Genetic variability of the fatty acid synthase pathway is not associated with prostate cancer risk in the European Prospective Investigation on Cancer (EPIC)

Daniele Campa; Anika Hüsing; Jenny Chang-Claude; Lucie Dostal; Heiner Boeing; Janine Kröger; Anne Tjønneland; Nina Roswall; Kim Overvad; Christina C. Dahm; Laudina Rodríguez; Núria Sala; Maria José Sánchez Pérez; Nerea Larrañaga; Maria Dolores Chirlaque; Eva Ardanaz; Kay Tee Khaw; Nick Wareham; Naomi E. Allen; Ruth C. Travis; Antonia Trichopoulou; Androniki Naska; Christina Bamia; Domenico Palli; Sabina Sieri; Rosario Tumino; Carlotta Sacerdote; Henk J. Van Kranen; H. Bas Bueno-De-Mesquita; Pär Stattin; Mattias Johansson; Veronique Chajes; Sabina Rinaldi; Isabelle Romieu; Afshan Siddiq; Teresa Norat; Elio Riboli; Rudolf Kaaks; Federico Canzian

doi:10.1016/j.ejca.2010.09.029

Genetic variability of the fatty acid synthase pathway is not associated with prostate cancer risk in the European Prospective Investigation on Cancer (EPIC)

Daniele Campa, Anika Hüsing, Jenny Chang-Claude, Lucie Dostal, Heiner Boeing, Janine Kröger, Anne Tjønneland, Nina Roswall, Kim Overvad, Christina C. Dahm, Laudina Rodríguez, Núria Sala, Maria José Sánchez Pérez, Nerea Larrañaga, Maria Dolores Chirlaque, Eva Ardanaz, Kay Tee Khaw, Nick Wareham, Naomi E. Allen, Ruth C. TravisAntonia Trichopoulou, Androniki Naska, Christina Bamia, Domenico Palli, Sabina Sieri, Rosario Tumino, Carlotta Sacerdote, Henk J. Van Kranen, H. Bas Bueno-De-Mesquita, Pär Stattin, Mattias Johansson, Veronique Chajes, Sabina Rinaldi, Isabelle Romieu, Afshan Siddiq, Teresa Norat, Elio Riboli, Rudolf Kaaks, Federico Canzian

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

A western lifestyle, characterised by low rates of energy expenditure and a high-energy diet rich in animal protein, saturated fats and refined carbohydrates, is associated with high incidence of prostate cancer in men. A high-energy nutritional status results in insulin/IGF signalling in cells, which in turn stimulates synthesis of fatty acids. We investigated whether the genetic variability of the genes belonging to the fatty acid synthesis pathway is related to prostate cancer risk in 815 prostate cancer cases and 1266 controls from the European Prospective Investigation on Cancer (EPIC). Using a tagging approach and selecting 252 SNPs in 22 genes, we covered all the common genetic variation of this pathway. None of the SNPs reached statistical significance after adjusting for multiple comparisons. Common SNPs in the fatty acid synthase pathway are not major contributors to prostate cancer risk.

Lingua originale	Inglese
pagine (da-a)	420-427
Numero di pagine	8
Rivista	European Journal of Cancer
Volume	47
Numero di pubblicazione	3
DOI	https://doi.org/10.1016/j.ejca.2010.09.029
Stato di pubblicazione	Pubblicato - feb 2011
Pubblicato esternamente	Sì

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10.1016/j.ejca.2010.09.029

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Campa, D., Hüsing, A., Chang-Claude, J., Dostal, L., Boeing, H., Kröger, J., Tjønneland, A., Roswall, N., Overvad, K., Dahm, C. C., Rodríguez, L., Sala, N., Pérez, M. J. S., Larrañaga, N., Chirlaque, M. D., Ardanaz, E., Khaw, K. T., Wareham, N., Allen, N. E., ... Canzian, F. (2011). Genetic variability of the fatty acid synthase pathway is not associated with prostate cancer risk in the European Prospective Investigation on Cancer (EPIC). European Journal of Cancer, 47(3), 420-427. https://doi.org/10.1016/j.ejca.2010.09.029

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title = "Genetic variability of the fatty acid synthase pathway is not associated with prostate cancer risk in the European Prospective Investigation on Cancer (EPIC)",

abstract = "A western lifestyle, characterised by low rates of energy expenditure and a high-energy diet rich in animal protein, saturated fats and refined carbohydrates, is associated with high incidence of prostate cancer in men. A high-energy nutritional status results in insulin/IGF signalling in cells, which in turn stimulates synthesis of fatty acids. We investigated whether the genetic variability of the genes belonging to the fatty acid synthesis pathway is related to prostate cancer risk in 815 prostate cancer cases and 1266 controls from the European Prospective Investigation on Cancer (EPIC). Using a tagging approach and selecting 252 SNPs in 22 genes, we covered all the common genetic variation of this pathway. None of the SNPs reached statistical significance after adjusting for multiple comparisons. Common SNPs in the fatty acid synthase pathway are not major contributors to prostate cancer risk.",

keywords = "Fatty acid synthase, Genetic polymorphisms, Prostate cancer, Susceptibility to cancer",

author = "Daniele Campa and Anika H{\"u}sing and Jenny Chang-Claude and Lucie Dostal and Heiner Boeing and Janine Kr{\"o}ger and Anne Tj{\o}nneland and Nina Roswall and Kim Overvad and Dahm, \{Christina C.\} and Laudina Rodr{\'i}guez and N{\'u}ria Sala and P{\'e}rez, \{Maria Jos{\'e} S{\'a}nchez\} and Nerea Larra{\~n}aga and Chirlaque, \{Maria Dolores\} and Eva Ardanaz and Khaw, \{Kay Tee\} and Nick Wareham and Allen, \{Naomi E.\} and Travis, \{Ruth C.\} and Antonia Trichopoulou and Androniki Naska and Christina Bamia and Domenico Palli and Sabina Sieri and Rosario Tumino and Carlotta Sacerdote and \{Van Kranen\}, \{Henk J.\} and \{Bas Bueno-De-Mesquita\}, H. and P{\"a}r Stattin and Mattias Johansson and Veronique Chajes and Sabina Rinaldi and Isabelle Romieu and Afshan Siddiq and Teresa Norat and Elio Riboli and Rudolf Kaaks and Federico Canzian",

year = "2011",

month = feb,

doi = "10.1016/j.ejca.2010.09.029",

language = "English",

volume = "47",

pages = "420--427",

journal = "European Journal of Cancer",

issn = "0959-8049",

publisher = "Elsevier Ltd.",

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}

Campa, D, Hüsing, A, Chang-Claude, J, Dostal, L, Boeing, H, Kröger, J, Tjønneland, A, Roswall, N, Overvad, K, Dahm, CC, Rodríguez, L, Sala, N, Pérez, MJS, Larrañaga, N, Chirlaque, MD, Ardanaz, E, Khaw, KT, Wareham, N, Allen, NE, Travis, RC, Trichopoulou, A, Naska, A, Bamia, C, Palli, D, Sieri, S, Tumino, R, Sacerdote, C, Van Kranen, HJ, Bas Bueno-De-Mesquita, H, Stattin, P, Johansson, M, Chajes, V, Rinaldi, S, Romieu, I, Siddiq, A, Norat, T, Riboli, E, Kaaks, R & Canzian, F 2011, 'Genetic variability of the fatty acid synthase pathway is not associated with prostate cancer risk in the European Prospective Investigation on Cancer (EPIC)', European Journal of Cancer, vol. 47, n. 3, pagg. 420-427. https://doi.org/10.1016/j.ejca.2010.09.029

Genetic variability of the fatty acid synthase pathway is not associated with prostate cancer risk in the European Prospective Investigation on Cancer (EPIC). / Campa, Daniele; Hüsing, Anika; Chang-Claude, Jenny et al.
In: European Journal of Cancer, Vol. 47, N. 3, 02.2011, pag. 420-427.

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

TY - JOUR

T1 - Genetic variability of the fatty acid synthase pathway is not associated with prostate cancer risk in the European Prospective Investigation on Cancer (EPIC)

AU - Campa, Daniele

AU - Hüsing, Anika

AU - Chang-Claude, Jenny

AU - Dostal, Lucie

AU - Boeing, Heiner

AU - Kröger, Janine

AU - Tjønneland, Anne

AU - Roswall, Nina

AU - Overvad, Kim

AU - Dahm, Christina C.

AU - Rodríguez, Laudina

AU - Sala, Núria

AU - Pérez, Maria José Sánchez

AU - Larrañaga, Nerea

AU - Chirlaque, Maria Dolores

AU - Ardanaz, Eva

AU - Khaw, Kay Tee

AU - Wareham, Nick

AU - Allen, Naomi E.

AU - Travis, Ruth C.

AU - Trichopoulou, Antonia

AU - Naska, Androniki

AU - Bamia, Christina

AU - Palli, Domenico

AU - Sieri, Sabina

AU - Tumino, Rosario

AU - Sacerdote, Carlotta

AU - Van Kranen, Henk J.

AU - Bas Bueno-De-Mesquita, H.

AU - Stattin, Pär

AU - Johansson, Mattias

AU - Chajes, Veronique

AU - Rinaldi, Sabina

AU - Romieu, Isabelle

AU - Siddiq, Afshan

AU - Norat, Teresa

AU - Riboli, Elio

AU - Kaaks, Rudolf

AU - Canzian, Federico

PY - 2011/2

Y1 - 2011/2

N2 - A western lifestyle, characterised by low rates of energy expenditure and a high-energy diet rich in animal protein, saturated fats and refined carbohydrates, is associated with high incidence of prostate cancer in men. A high-energy nutritional status results in insulin/IGF signalling in cells, which in turn stimulates synthesis of fatty acids. We investigated whether the genetic variability of the genes belonging to the fatty acid synthesis pathway is related to prostate cancer risk in 815 prostate cancer cases and 1266 controls from the European Prospective Investigation on Cancer (EPIC). Using a tagging approach and selecting 252 SNPs in 22 genes, we covered all the common genetic variation of this pathway. None of the SNPs reached statistical significance after adjusting for multiple comparisons. Common SNPs in the fatty acid synthase pathway are not major contributors to prostate cancer risk.

AB - A western lifestyle, characterised by low rates of energy expenditure and a high-energy diet rich in animal protein, saturated fats and refined carbohydrates, is associated with high incidence of prostate cancer in men. A high-energy nutritional status results in insulin/IGF signalling in cells, which in turn stimulates synthesis of fatty acids. We investigated whether the genetic variability of the genes belonging to the fatty acid synthesis pathway is related to prostate cancer risk in 815 prostate cancer cases and 1266 controls from the European Prospective Investigation on Cancer (EPIC). Using a tagging approach and selecting 252 SNPs in 22 genes, we covered all the common genetic variation of this pathway. None of the SNPs reached statistical significance after adjusting for multiple comparisons. Common SNPs in the fatty acid synthase pathway are not major contributors to prostate cancer risk.

KW - Fatty acid synthase

KW - Genetic polymorphisms

KW - Prostate cancer

KW - Susceptibility to cancer

UR - http://www.scopus.com/inward/record.url?scp=79251596084&partnerID=8YFLogxK

U2 - 10.1016/j.ejca.2010.09.029

DO - 10.1016/j.ejca.2010.09.029

M3 - Article

SN - 0959-8049

VL - 47

SP - 420

EP - 427

JO - European Journal of Cancer

JF - European Journal of Cancer

IS - 3

ER -

Genetic variability of the fatty acid synthase pathway is not associated with prostate cancer risk in the European Prospective Investigation on Cancer (EPIC)

Abstract

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