Genes and Microbiota Interaction in Monogenic Autoimmune Disorders

Federica Costa, Eleonora Beltrami, Simona Mellone, Sara Sacchetti, Elena Boggio, Casimiro Luca Gigliotti, Ian Stoppa, Umberto Dianzani, Roberta Rolla, Mara Giordano

Risultato della ricerca: Contributo su rivistaArticolo di reviewpeer review

Abstract

Monogenic autoimmune disorders represent an important tool to understand the mechanisms behind central and peripheral immune tolerance. Multiple factors, both genetic and environmental, are known to be involved in the alteration of the immune activation/immune tolerance homeostasis typical of these disorders, making it difficult to control the disease. The latest advances in genetic analysis have contributed to a better and more rapid diagnosis, although the management remains confined to the treatment of clinical manifestations, as there are limited studies on rare diseases. Recently, the correlation between microbiota composition and the onset of autoimmune disorders has been investigated, thus opening up new perspectives on the cure of monogenic autoimmune diseases. In this review, we will summarize the main genetic features of both organ-specific and systemic monogenic autoimmune diseases, reporting on the available literature data on microbiota alterations in these patients.

Lingua originaleInglese
Numero di articolo1127
RivistaBiomedicines
Volume11
Numero di pubblicazione4
DOI
Stato di pubblicazionePubblicato - apr 2023

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