Genetic interaction of CTLA-4 with HLA-DR15 in multiple sclerosis patients

Mehdi Alizadeh, Marie Claude Babron, Brigitte Birebent, Fumihiko Matsuda, Erwann Quelvennec, Roland Liblau, Isabelle Cournu-Rebeix, Patricia Momigliano-Richiardi, Jorge Sequeiros, Jacqueline Yaouanq, Emmanuelle Genin, Alexandre Vasilescu, Héloise Bougerie, Maria Trojano, Berta Martins Silva, Patricia Maciel, Françoise Clerget-Darpoux, Michel Clanet, Gilles Edan, Bertrand FontaineGilbert Semana

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

Multiple sclerosis is a chronic inflammatory disease of the central nervous system with a genetic component. Until now, the more consistent association with the disease is found with the major histocompatibility complex, especially HLA-DRB1*1501-DQB1*0602 haplotype. In this report, we demonstrate the interaction of Cytotoxic T Lymphocyte-associated antigen 4 (CTLA-4 [CD152]) gene with DRB1*15 haplotype in multiple sclerosis genetic susceptibility. Our data were obtained from two European independent family-based studies including 610 multiple sclerosis family trios.

Lingua originaleInglese
pagine (da-a)119-122
Numero di pagine4
RivistaAnnals of Neurology
Volume54
Numero di pubblicazione1
DOI
Stato di pubblicazionePubblicato - 1 lug 2003
Pubblicato esternamente

Fingerprint

Entra nei temi di ricerca di 'Genetic interaction of CTLA-4 with HLA-DR15 in multiple sclerosis patients'. Insieme formano una fingerprint unica.

Cita questo