma

KW - FHIT

KW - HIV

KW - Immunodeficiency

KW - Lymphoma

KW - Organ transplant

KW - Outcome

UR - http://www.scopus.com/inward/record.url?scp=84855443355&partnerID=8YFLogxK

U2 - 10.3109/10428194.2011.607729

DO - 10.3109/10428194.2011.607729

M3 - Article

SN - 1042-8194

VL - 53

SP - 71

EP - 76

JO - Leukemia and Lymphoma

JF - Leukemia and Lymphoma

IS - 1

ER -

Genomic aberrations affecting the outcome of immunodeficiency-related diffuse large B-cell lymphoma

Abstract

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