TY - JOUR
T1 - Gender-specific influence of the chromosome 16 chemokine gene cluster on the susceptibility to Multiple Sclerosis
AU - Galimberti, Daniela
AU - Scalabrini, Diego
AU - Fenoglio, Chiara
AU - De Riz, Milena
AU - Comi, Cristoforo
AU - Venturelli, Eliana
AU - Cortini, Francesca
AU - Piola, Mirko
AU - Leone, Maurizio
AU - Dianzani, Umberto
AU - D'Alfonso, Sandra
AU - Monaco, Francesco
AU - Bresolin, Nereo
AU - Scarpini, Elio
N1 - Funding Information:
This work was supported by grants from Associazione “Amici del Centro Dino Ferrari”, IRCCS Ospedale Maggiore Milano, Monzino Foundation, Regione Piemonte/CIPE 2003 and Ing. Cesare Cusan.
PY - 2008/4/15
Y1 - 2008/4/15
N2 - Macrophage-derived chemokine (MDC/CCL22) plays a role in Experimental Autoimmune Encephalomyelitis (EAE), the animal model of Multiple Sclerosis (MS). MDC/CCL22 gene is part of a chemokine cluster, which includes also thymus and Activation-Regulated Chemokine (TARC/CCL17). The frequency of the C/T and C/A Single Nucleotide Polymorphisms (SNPs) in the promoter and coding sequence of CCL22 as well as the C/T SNP in the promoter of CCL17 were determined in 370 patients with Multiple Sclerosis (MS) compared with 380 controls. A trend towards a decreased allelic frequency of the A allele of the CCL22 C/A SNP as well as of the T allele of the CCL17 C/T SNP was found in patients compared with controls. The frequency of the AT haplotype was significantly decreased in MS patients (P = 0.017, OR: 0.49, CI: 0.28-0.87). Stratifying patients according to gender, the observed association was even more pronounced in male patients compared with male controls (P = 0.004, OR = 0.18, 95% CI: 0.06-0.50), whereas no significant differences were observed in females. Therefore, the presence of the AT haplotype in chromosome 16 chemokine cluster is likely to confer a decreased risk of developing MS, particularly in males.
AB - Macrophage-derived chemokine (MDC/CCL22) plays a role in Experimental Autoimmune Encephalomyelitis (EAE), the animal model of Multiple Sclerosis (MS). MDC/CCL22 gene is part of a chemokine cluster, which includes also thymus and Activation-Regulated Chemokine (TARC/CCL17). The frequency of the C/T and C/A Single Nucleotide Polymorphisms (SNPs) in the promoter and coding sequence of CCL22 as well as the C/T SNP in the promoter of CCL17 were determined in 370 patients with Multiple Sclerosis (MS) compared with 380 controls. A trend towards a decreased allelic frequency of the A allele of the CCL22 C/A SNP as well as of the T allele of the CCL17 C/T SNP was found in patients compared with controls. The frequency of the AT haplotype was significantly decreased in MS patients (P = 0.017, OR: 0.49, CI: 0.28-0.87). Stratifying patients according to gender, the observed association was even more pronounced in male patients compared with male controls (P = 0.004, OR = 0.18, 95% CI: 0.06-0.50), whereas no significant differences were observed in females. Therefore, the presence of the AT haplotype in chromosome 16 chemokine cluster is likely to confer a decreased risk of developing MS, particularly in males.
KW - Chemokines
KW - Haplotype
KW - MDC-CCL22
KW - Multiple Sclerosis (MS)
KW - Single Nucleotide Polymorphism (SNP)
UR - http://www.scopus.com/inward/record.url?scp=39049156297&partnerID=8YFLogxK
U2 - 10.1016/j.jns.2007.10.001
DO - 10.1016/j.jns.2007.10.001
M3 - Article
SN - 0022-510X
VL - 267
SP - 86
EP - 90
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
IS - 1-2
ER -