Gene expression and pathway bioinformatics analysis detect a potential predictive value of MAP3K8 in thyroid cancer progression

Valentina Di Salvatore; Fiorenza Giani; Giulia Russo; Marzio Pennisi; Pasqualino Malandrino; Francesco Frasca; Francesco Pappalardo

doi:10.1109/BIBM47256.2019.8983036

Gene expression and pathway bioinformatics analysis detect a potential predictive value of MAP3K8 in thyroid cancer progression

Valentina Di Salvatore
, Fiorenza Giani
, Giulia Russo
, Marzio Pennisi
, Pasqualino Malandrino
, Francesco Frasca
, Francesco Pappalardo

Risultato della ricerca: Capitolo in libro/report/atti di convegno › Contributo a conferenza › peer review

Abstract

Thyroid cancer is the commonest endocrine malignancy. Mutation in the BRAF serine/threonine kinase is the most frequent genetic alteration in thyroid cancer. Target therapy for advanced and poorly differentiated thyroid carcinomas include BRAF pathway inhibitors. Here, we evaluated the role of MAP3K8 expression as a potential driver of resistance to BRAF inhibition in thyroid cancer. By analyzing Gene Expression Omnibus data repository, across all thyroid cancer histotypes, we found that MAP3K8 is up-regulated in poorly differentiated thyroid carcinomas and its expression is related to a stem cell like phenotype and a poorer prognosis and survival. Taken together these data unravel a novel mechanism for thyroid cancer progression and chemo-resistance and confirm previous results obtained in cultured thyroid cancer stem cells.

Lingua originale	Inglese
Titolo della pubblicazione ospite	Proceedings - 2019 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2019
Editor	Illhoi Yoo, Jinbo Bi, Xiaohua Tony Hu
Editore	Institute of Electrical and Electronics Engineers Inc.
Pagine	2202-2206
Numero di pagine	5
ISBN (elettronico)	9781728118673
DOI	https://doi.org/10.1109/BIBM47256.2019.8983036
Stato di pubblicazione	Pubblicato - nov 2019
Pubblicato esternamente	Sì
Evento	2019 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2019 - San Diego, United States Durata: 18 nov 2019 → 21 nov 2019

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Nome	Proceedings - 2019 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2019

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???event.eventtypes.event.conference???	2019 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2019
Paese/Territorio	United States
Città	San Diego
Periodo	18/11/19 → 21/11/19

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10.1109/BIBM47256.2019.8983036

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Di Salvatore, V., Giani, F., Russo, G., Pennisi, M., Malandrino, P., Frasca, F., & Pappalardo, F. (2019). Gene expression and pathway bioinformatics analysis detect a potential predictive value of MAP3K8 in thyroid cancer progression. In I. Yoo, J. Bi, & X. T. Hu (Edd.), Proceedings - 2019 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2019 (pagg. 2202-2206). Articolo 8983036 (Proceedings - 2019 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2019). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/BIBM47256.2019.8983036

Di Salvatore, Valentina ; Giani, Fiorenza ; Russo, Giulia et al. / Gene expression and pathway bioinformatics analysis detect a potential predictive value of MAP3K8 in thyroid cancer progression. Proceedings - 2019 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2019. curatore / Illhoi Yoo ; Jinbo Bi ; Xiaohua Tony Hu. Institute of Electrical and Electronics Engineers Inc., 2019. pagg. 2202-2206 (Proceedings - 2019 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2019).

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title = "Gene expression and pathway bioinformatics analysis detect a potential predictive value of MAP3K8 in thyroid cancer progression",

abstract = "Thyroid cancer is the commonest endocrine malignancy. Mutation in the BRAF serine/threonine kinase is the most frequent genetic alteration in thyroid cancer. Target therapy for advanced and poorly differentiated thyroid carcinomas include BRAF pathway inhibitors. Here, we evaluated the role of MAP3K8 expression as a potential driver of resistance to BRAF inhibition in thyroid cancer. By analyzing Gene Expression Omnibus data repository, across all thyroid cancer histotypes, we found that MAP3K8 is up-regulated in poorly differentiated thyroid carcinomas and its expression is related to a stem cell like phenotype and a poorer prognosis and survival. Taken together these data unravel a novel mechanism for thyroid cancer progression and chemo-resistance and confirm previous results obtained in cultured thyroid cancer stem cells.",

keywords = "BRAF, MAP3K8, Thyroid cancer, pathway analysis",

author = "\{Di Salvatore\}, Valentina and Fiorenza Giani and Giulia Russo and Marzio Pennisi and Pasqualino Malandrino and Francesco Frasca and Francesco Pappalardo",

note = "Publisher Copyright: {\textcopyright} 2019 IEEE.; 2019 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2019 ; Conference date: 18-11-2019 Through 21-11-2019",

year = "2019",

month = nov,

doi = "10.1109/BIBM47256.2019.8983036",

language = "English",

series = "Proceedings - 2019 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2019",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

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Di Salvatore, V, Giani, F, Russo, G, Pennisi, M, Malandrino, P, Frasca, F & Pappalardo, F 2019, Gene expression and pathway bioinformatics analysis detect a potential predictive value of MAP3K8 in thyroid cancer progression. in I Yoo, J Bi & XT Hu (edd.), Proceedings - 2019 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2019., 8983036, Proceedings - 2019 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2019, Institute of Electrical and Electronics Engineers Inc., pagg. 2202-2206, 2019 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2019, San Diego, United States, 18/11/19. https://doi.org/10.1109/BIBM47256.2019.8983036

Gene expression and pathway bioinformatics analysis detect a potential predictive value of MAP3K8 in thyroid cancer progression. / Di Salvatore, Valentina; Giani, Fiorenza; Russo, Giulia et al.
Proceedings - 2019 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2019. a cura di / Illhoi Yoo; Jinbo Bi; Xiaohua Tony Hu. Institute of Electrical and Electronics Engineers Inc., 2019. pag. 2202-2206 8983036 (Proceedings - 2019 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2019).

Risultato della ricerca: Capitolo in libro/report/atti di convegno › Contributo a conferenza › peer review

TY - GEN

T1 - Gene expression and pathway bioinformatics analysis detect a potential predictive value of MAP3K8 in thyroid cancer progression

AU - Di Salvatore, Valentina

AU - Giani, Fiorenza

AU - Russo, Giulia

AU - Pennisi, Marzio

AU - Malandrino, Pasqualino

AU - Frasca, Francesco

AU - Pappalardo, Francesco

PY - 2019/11

Y1 - 2019/11

N2 - Thyroid cancer is the commonest endocrine malignancy. Mutation in the BRAF serine/threonine kinase is the most frequent genetic alteration in thyroid cancer. Target therapy for advanced and poorly differentiated thyroid carcinomas include BRAF pathway inhibitors. Here, we evaluated the role of MAP3K8 expression as a potential driver of resistance to BRAF inhibition in thyroid cancer. By analyzing Gene Expression Omnibus data repository, across all thyroid cancer histotypes, we found that MAP3K8 is up-regulated in poorly differentiated thyroid carcinomas and its expression is related to a stem cell like phenotype and a poorer prognosis and survival. Taken together these data unravel a novel mechanism for thyroid cancer progression and chemo-resistance and confirm previous results obtained in cultured thyroid cancer stem cells.

AB - Thyroid cancer is the commonest endocrine malignancy. Mutation in the BRAF serine/threonine kinase is the most frequent genetic alteration in thyroid cancer. Target therapy for advanced and poorly differentiated thyroid carcinomas include BRAF pathway inhibitors. Here, we evaluated the role of MAP3K8 expression as a potential driver of resistance to BRAF inhibition in thyroid cancer. By analyzing Gene Expression Omnibus data repository, across all thyroid cancer histotypes, we found that MAP3K8 is up-regulated in poorly differentiated thyroid carcinomas and its expression is related to a stem cell like phenotype and a poorer prognosis and survival. Taken together these data unravel a novel mechanism for thyroid cancer progression and chemo-resistance and confirm previous results obtained in cultured thyroid cancer stem cells.

KW - BRAF

KW - MAP3K8

KW - Thyroid cancer

KW - pathway analysis

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DO - 10.1109/BIBM47256.2019.8983036

M3 - Conference contribution

AN - SCOPUS:85084331561

T3 - Proceedings - 2019 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2019

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BT - Proceedings - 2019 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2019

A2 - Yoo, Illhoi

A2 - Bi, Jinbo

A2 - Hu, Xiaohua Tony

PB - Institute of Electrical and Electronics Engineers Inc.

T2 - 2019 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2019

Y2 - 18 November 2019 through 21 November 2019

ER -

Di Salvatore V, Giani F, Russo G, Pennisi M, Malandrino P, Frasca F et al. Gene expression and pathway bioinformatics analysis detect a potential predictive value of MAP3K8 in thyroid cancer progression. In Yoo I, Bi J, Hu XT, editor, Proceedings - 2019 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2019. Institute of Electrical and Electronics Engineers Inc. 2019. pag. 2202-2206. 8983036. (Proceedings - 2019 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2019). doi: 10.1109/BIBM47256.2019.8983036

Gene expression and pathway bioinformatics analysis detect a potential predictive value of MAP3K8 in thyroid cancer progression

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