Genetic variation in genes of the fatty acid synthesis pathway and breast cancer risk

Daniele Campa; James McKay; Olga Sinilnikova; Anika Hüsing; Ulla Vogel; Rikke Dalgaard Hansen; Kim Overvad; Petra Mariann Witt; Françoise Clavel-Chapelon; Marie Christine Boutron-Ruault; Veronique Chajes; Sabine Rohrmann; Jenny Chang-Claude; Heiner Boeing; Eva Fisher; Antonia Trichopoulou; Dimitrios Trichopoulos; Domenico Palli; Anna Villarini; Carlotta Sacerdote; Amalia Mattiello; Rosario Tumino; Petra H.M. Peeters; Carla H. Van Gils; H. Bas Bueno-De-Mesquita; Eiliv Lund; María Dolores Chirlaque; Núria Sala; Laudina Rodriguez Suarez; Aurelio Barricarte; Miren Dorronsoro; Maria José Sánchez; Per Lenner; Göran Hallmans; Kostas Tsilidis; Sheila Bingham; Kay Tee Khaw; Valentina Gallo; Teresa Norat; Elio Riboli; Sabina Rinaldi; Gilbert Lenoir; Sean V. Tavtigian; Federico Canzian; Rudolf Kaaks

doi:10.1007/s10549-009-0347-8

Genetic variation in genes of the fatty acid synthesis pathway and breast cancer risk

Daniele Campa, James McKay, Olga Sinilnikova, Anika Hüsing, Ulla Vogel, Rikke Dalgaard Hansen, Kim Overvad, Petra Mariann Witt, Françoise Clavel-Chapelon, Marie Christine Boutron-Ruault, Veronique Chajes, Sabine Rohrmann, Jenny Chang-Claude, Heiner Boeing, Eva Fisher, Antonia Trichopoulou, Dimitrios Trichopoulos, Domenico Palli, Anna Villarini, Carlotta SacerdoteAmalia Mattiello, Rosario Tumino, Petra H.M. Peeters, Carla H. Van Gils, H. Bas Bueno-De-Mesquita, Eiliv Lund, María Dolores Chirlaque, Núria Sala, Laudina Rodriguez Suarez, Aurelio Barricarte, Miren Dorronsoro, Maria José Sánchez, Per Lenner, Göran Hallmans, Kostas Tsilidis, Sheila Bingham, Kay Tee Khaw, Valentina Gallo, Teresa Norat, Elio Riboli, Sabina Rinaldi, Gilbert Lenoir, Sean V. Tavtigian, Federico Canzian, Rudolf Kaaks

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Fatty acid synthase (FAS) is the major enzyme of lipogenesis. It catalyzes the NADPH-dependent condensation of acetyl-CoA and malonyl-CoA to produce palmitic acid. Transcription of the FAS gene is controlled synergistically by the transcription factors ChREBP (carbohydrate response element-binding protein), which is induced by glucose, and SREBP-1 (sterol response element-binding protein-1), which is stimulated by insulin through the PI3K/Akt signal transduction pathway. We investigated whether the genetic variability of the genes encoding for ChREBP, SREBP and FAS (respectively, MLXIPL, SREBF1 and FASN) is related to breast cancer risk and body-mass index (BMI) by studying 1,294 breast cancer cases and 2,452 controls from the European Prospective Investigation on Cancer (EPIC). We resequenced the FAS gene and combined information of SNPs found by resequencing and SNPs from public databases. Using a tagging approach and selecting 20 SNPs, we covered all the common genetic variation of these genes. In this study we were not able to find any statistically significant association between the SNPs in the FAS, ChREBP and SREPB-1 genes and an increased risk of breast cancer overall and by subgroups of age, menopausal status, hormone replacement therapy (HRT) use or BMI. On the other hand, we found that two SNPs in FASN were associated with BMI.

Lingua originale	Inglese
pagine (da-a)	565-574
Numero di pagine	10
Rivista	Breast Cancer Research and Treatment
Volume	118
Numero di pubblicazione	3
DOI	https://doi.org/10.1007/s10549-009-0347-8
Stato di pubblicazione	Pubblicato - dic 2009
Pubblicato esternamente	Sì

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10.1007/s10549-009-0347-8

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Campa, D., McKay, J., Sinilnikova, O., Hüsing, A., Vogel, U., Hansen, R. D., Overvad, K., Witt, P. M., Clavel-Chapelon, F., Boutron-Ruault, M. C., Chajes, V., Rohrmann, S., Chang-Claude, J., Boeing, H., Fisher, E., Trichopoulou, A., Trichopoulos, D., Palli, D., Villarini, A., ... Kaaks, R. (2009). Genetic variation in genes of the fatty acid synthesis pathway and breast cancer risk. Breast Cancer Research and Treatment, 118(3), 565-574. https://doi.org/10.1007/s10549-009-0347-8

@article{f98e2c2f24a1435fae06d1c897d2f343,

title = "Genetic variation in genes of the fatty acid synthesis pathway and breast cancer risk",

abstract = "Fatty acid synthase (FAS) is the major enzyme of lipogenesis. It catalyzes the NADPH-dependent condensation of acetyl-CoA and malonyl-CoA to produce palmitic acid. Transcription of the FAS gene is controlled synergistically by the transcription factors ChREBP (carbohydrate response element-binding protein), which is induced by glucose, and SREBP-1 (sterol response element-binding protein-1), which is stimulated by insulin through the PI3K/Akt signal transduction pathway. We investigated whether the genetic variability of the genes encoding for ChREBP, SREBP and FAS (respectively, MLXIPL, SREBF1 and FASN) is related to breast cancer risk and body-mass index (BMI) by studying 1,294 breast cancer cases and 2,452 controls from the European Prospective Investigation on Cancer (EPIC). We resequenced the FAS gene and combined information of SNPs found by resequencing and SNPs from public databases. Using a tagging approach and selecting 20 SNPs, we covered all the common genetic variation of these genes. In this study we were not able to find any statistically significant association between the SNPs in the FAS, ChREBP and SREPB-1 genes and an increased risk of breast cancer overall and by subgroups of age, menopausal status, hormone replacement therapy (HRT) use or BMI. On the other hand, we found that two SNPs in FASN were associated with BMI.",

keywords = "Body-mass index, Breast cancer, Carbohydrate response element-binding protein, Fatty acid synthase, Sterol response element-binding protein-1, Susceptibility to cancer",

author = "Daniele Campa and James McKay and Olga Sinilnikova and Anika H{\"u}sing and Ulla Vogel and Hansen, {Rikke Dalgaard} and Kim Overvad and Witt, {Petra Mariann} and Fran{\c c}oise Clavel-Chapelon and Boutron-Ruault, {Marie Christine} and Veronique Chajes and Sabine Rohrmann and Jenny Chang-Claude and Heiner Boeing and Eva Fisher and Antonia Trichopoulou and Dimitrios Trichopoulos and Domenico Palli and Anna Villarini and Carlotta Sacerdote and Amalia Mattiello and Rosario Tumino and Peeters, {Petra H.M.} and {Van Gils}, {Carla H.} and {Bas Bueno-De-Mesquita}, H. and Eiliv Lund and Chirlaque, {Mar{\'i}a Dolores} and N{\'u}ria Sala and Suarez, {Laudina Rodriguez} and Aurelio Barricarte and Miren Dorronsoro and S{\'a}nchez, {Maria Jos{\'e}} and Per Lenner and G{\"o}ran Hallmans and Kostas Tsilidis and Sheila Bingham and Khaw, {Kay Tee} and Valentina Gallo and Teresa Norat and Elio Riboli and Sabina Rinaldi and Gilbert Lenoir and Tavtigian, {Sean V.} and Federico Canzian and Rudolf Kaaks",

year = "2009",

month = dec,

doi = "10.1007/s10549-009-0347-8",

language = "English",

volume = "118",

pages = "565--574",

journal = "Breast Cancer Research and Treatment",

issn = "0167-6806",

publisher = "Springer",

number = "3",

}

Campa, D, McKay, J, Sinilnikova, O, Hüsing, A, Vogel, U, Hansen, RD, Overvad, K, Witt, PM, Clavel-Chapelon, F, Boutron-Ruault, MC, Chajes, V, Rohrmann, S, Chang-Claude, J, Boeing, H, Fisher, E, Trichopoulou, A, Trichopoulos, D, Palli, D, Villarini, A, Sacerdote, C, Mattiello, A, Tumino, R, Peeters, PHM, Van Gils, CH, Bas Bueno-De-Mesquita, H, Lund, E, Chirlaque, MD, Sala, N, Suarez, LR, Barricarte, A, Dorronsoro, M, Sánchez, MJ, Lenner, P, Hallmans, G, Tsilidis, K, Bingham, S, Khaw, KT, Gallo, V, Norat, T, Riboli, E, Rinaldi, S, Lenoir, G, Tavtigian, SV, Canzian, F & Kaaks, R 2009, 'Genetic variation in genes of the fatty acid synthesis pathway and breast cancer risk', Breast Cancer Research and Treatment, vol. 118, n. 3, pagg. 565-574. https://doi.org/10.1007/s10549-009-0347-8

TY - JOUR

T1 - Genetic variation in genes of the fatty acid synthesis pathway and breast cancer risk

AU - Campa, Daniele

AU - McKay, James

AU - Sinilnikova, Olga

AU - Hüsing, Anika

AU - Vogel, Ulla

AU - Hansen, Rikke Dalgaard

AU - Overvad, Kim

AU - Witt, Petra Mariann

AU - Clavel-Chapelon, Françoise

AU - Boutron-Ruault, Marie Christine

AU - Chajes, Veronique

AU - Rohrmann, Sabine

AU - Chang-Claude, Jenny

AU - Boeing, Heiner

AU - Fisher, Eva

AU - Trichopoulou, Antonia

AU - Trichopoulos, Dimitrios

AU - Palli, Domenico

AU - Villarini, Anna

AU - Sacerdote, Carlotta

AU - Mattiello, Amalia

AU - Tumino, Rosario

AU - Peeters, Petra H.M.

AU - Van Gils, Carla H.

AU - Bas Bueno-De-Mesquita, H.

AU - Lund, Eiliv

AU - Chirlaque, María Dolores

AU - Sala, Núria

AU - Suarez, Laudina Rodriguez

AU - Barricarte, Aurelio

AU - Dorronsoro, Miren

AU - Sánchez, Maria José

AU - Lenner, Per

AU - Hallmans, Göran

AU - Tsilidis, Kostas

AU - Bingham, Sheila

AU - Khaw, Kay Tee

AU - Gallo, Valentina

AU - Norat, Teresa

AU - Riboli, Elio

AU - Rinaldi, Sabina

AU - Lenoir, Gilbert

AU - Tavtigian, Sean V.

AU - Canzian, Federico

AU - Kaaks, Rudolf

PY - 2009/12

Y1 - 2009/12

N2 - Fatty acid synthase (FAS) is the major enzyme of lipogenesis. It catalyzes the NADPH-dependent condensation of acetyl-CoA and malonyl-CoA to produce palmitic acid. Transcription of the FAS gene is controlled synergistically by the transcription factors ChREBP (carbohydrate response element-binding protein), which is induced by glucose, and SREBP-1 (sterol response element-binding protein-1), which is stimulated by insulin through the PI3K/Akt signal transduction pathway. We investigated whether the genetic variability of the genes encoding for ChREBP, SREBP and FAS (respectively, MLXIPL, SREBF1 and FASN) is related to breast cancer risk and body-mass index (BMI) by studying 1,294 breast cancer cases and 2,452 controls from the European Prospective Investigation on Cancer (EPIC). We resequenced the FAS gene and combined information of SNPs found by resequencing and SNPs from public databases. Using a tagging approach and selecting 20 SNPs, we covered all the common genetic variation of these genes. In this study we were not able to find any statistically significant association between the SNPs in the FAS, ChREBP and SREPB-1 genes and an increased risk of breast cancer overall and by subgroups of age, menopausal status, hormone replacement therapy (HRT) use or BMI. On the other hand, we found that two SNPs in FASN were associated with BMI.

AB - Fatty acid synthase (FAS) is the major enzyme of lipogenesis. It catalyzes the NADPH-dependent condensation of acetyl-CoA and malonyl-CoA to produce palmitic acid. Transcription of the FAS gene is controlled synergistically by the transcription factors ChREBP (carbohydrate response element-binding protein), which is induced by glucose, and SREBP-1 (sterol response element-binding protein-1), which is stimulated by insulin through the PI3K/Akt signal transduction pathway. We investigated whether the genetic variability of the genes encoding for ChREBP, SREBP and FAS (respectively, MLXIPL, SREBF1 and FASN) is related to breast cancer risk and body-mass index (BMI) by studying 1,294 breast cancer cases and 2,452 controls from the European Prospective Investigation on Cancer (EPIC). We resequenced the FAS gene and combined information of SNPs found by resequencing and SNPs from public databases. Using a tagging approach and selecting 20 SNPs, we covered all the common genetic variation of these genes. In this study we were not able to find any statistically significant association between the SNPs in the FAS, ChREBP and SREPB-1 genes and an increased risk of breast cancer overall and by subgroups of age, menopausal status, hormone replacement therapy (HRT) use or BMI. On the other hand, we found that two SNPs in FASN were associated with BMI.

KW - Body-mass index

KW - Breast cancer

KW - Carbohydrate response element-binding protein

KW - Fatty acid synthase

KW - Sterol response element-binding protein-1

KW - Susceptibility to cancer

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U2 - 10.1007/s10549-009-0347-8

DO - 10.1007/s10549-009-0347-8

M3 - Article

SN - 0167-6806

VL - 118

SP - 565

EP - 574

JO - Breast Cancer Research and Treatment

JF - Breast Cancer Research and Treatment

IS - 3

ER -

Genetic variation in genes of the fatty acid synthesis pathway and breast cancer risk

Abstract

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