Genetic analyses of gynecological disease identify genetic relationships between uterine fibroids and endometrial cancer, and a novel endometrial cancer genetic risk region at the WNT4 1p36.12 locus

P. F. Kho; S. Mortlock; F. Amant; D. Annibali; K. Ashton; J. Attia; P. L. Auer; M. W. Beckmann; A. Black; L. Brinton; D. D. Buchanan; S. J. Chanock; C. Chen; M. M. Chen; T. H. T. Cheng; L. S. Cook; M. Crous-Bous; K. Czene; I. Vivo; J. Dennis; T. Dork; S. C. Dowdy; A. M. Dunning; M. Durst; D. F. Easton; A. B. Ekici; P. A. Fasching; B. L. Fridley; C. M. Friedenreich; M. Garcia-Closas; M. M. Gaudet; G. G. Giles; E. L. Goode; C. A. Haiman; P. Hall; S. E. Hankinson; C. S. Healey; A. Hein; P. Hillemanns; S. Hodgson; E. Hoivik; E. G. Holliday; D. J. Hunter; A. Jones; P. Kraft; C. Krakstad; D. Lambrechts; L. Marchand; X. Liang; A. Lindblom; J. Lissowska; J. Long; L. Lu; A. M. Magliocco; L. Martin; M. McEvoy; R. L. Milne; M. Mints; R. Nassir; I. Orlow; G. Otton; C. Palles; P. D. P. Pharoah; L. Pooler; T. Proietto; T. R. Rebbeck; S. P. Renner; H. A. Risch; M. Rubner; I. Runnebaum; Carlotta SACERDOTE; G. E. Sarto; F. Schumacher; R. J. Scott; V. W. Setiawan; M. Shah; X. Sheng; Shu X. -O.; M. C. Southey; E. Tham; D. J. Thompson; I. Tomlinson; J. Trovik; C. Turman; D. Berg; Z. Wang; P. M. Webb; N. Wentzensen; S. J. Winham; L. Xia; Xiang Y. -B.; H. P. Yang; H. Yu; W. Zheng; Y. Sapkota; V. Steinthorsdottir; A. P. Morris; A. Fassbender; N. Rahmioglu; I. Vivo; J. E. Buring; F. Zhang; T. L. Edwards; S. Jones; O. Dorien; D. Peterse; K. M. Rexrode; P. M. Ridker; A. J. Schork; S. MacGregor; N. G. Martin; C. M. Becker; S. Adachi; K. Yoshihara; T. Enomoto; A. Takahashi; Y. Kamatani; K. Matsuda; M. Kubo; G. Thorleifsson; R. T. Geirsson; U. Thorsteinsdottir; L. M. Wallace; J. Yang; R. Digna; M. Nyegaard; Low S. -K.; K. T. Zondervan; S. A. Missmer; T. D'Hooghe; D. I. Chasman; K. Stefansson; J. Y. Tung; P. A. W. Rogers; D. R. Nyholt; A. B. Spurdle; D. M. Glubb; T. A. O'Mara

doi:10.1007/s00439-021-02312-0

Genetic analyses of gynecological disease identify genetic relationships between uterine fibroids and endometrial cancer, and a novel endometrial cancer genetic risk region at the WNT4 1p36.12 locus

P. F. Kho, S. Mortlock, F. Amant, D. Annibali, K. Ashton, J. Attia, P. L. Auer, M. W. Beckmann, A. Black, L. Brinton, D. D. Buchanan, S. J. Chanock, C. Chen, M. M. Chen, T. H. T. Cheng, L. S. Cook, M. Crous-Bous, K. Czene, I. Vivo, J. DennisT. Dork, S. C. Dowdy, A. M. Dunning, M. Durst, D. F. Easton, A. B. Ekici, P. A. Fasching, B. L. Fridley, C. M. Friedenreich, M. Garcia-Closas, M. M. Gaudet, G. G. Giles, E. L. Goode, C. A. Haiman, P. Hall, S. E. Hankinson, C. S. Healey, A. Hein, P. Hillemanns, S. Hodgson, E. Hoivik, E. G. Holliday, D. J. Hunter, A. Jones, P. Kraft, C. Krakstad, D. Lambrechts, L. Marchand, X. Liang, A. Lindblom, J. Lissowska, J. Long, L. Lu, A. M. Magliocco, L. Martin, M. McEvoy, R. L. Milne, M. Mints, R. Nassir, I. Orlow, G. Otton, C. Palles, P. D. P. Pharoah, L. Pooler, T. Proietto, T. R. Rebbeck, S. P. Renner, H. A. Risch, M. Rubner, I. Runnebaum, Carlotta SACERDOTE, G. E. Sarto, F. Schumacher, R. J. Scott, V. W. Setiawan, M. Shah, X. Sheng, Shu X. -O., M. C. Southey, E. Tham, D. J. Thompson, I. Tomlinson, J. Trovik, C. Turman, D. Berg, Z. Wang, P. M. Webb, N. Wentzensen, S. J. Winham, L. Xia, Xiang Y. -B., H. P. Yang, H. Yu, W. Zheng, Y. Sapkota, V. Steinthorsdottir, A. P. Morris, A. Fassbender, N. Rahmioglu, I. Vivo, J. E. Buring, F. Zhang, T. L. Edwards, S. Jones, O. Dorien, D. Peterse, K. M. Rexrode, P. M. Ridker, A. J. Schork, S. MacGregor, N. G. Martin, C. M. Becker, S. Adachi, K. Yoshihara, T. Enomoto, A. Takahashi, Y. Kamatani, K. Matsuda, M. Kubo, G. Thorleifsson, R. T. Geirsson, U. Thorsteinsdottir, L. M. Wallace, J. Yang, R. Digna, M. Nyegaard, Low S. -K., K. T. Zondervan, S. A. Missmer, T. D'Hooghe, D. I. Chasman, K. Stefansson, J. Y. Tung, P. A. W. Rogers, D. R. Nyholt, A. B. Spurdle, D. M. Glubb, T. A. O'Mara

Dipartimento di Scienze della Salute

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Endometriosis, polycystic ovary syndrome (PCOS) and uterine fibroids have been proposed as endometrial cancer risk factors; however, disentangling their relationships with endometrial cancer is complicated due to shared risk factors and comorbidities. Using genome-wide association study (GWAS) data, we explored the relationships between these non-cancerous gynecological diseases and endometrial cancer risk by assessing genetic correlation, causal relationships and shared risk loci. We found significant genetic correlation between endometrial cancer and PCOS, and uterine fibroids. Adjustment for genetically predicted body mass index (a risk factor for PCOS, uterine fibroids and endometrial cancer) substantially attenuated the genetic correlation between endometrial cancer and PCOS but did not affect the correlation with uterine fibroids. Mendelian randomization analyses suggested a causal relationship between only uterine fibroids and endometrial cancer. Gene-based analyses revealed risk regions shared between endometrial cancer and endometriosis, and uterine fibroids. Multi-trait GWAS analysis of endometrial cancer and the genetically correlated gynecological diseases identified a novel genome-wide significant endometrial cancer risk locus at 1p36.12, which replicated in an independent endometrial cancer dataset. Interrogation of functional genomic data at 1p36.12 revealed biologically relevant genes, including WNT4 which is necessary for the development of the female reproductive system. In summary, our study provides genetic evidence for a causal relationship between uterine fibroids and endometrial cancer. It further provides evidence that the comorbidity of endometrial cancer, PCOS and uterine fibroids may partly be due to shared genetic architecture. Notably, this shared architecture has revealed a novel genome-wide risk locus for endometrial cancer.

Lingua originale	Inglese
pagine (da-a)	1353-1365
Numero di pagine	13
Rivista	Human Genetics
Volume	140
Numero di pubblicazione	9
DOI	https://doi.org/10.1007/s00439-021-02312-0
Stato di pubblicazione	Pubblicato - 2021

OSS delle Nazioni Unite

Questo processo contribuisce al raggiungimento dei seguenti obiettivi di sviluppo sostenibile

Accesso al documento

10.1007/s00439-021-02312-0

https://hdl.handle.net/11579/199641

Altri file e collegamenti

handle

Cita questo

Kho, P. F., Mortlock, S., Amant, F., Annibali, D., Ashton, K., Attia, J., Auer, P. L., Beckmann, M. W., Black, A., Brinton, L., Buchanan, D. D., Chanock, S. J., Chen, C., Chen, M. M., Cheng, T. H. T., Cook, L. S., Crous-Bous, M., Czene, K., Vivo, I., ... O'Mara, T. A. (2021). Genetic analyses of gynecological disease identify genetic relationships between uterine fibroids and endometrial cancer, and a novel endometrial cancer genetic risk region at the WNT4 1p36.12 locus. Human Genetics, 140(9), 1353-1365. https://doi.org/10.1007/s00439-021-02312-0

@article{16fcdb073dd644898ef99792580ac58f,

title = "Genetic analyses of gynecological disease identify genetic relationships between uterine fibroids and endometrial cancer, and a novel endometrial cancer genetic risk region at the WNT4 1p36.12 locus",

abstract = "Endometriosis, polycystic ovary syndrome (PCOS) and uterine fibroids have been proposed as endometrial cancer risk factors; however, disentangling their relationships with endometrial cancer is complicated due to shared risk factors and comorbidities. Using genome-wide association study (GWAS) data, we explored the relationships between these non-cancerous gynecological diseases and endometrial cancer risk by assessing genetic correlation, causal relationships and shared risk loci. We found significant genetic correlation between endometrial cancer and PCOS, and uterine fibroids. Adjustment for genetically predicted body mass index (a risk factor for PCOS, uterine fibroids and endometrial cancer) substantially attenuated the genetic correlation between endometrial cancer and PCOS but did not affect the correlation with uterine fibroids. Mendelian randomization analyses suggested a causal relationship between only uterine fibroids and endometrial cancer. Gene-based analyses revealed risk regions shared between endometrial cancer and endometriosis, and uterine fibroids. Multi-trait GWAS analysis of endometrial cancer and the genetically correlated gynecological diseases identified a novel genome-wide significant endometrial cancer risk locus at 1p36.12, which replicated in an independent endometrial cancer dataset. Interrogation of functional genomic data at 1p36.12 revealed biologically relevant genes, including WNT4 which is necessary for the development of the female reproductive system. In summary, our study provides genetic evidence for a causal relationship between uterine fibroids and endometrial cancer. It further provides evidence that the comorbidity of endometrial cancer, PCOS and uterine fibroids may partly be due to shared genetic architecture. Notably, this shared architecture has revealed a novel genome-wide risk locus for endometrial cancer.",

author = "Kho, {P. F.} and S. Mortlock and F. Amant and D. Annibali and K. Ashton and J. Attia and Auer, {P. L.} and Beckmann, {M. W.} and A. Black and L. Brinton and Buchanan, {D. D.} and Chanock, {S. J.} and C. Chen and Chen, {M. M.} and Cheng, {T. H. T.} and Cook, {L. S.} and M. Crous-Bous and K. Czene and I. Vivo and J. Dennis and T. Dork and Dowdy, {S. C.} and Dunning, {A. M.} and M. Durst and Easton, {D. F.} and Ekici, {A. B.} and Fasching, {P. A.} and Fridley, {B. L.} and Friedenreich, {C. M.} and M. Garcia-Closas and Gaudet, {M. M.} and Giles, {G. G.} and Goode, {E. L.} and Haiman, {C. A.} and P. Hall and Hankinson, {S. E.} and Healey, {C. S.} and A. Hein and P. Hillemanns and S. Hodgson and E. Hoivik and Holliday, {E. G.} and Hunter, {D. J.} and A. Jones and P. Kraft and C. Krakstad and D. Lambrechts and L. Marchand and X. Liang and A. Lindblom and J. Lissowska and J. Long and L. Lu and Magliocco, {A. M.} and L. Martin and M. McEvoy and Milne, {R. L.} and M. Mints and R. Nassir and I. Orlow and G. Otton and C. Palles and Pharoah, {P. D. P.} and L. Pooler and T. Proietto and Rebbeck, {T. R.} and Renner, {S. P.} and Risch, {H. A.} and M. Rubner and I. Runnebaum and Carlotta SACERDOTE and Sarto, {G. E.} and F. Schumacher and Scott, {R. J.} and Setiawan, {V. W.} and M. Shah and X. Sheng and -O., {Shu X.} and Southey, {M. C.} and E. Tham and Thompson, {D. J.} and I. Tomlinson and J. Trovik and C. Turman and D. Berg and Z. Wang and Webb, {P. M.} and N. Wentzensen and Winham, {S. J.} and L. Xia and -B., {Xiang Y.} and Yang, {H. P.} and H. Yu and W. Zheng and Y. Sapkota and V. Steinthorsdottir and Morris, {A. P.} and A. Fassbender and N. Rahmioglu and I. Vivo and Buring, {J. E.} and F. Zhang and Edwards, {T. L.} and S. Jones and O. Dorien and D. Peterse and Rexrode, {K. M.} and Ridker, {P. M.} and Schork, {A. J.} and S. MacGregor and Martin, {N. G.} and Becker, {C. M.} and S. Adachi and K. Yoshihara and T. Enomoto and A. Takahashi and Y. Kamatani and K. Matsuda and M. Kubo and G. Thorleifsson and Geirsson, {R. T.} and U. Thorsteinsdottir and Wallace, {L. M.} and J. Yang and R. Digna and M. Nyegaard and -K., {Low S.} and Zondervan, {K. T.} and Missmer, {S. A.} and T. D'Hooghe and Chasman, {D. I.} and K. Stefansson and Tung, {J. Y.} and Rogers, {P. A. W.} and Nyholt, {D. R.} and Spurdle, {A. B.} and Glubb, {D. M.} and O'Mara, {T. A.}",

year = "2021",

doi = "10.1007/s00439-021-02312-0",

language = "English",

volume = "140",

pages = "1353--1365",

journal = "Human Genetics",

issn = "0340-6717",

publisher = "Springer Science and Business Media Deutschland GmbH",

number = "9",

}

Kho, PF, Mortlock, S, Amant, F, Annibali, D, Ashton, K, Attia, J, Auer, PL, Beckmann, MW, Black, A, Brinton, L, Buchanan, DD, Chanock, SJ, Chen, C, Chen, MM, Cheng, THT, Cook, LS, Crous-Bous, M, Czene, K, Vivo, I, Dennis, J, Dork, T, Dowdy, SC, Dunning, AM, Durst, M, Easton, DF, Ekici, AB, Fasching, PA, Fridley, BL, Friedenreich, CM, Garcia-Closas, M, Gaudet, MM, Giles, GG, Goode, EL, Haiman, CA, Hall, P, Hankinson, SE, Healey, CS, Hein, A, Hillemanns, P, Hodgson, S, Hoivik, E, Holliday, EG, Hunter, DJ, Jones, A, Kraft, P, Krakstad, C, Lambrechts, D, Marchand, L, Liang, X, Lindblom, A, Lissowska, J, Long, J, Lu, L, Magliocco, AM, Martin, L, McEvoy, M, Milne, RL, Mints, M, Nassir, R, Orlow, I, Otton, G, Palles, C, Pharoah, PDP, Pooler, L, Proietto, T, Rebbeck, TR, Renner, SP, Risch, HA, Rubner, M, Runnebaum, I, SACERDOTE, C, Sarto, GE, Schumacher, F, Scott, RJ, Setiawan, VW, Shah, M, Sheng, X, -O., SX, Southey, MC, Tham, E, Thompson, DJ, Tomlinson, I, Trovik, J, Turman, C, Berg, D, Wang, Z, Webb, PM, Wentzensen, N, Winham, SJ, Xia, L, -B., XY, Yang, HP, Yu, H, Zheng, W, Sapkota, Y, Steinthorsdottir, V, Morris, AP, Fassbender, A, Rahmioglu, N, Vivo, I, Buring, JE, Zhang, F, Edwards, TL, Jones, S, Dorien, O, Peterse, D, Rexrode, KM, Ridker, PM, Schork, AJ, MacGregor, S, Martin, NG, Becker, CM, Adachi, S, Yoshihara, K, Enomoto, T, Takahashi, A, Kamatani, Y, Matsuda, K, Kubo, M, Thorleifsson, G, Geirsson, RT, Thorsteinsdottir, U, Wallace, LM, Yang, J, Digna, R, Nyegaard, M, -K., LS, Zondervan, KT, Missmer, SA, D'Hooghe, T, Chasman, DI, Stefansson, K, Tung, JY, Rogers, PAW, Nyholt, DR, Spurdle, AB, Glubb, DM & O'Mara, TA 2021, 'Genetic analyses of gynecological disease identify genetic relationships between uterine fibroids and endometrial cancer, and a novel endometrial cancer genetic risk region at the WNT4 1p36.12 locus', Human Genetics, vol. 140, n. 9, pagg. 1353-1365. https://doi.org/10.1007/s00439-021-02312-0

Genetic analyses of gynecological disease identify genetic relationships between uterine fibroids and endometrial cancer, and a novel endometrial cancer genetic risk region at the WNT4 1p36.12 locus. / Kho, P. F.; Mortlock, S.; Amant, F. et al.
In: Human Genetics, Vol. 140, N. 9, 2021, pag. 1353-1365.

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

TY - JOUR

T1 - Genetic analyses of gynecological disease identify genetic relationships between uterine fibroids and endometrial cancer, and a novel endometrial cancer genetic risk region at the WNT4 1p36.12 locus

AU - Kho, P. F.

AU - Mortlock, S.

AU - Amant, F.

AU - Annibali, D.

AU - Ashton, K.

AU - Attia, J.

AU - Auer, P. L.

AU - Beckmann, M. W.

AU - Black, A.

AU - Brinton, L.

AU - Buchanan, D. D.

AU - Chanock, S. J.

AU - Chen, C.

AU - Chen, M. M.

AU - Cheng, T. H. T.

AU - Cook, L. S.

AU - Crous-Bous, M.

AU - Czene, K.

AU - Vivo, I.

AU - Dennis, J.

AU - Dork, T.

AU - Dowdy, S. C.

AU - Dunning, A. M.

AU - Durst, M.

AU - Easton, D. F.

AU - Ekici, A. B.

AU - Fasching, P. A.

AU - Fridley, B. L.

AU - Friedenreich, C. M.

AU - Garcia-Closas, M.

AU - Gaudet, M. M.

AU - Giles, G. G.

AU - Goode, E. L.

AU - Haiman, C. A.

AU - Hall, P.

AU - Hankinson, S. E.

AU - Healey, C. S.

AU - Hein, A.

AU - Hillemanns, P.

AU - Hodgson, S.

AU - Hoivik, E.

AU - Holliday, E. G.

AU - Hunter, D. J.

AU - Jones, A.

AU - Kraft, P.

AU - Krakstad, C.

AU - Lambrechts, D.

AU - Marchand, L.

AU - Liang, X.

AU - Lindblom, A.

AU - Lissowska, J.

AU - Long, J.

AU - Lu, L.

AU - Magliocco, A. M.

AU - Martin, L.

AU - McEvoy, M.

AU - Milne, R. L.

AU - Mints, M.

AU - Nassir, R.

AU - Orlow, I.

AU - Otton, G.

AU - Palles, C.

AU - Pharoah, P. D. P.

AU - Pooler, L.

AU - Proietto, T.

AU - Rebbeck, T. R.

AU - Renner, S. P.

AU - Risch, H. A.

AU - Rubner, M.

AU - Runnebaum, I.

AU - SACERDOTE, Carlotta

AU - Sarto, G. E.

AU - Schumacher, F.

AU - Scott, R. J.

AU - Setiawan, V. W.

AU - Shah, M.

AU - Sheng, X.

AU - -O., Shu X.

AU - Southey, M. C.

AU - Tham, E.

AU - Thompson, D. J.

AU - Tomlinson, I.

AU - Trovik, J.

AU - Turman, C.

AU - Berg, D.

AU - Wang, Z.

AU - Webb, P. M.

AU - Wentzensen, N.

AU - Winham, S. J.

AU - Xia, L.

AU - -B., Xiang Y.

AU - Yang, H. P.

AU - Yu, H.

AU - Zheng, W.

AU - Sapkota, Y.

AU - Steinthorsdottir, V.

AU - Morris, A. P.

AU - Fassbender, A.

AU - Rahmioglu, N.

AU - Vivo, I.

AU - Buring, J. E.

AU - Zhang, F.

AU - Edwards, T. L.

AU - Jones, S.

AU - Dorien, O.

AU - Peterse, D.

AU - Rexrode, K. M.

AU - Ridker, P. M.

AU - Schork, A. J.

AU - MacGregor, S.

AU - Martin, N. G.

AU - Becker, C. M.

AU - Adachi, S.

AU - Yoshihara, K.

AU - Enomoto, T.

AU - Takahashi, A.

AU - Kamatani, Y.

AU - Matsuda, K.

AU - Kubo, M.

AU - Thorleifsson, G.

AU - Geirsson, R. T.

AU - Thorsteinsdottir, U.

AU - Wallace, L. M.

AU - Yang, J.

AU - Digna, R.

AU - Nyegaard, M.

AU - -K., Low S.

AU - Zondervan, K. T.

AU - Missmer, S. A.

AU - D'Hooghe, T.

AU - Chasman, D. I.

AU - Stefansson, K.

AU - Tung, J. Y.

AU - Rogers, P. A. W.

AU - Nyholt, D. R.

AU - Spurdle, A. B.

AU - Glubb, D. M.

AU - O'Mara, T. A.

PY - 2021

Y1 - 2021

N2 - Endometriosis, polycystic ovary syndrome (PCOS) and uterine fibroids have been proposed as endometrial cancer risk factors; however, disentangling their relationships with endometrial cancer is complicated due to shared risk factors and comorbidities. Using genome-wide association study (GWAS) data, we explored the relationships between these non-cancerous gynecological diseases and endometrial cancer risk by assessing genetic correlation, causal relationships and shared risk loci. We found significant genetic correlation between endometrial cancer and PCOS, and uterine fibroids. Adjustment for genetically predicted body mass index (a risk factor for PCOS, uterine fibroids and endometrial cancer) substantially attenuated the genetic correlation between endometrial cancer and PCOS but did not affect the correlation with uterine fibroids. Mendelian randomization analyses suggested a causal relationship between only uterine fibroids and endometrial cancer. Gene-based analyses revealed risk regions shared between endometrial cancer and endometriosis, and uterine fibroids. Multi-trait GWAS analysis of endometrial cancer and the genetically correlated gynecological diseases identified a novel genome-wide significant endometrial cancer risk locus at 1p36.12, which replicated in an independent endometrial cancer dataset. Interrogation of functional genomic data at 1p36.12 revealed biologically relevant genes, including WNT4 which is necessary for the development of the female reproductive system. In summary, our study provides genetic evidence for a causal relationship between uterine fibroids and endometrial cancer. It further provides evidence that the comorbidity of endometrial cancer, PCOS and uterine fibroids may partly be due to shared genetic architecture. Notably, this shared architecture has revealed a novel genome-wide risk locus for endometrial cancer.

AB - Endometriosis, polycystic ovary syndrome (PCOS) and uterine fibroids have been proposed as endometrial cancer risk factors; however, disentangling their relationships with endometrial cancer is complicated due to shared risk factors and comorbidities. Using genome-wide association study (GWAS) data, we explored the relationships between these non-cancerous gynecological diseases and endometrial cancer risk by assessing genetic correlation, causal relationships and shared risk loci. We found significant genetic correlation between endometrial cancer and PCOS, and uterine fibroids. Adjustment for genetically predicted body mass index (a risk factor for PCOS, uterine fibroids and endometrial cancer) substantially attenuated the genetic correlation between endometrial cancer and PCOS but did not affect the correlation with uterine fibroids. Mendelian randomization analyses suggested a causal relationship between only uterine fibroids and endometrial cancer. Gene-based analyses revealed risk regions shared between endometrial cancer and endometriosis, and uterine fibroids. Multi-trait GWAS analysis of endometrial cancer and the genetically correlated gynecological diseases identified a novel genome-wide significant endometrial cancer risk locus at 1p36.12, which replicated in an independent endometrial cancer dataset. Interrogation of functional genomic data at 1p36.12 revealed biologically relevant genes, including WNT4 which is necessary for the development of the female reproductive system. In summary, our study provides genetic evidence for a causal relationship between uterine fibroids and endometrial cancer. It further provides evidence that the comorbidity of endometrial cancer, PCOS and uterine fibroids may partly be due to shared genetic architecture. Notably, this shared architecture has revealed a novel genome-wide risk locus for endometrial cancer.

UR - https://iris.uniupo.it/handle/11579/199641

U2 - 10.1007/s00439-021-02312-0

DO - 10.1007/s00439-021-02312-0

M3 - Article

SN - 0340-6717

VL - 140

SP - 1353

EP - 1365

JO - Human Genetics

JF - Human Genetics

IS - 9

ER -

Genetic analyses of gynecological disease identify genetic relationships between uterine fibroids and endometrial cancer, and a novel endometrial cancer genetic risk region at the WNT4 1p36.12 locus

Abstract

OSS delle Nazioni Unite

Accesso al documento

Altri file e collegamenti

Fingerprint

Cita questo