Genome-wide association study of endometrial cancer in E2C2

Immaculata De Vivo; Jennifer Prescott; Veronica Wendy Setiawan; Sara H. Olson; Nicolas Wentzensen; John Attia; Amanda Black; Louise Brinton; Chu Chen; Constance Chen; Linda S. Cook; Marta Crous-Bou; Jennifer Doherty; Alison M. Dunning; Douglas F. Easton; Christine M. Friedenreich; Montserrat Garcia-Closas; Mia M. Gaudet; Christopher Haiman; Susan E. Hankinson; Patricia Hartge; Brian E. Henderson; Elizabeth Holliday; Pamela L. Horn-Ross; David J. Hunter; Loic Le Marchand; Xiaolin Liang; Jolanta Lissowska; Jirong Long; Lingeng Lu; Anthony M. Magliocco; Mark McEvoy; Tracy A. O'Mara; Irene Orlow; Jodie N. Painter; Loreall Pooler; Radhai Rastogi; Timothy R. Rebbeck; Harvey Risch; Carlotta Sacerdote; Fredrick Schumacher; Rodney J. Scott; Xin Sheng; Xiao Ou Shu; Amanda B. Spurdle; Deborah Thompson; David Vanden Berg; Noel S. Weiss; Lucy Xia; Yong Bing Xiang; Hannah P. Yang; Herbert Yu; Wei Zheng; Stephen Chanock; Peter Kraft

doi:10.1007/s00439-013-1369-1

Genome-wide association study of endometrial cancer in E2C2

Immaculata De Vivo, Jennifer Prescott, Veronica Wendy Setiawan, Sara H. Olson, Nicolas Wentzensen, John Attia, Amanda Black, Louise Brinton, Chu Chen, Constance Chen, Linda S. Cook, Marta Crous-Bou, Jennifer Doherty, Alison M. Dunning, Douglas F. Easton, Christine M. Friedenreich, Montserrat Garcia-Closas, Mia M. Gaudet, Christopher Haiman, Susan E. HankinsonPatricia Hartge, Brian E. Henderson, Elizabeth Holliday, Pamela L. Horn-Ross, David J. Hunter, Loic Le Marchand, Xiaolin Liang, Jolanta Lissowska, Jirong Long, Lingeng Lu, Anthony M. Magliocco, Mark McEvoy, Tracy A. O'Mara, Irene Orlow, Jodie N. Painter, Loreall Pooler, Radhai Rastogi, Timothy R. Rebbeck, Harvey Risch, Carlotta Sacerdote, Fredrick Schumacher, Rodney J. Scott, Xin Sheng, Xiao Ou Shu, Amanda B. Spurdle, Deborah Thompson, David Vanden Berg, Noel S. Weiss, Lucy Xia, Yong Bing Xiang, Hannah P. Yang, Herbert Yu, Wei Zheng, Stephen Chanock, Peter Kraft

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Endometrial cancer (EC), a neoplasm of the uterine epithelial lining, is the most common gynecological malignancy in developed countries and the fourth most common cancer among US women. Women with a family history of EC have an increased risk for the disease, suggesting that inherited genetic factors play a role. We conducted a two-stage genome-wide association study of Type I EC. Stage 1 included 5,472 women (2,695 cases and 2,777 controls) of European ancestry from seven studies. We selected independent single-nucleotide polymorphisms (SNPs) that displayed the most significant associations with EC in Stage 1 for replication among 17,948 women (4,382 cases and 13,566 controls) in a multiethnic population (African America, Asian, Latina, Hawaiian and European ancestry), from nine studies. Although no novel variants reached genome-wide significance, we replicated previously identified associations with genetic markers near the HNF1B locus. Our findings suggest that larger studies with specific tumor classification are necessary to identify novel genetic polymorphisms associated with EC susceptibility.

Lingua originale	Inglese
pagine (da-a)	211-224
Numero di pagine	14
Rivista	Human Genetics
Volume	133
Numero di pubblicazione	2
DOI	https://doi.org/10.1007/s00439-013-1369-1
Stato di pubblicazione	Pubblicato - feb 2014
Pubblicato esternamente	Sì

OSS delle Nazioni Unite

Questo processo contribuisce al raggiungimento dei seguenti obiettivi di sviluppo sostenibile

Accesso al documento

10.1007/s00439-013-1369-1

Altri file e collegamenti

Link to publication in Scopus

Cita questo

De Vivo, I., Prescott, J., Setiawan, V. W., Olson, S. H., Wentzensen, N., Attia, J., Black, A., Brinton, L., Chen, C., Chen, C., Cook, L. S., Crous-Bou, M., Doherty, J., Dunning, A. M., Easton, D. F., Friedenreich, C. M., Garcia-Closas, M., Gaudet, M. M., Haiman, C., ... Kraft, P. (2014). Genome-wide association study of endometrial cancer in E2C2. Human Genetics, 133(2), 211-224. https://doi.org/10.1007/s00439-013-1369-1

@article{85f8a1711e344e10b07c4df87b4d610c,

title = "Genome-wide association study of endometrial cancer in E2C2",

abstract = "Endometrial cancer (EC), a neoplasm of the uterine epithelial lining, is the most common gynecological malignancy in developed countries and the fourth most common cancer among US women. Women with a family history of EC have an increased risk for the disease, suggesting that inherited genetic factors play a role. We conducted a two-stage genome-wide association study of Type I EC. Stage 1 included 5,472 women (2,695 cases and 2,777 controls) of European ancestry from seven studies. We selected independent single-nucleotide polymorphisms (SNPs) that displayed the most significant associations with EC in Stage 1 for replication among 17,948 women (4,382 cases and 13,566 controls) in a multiethnic population (African America, Asian, Latina, Hawaiian and European ancestry), from nine studies. Although no novel variants reached genome-wide significance, we replicated previously identified associations with genetic markers near the HNF1B locus. Our findings suggest that larger studies with specific tumor classification are necessary to identify novel genetic polymorphisms associated with EC susceptibility.",

author = "\{De Vivo\}, Immaculata and Jennifer Prescott and Setiawan, \{Veronica Wendy\} and Olson, \{Sara H.\} and Nicolas Wentzensen and John Attia and Amanda Black and Louise Brinton and Chu Chen and Constance Chen and Cook, \{Linda S.\} and Marta Crous-Bou and Jennifer Doherty and Dunning, \{Alison M.\} and Easton, \{Douglas F.\} and Friedenreich, \{Christine M.\} and Montserrat Garcia-Closas and Gaudet, \{Mia M.\} and Christopher Haiman and Hankinson, \{Susan E.\} and Patricia Hartge and Henderson, \{Brian E.\} and Elizabeth Holliday and Horn-Ross, \{Pamela L.\} and Hunter, \{David J.\} and \{Le Marchand\}, Loic and Xiaolin Liang and Jolanta Lissowska and Jirong Long and Lingeng Lu and Magliocco, \{Anthony M.\} and Mark McEvoy and O'Mara, \{Tracy A.\} and Irene Orlow and Painter, \{Jodie N.\} and Loreall Pooler and Radhai Rastogi and Rebbeck, \{Timothy R.\} and Harvey Risch and Carlotta Sacerdote and Fredrick Schumacher and Scott, \{Rodney J.\} and Xin Sheng and Shu, \{Xiao Ou\} and Spurdle, \{Amanda B.\} and Deborah Thompson and \{Vanden Berg\}, David and Weiss, \{Noel S.\} and Lucy Xia and Xiang, \{Yong Bing\} and Yang, \{Hannah P.\} and Herbert Yu and Wei Zheng and Stephen Chanock and Peter Kraft",

year = "2014",

month = feb,

doi = "10.1007/s00439-013-1369-1",

language = "English",

volume = "133",

pages = "211--224",

journal = "Human Genetics",

issn = "0340-6717",

publisher = "Springer Science and Business Media Deutschland GmbH",

number = "2",

}

De Vivo, I, Prescott, J, Setiawan, VW, Olson, SH, Wentzensen, N, Attia, J, Black, A, Brinton, L, Chen, C, Chen, C, Cook, LS, Crous-Bou, M, Doherty, J, Dunning, AM, Easton, DF, Friedenreich, CM, Garcia-Closas, M, Gaudet, MM, Haiman, C, Hankinson, SE, Hartge, P, Henderson, BE, Holliday, E, Horn-Ross, PL, Hunter, DJ, Le Marchand, L, Liang, X, Lissowska, J, Long, J, Lu, L, Magliocco, AM, McEvoy, M, O'Mara, TA, Orlow, I, Painter, JN, Pooler, L, Rastogi, R, Rebbeck, TR, Risch, H, Sacerdote, C, Schumacher, F, Scott, RJ, Sheng, X, Shu, XO, Spurdle, AB, Thompson, D, Vanden Berg, D, Weiss, NS, Xia, L, Xiang, YB, Yang, HP, Yu, H, Zheng, W, Chanock, S & Kraft, P 2014, 'Genome-wide association study of endometrial cancer in E2C2', Human Genetics, vol. 133, n. 2, pagg. 211-224. https://doi.org/10.1007/s00439-013-1369-1

TY - JOUR

T1 - Genome-wide association study of endometrial cancer in E2C2

AU - De Vivo, Immaculata

AU - Prescott, Jennifer

AU - Setiawan, Veronica Wendy

AU - Olson, Sara H.

AU - Wentzensen, Nicolas

AU - Attia, John

AU - Black, Amanda

AU - Brinton, Louise

AU - Chen, Chu

AU - Chen, Constance

AU - Cook, Linda S.

AU - Crous-Bou, Marta

AU - Doherty, Jennifer

AU - Dunning, Alison M.

AU - Easton, Douglas F.

AU - Friedenreich, Christine M.

AU - Garcia-Closas, Montserrat

AU - Gaudet, Mia M.

AU - Haiman, Christopher

AU - Hankinson, Susan E.

AU - Hartge, Patricia

AU - Henderson, Brian E.

AU - Holliday, Elizabeth

AU - Horn-Ross, Pamela L.

AU - Hunter, David J.

AU - Le Marchand, Loic

AU - Liang, Xiaolin

AU - Lissowska, Jolanta

AU - Long, Jirong

AU - Lu, Lingeng

AU - Magliocco, Anthony M.

AU - McEvoy, Mark

AU - O'Mara, Tracy A.

AU - Orlow, Irene

AU - Painter, Jodie N.

AU - Pooler, Loreall

AU - Rastogi, Radhai

AU - Rebbeck, Timothy R.

AU - Risch, Harvey

AU - Sacerdote, Carlotta

AU - Schumacher, Fredrick

AU - Scott, Rodney J.

AU - Sheng, Xin

AU - Shu, Xiao Ou

AU - Spurdle, Amanda B.

AU - Thompson, Deborah

AU - Vanden Berg, David

AU - Weiss, Noel S.

AU - Xia, Lucy

AU - Xiang, Yong Bing

AU - Yang, Hannah P.

AU - Yu, Herbert

AU - Zheng, Wei

AU - Chanock, Stephen

AU - Kraft, Peter

PY - 2014/2

Y1 - 2014/2

N2 - Endometrial cancer (EC), a neoplasm of the uterine epithelial lining, is the most common gynecological malignancy in developed countries and the fourth most common cancer among US women. Women with a family history of EC have an increased risk for the disease, suggesting that inherited genetic factors play a role. We conducted a two-stage genome-wide association study of Type I EC. Stage 1 included 5,472 women (2,695 cases and 2,777 controls) of European ancestry from seven studies. We selected independent single-nucleotide polymorphisms (SNPs) that displayed the most significant associations with EC in Stage 1 for replication among 17,948 women (4,382 cases and 13,566 controls) in a multiethnic population (African America, Asian, Latina, Hawaiian and European ancestry), from nine studies. Although no novel variants reached genome-wide significance, we replicated previously identified associations with genetic markers near the HNF1B locus. Our findings suggest that larger studies with specific tumor classification are necessary to identify novel genetic polymorphisms associated with EC susceptibility.

AB - Endometrial cancer (EC), a neoplasm of the uterine epithelial lining, is the most common gynecological malignancy in developed countries and the fourth most common cancer among US women. Women with a family history of EC have an increased risk for the disease, suggesting that inherited genetic factors play a role. We conducted a two-stage genome-wide association study of Type I EC. Stage 1 included 5,472 women (2,695 cases and 2,777 controls) of European ancestry from seven studies. We selected independent single-nucleotide polymorphisms (SNPs) that displayed the most significant associations with EC in Stage 1 for replication among 17,948 women (4,382 cases and 13,566 controls) in a multiethnic population (African America, Asian, Latina, Hawaiian and European ancestry), from nine studies. Although no novel variants reached genome-wide significance, we replicated previously identified associations with genetic markers near the HNF1B locus. Our findings suggest that larger studies with specific tumor classification are necessary to identify novel genetic polymorphisms associated with EC susceptibility.

UR - http://www.scopus.com/inward/record.url?scp=84893207757&partnerID=8YFLogxK

U2 - 10.1007/s00439-013-1369-1

DO - 10.1007/s00439-013-1369-1

M3 - Article

SN - 0340-6717

VL - 133

SP - 211

EP - 224

JO - Human Genetics

JF - Human Genetics

IS - 2

ER -

Genome-wide association study of endometrial cancer in E2C2

Abstract

OSS delle Nazioni Unite

Accesso al documento

Altri file e collegamenti

Fingerprint

Cita questo