TY - JOUR
T1 - Genetic risk factors in primary paediatric versus adult headache
T2 - Complexities and problematics
AU - Lisi, Veronica
AU - Garbo, Greta
AU - Miccichè, Flavia
AU - Stecca, Anna
AU - Terrazzino, Salvatore
AU - Franzoi, Malida
AU - Tripoli, Elisa
AU - Clementi, Maurizio
AU - Leon, Alberta
AU - Battistella, Pier Antonio
PY - 2005/9
Y1 - 2005/9
N2 - Numerous candidate genes for migraine have been proposed on the basis of their possible functional role in its pathogenesis. Genetic polymorphisms have been evaluated in association studies, some of which have been suggested to be susceptibility markers for adult migraine. To date, however, none of the identified polymorphisms in adult migraine susceptibility have been investigated in children, raising the possibility that they may not be necessarily involved in paediatric migraine susceptibility. This paper reviews studies of the genetic basis of migraine and summarises our experience ingenetic association studies in primary paediatric headache susceptibility.
AB - Numerous candidate genes for migraine have been proposed on the basis of their possible functional role in its pathogenesis. Genetic polymorphisms have been evaluated in association studies, some of which have been suggested to be susceptibility markers for adult migraine. To date, however, none of the identified polymorphisms in adult migraine susceptibility have been investigated in children, raising the possibility that they may not be necessarily involved in paediatric migraine susceptibility. This paper reviews studies of the genetic basis of migraine and summarises our experience ingenetic association studies in primary paediatric headache susceptibility.
KW - Endothelin type A receptor
KW - Paediatric migraine
KW - Polymorphism
KW - Susceptibility
UR - http://www.scopus.com/inward/record.url?scp=25144468852&partnerID=8YFLogxK
U2 - 10.1007/s10194-005-0178-x
DO - 10.1007/s10194-005-0178-x
M3 - Article
SN - 1129-2369
VL - 6
SP - 179
EP - 181
JO - Journal of Headache and Pain
JF - Journal of Headache and Pain
IS - 4
ER -