TY - JOUR
T1 - Genome-wide DNA profiling of marginal zone lymphomas identifies subtype-specific lesions with an impact on the clinical outcome
AU - Rinaldi, Andrea
AU - Mian, Michael
AU - Chigrinova, Ekaterina
AU - Arcaini, Luca
AU - Bhagat, Govind
AU - Novak, Urban
AU - Rancoita, Paola M.V.
AU - De Campos, Cassio P.
AU - Forconi, Francesco
AU - Gascoyne, Randy D.
AU - Facchetti, Fabio
AU - Ponzoni, Maurilio
AU - Govi, Silvia
AU - Ferreri, Andrés J.M.
AU - Mollejo, Manuela
AU - Piris, Miguel A.
AU - Baldini, Luca
AU - Soulier, Jean
AU - Thieblemont, Catherine
AU - Canzonieri, Vincenzo
AU - Gattei, Valter
AU - Marasca, Roberto
AU - Franceschetti, Silvia
AU - Gaidano, Gianluca
AU - Tucci, Alessandra
AU - Uccella, Silvia
AU - Tibiletti, Maria Grazia
AU - Dirnhofer, Stephan
AU - Tripodo, Claudio
AU - Doglioni, Claudio
AU - Favera, Riccardo Dalla
AU - Cavalli, Franco
AU - Zucca, Emanuele
AU - Kwee, Ivo
AU - Bertoni, Francesco
PY - 2011/2/3
Y1 - 2011/2/3
N2 - Marginal zone B-cell lymphomas (MZLs) have been divided into 3 distinct subtypes (extranodal MZLs of mucosa-associated lymphoid tissue [MALT] type, nodal MZLs, and splenic MZLs). Nevertheless, the relationship between the subtypes is still unclear. We performed a comprehensive analysis of genomic DNA copy number changes in a very large series of MZL cases with the aim of addressing this question. Samples from 218 MZL patients (25 nodal, 57 MALT, 134 splenic, and 2 not better specified MZLs) were analyzed with the Affymetrix Human Mapping 250K SNP arrays, and the data combined with matched gene expression in 33 of 218 cases. MALT lymphoma presented significantly more frequently gains at 3p, 6p, 18p, and del(6q23) (TNFAIP3/A20), whereas splenic MZLs was associated with del(7q31), del(8p). Nodal MZLs did not show statistically significant differences compared with MALT lymphoma while lacking the splenic MZLs-related 7q losses. Gains of 3q and 18q were common to all 3 subtypes. del(8p) was often present together with del(17p) (TP53). Although del(17p) did not determine a worse outcome and del(8p) was only of borderline significance, the presence of both deletions had a highly significant negative impact on the outcome of splenic MZLs.
AB - Marginal zone B-cell lymphomas (MZLs) have been divided into 3 distinct subtypes (extranodal MZLs of mucosa-associated lymphoid tissue [MALT] type, nodal MZLs, and splenic MZLs). Nevertheless, the relationship between the subtypes is still unclear. We performed a comprehensive analysis of genomic DNA copy number changes in a very large series of MZL cases with the aim of addressing this question. Samples from 218 MZL patients (25 nodal, 57 MALT, 134 splenic, and 2 not better specified MZLs) were analyzed with the Affymetrix Human Mapping 250K SNP arrays, and the data combined with matched gene expression in 33 of 218 cases. MALT lymphoma presented significantly more frequently gains at 3p, 6p, 18p, and del(6q23) (TNFAIP3/A20), whereas splenic MZLs was associated with del(7q31), del(8p). Nodal MZLs did not show statistically significant differences compared with MALT lymphoma while lacking the splenic MZLs-related 7q losses. Gains of 3q and 18q were common to all 3 subtypes. del(8p) was often present together with del(17p) (TP53). Although del(17p) did not determine a worse outcome and del(8p) was only of borderline significance, the presence of both deletions had a highly significant negative impact on the outcome of splenic MZLs.
UR - https://www.scopus.com/pages/publications/79551650559
U2 - 10.1182/blood-2010-01-264275
DO - 10.1182/blood-2010-01-264275
M3 - Article
SN - 0006-4971
VL - 117
SP - 1595
EP - 1604
JO - Blood
JF - Blood
IS - 5
ER -