GdDOTAGA(C18)2: An efficient amphiphilic Gd(III) chelate for the preparation of self-assembled high relaxivity MRI nanoprobes

M. Filippi; D. Remotti; M. Botta; E. Terreno; L. Tei

doi:10.1039/c5cc06032j

GdDOTAGA(C₁₈)₂: An efficient amphiphilic Gd(III) chelate for the preparation of self-assembled high relaxivity MRI nanoprobes

M. Filippi
, D. Remotti
, M. Botta
, E. Terreno
, L. Tei

Dipartimento di Scienze e Innovazione Tecnologica

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

A new amphiphilic GdDOTA-like complex functionalized with two octadecyl chains was synthesised and incorporated into the bilayer of liposomes and dendrimersomes. ¹H NMR relaxometric studies and in vivo MRI experiments on mice bearing a syngeneic melanoma tumour have shown a great improvement in performance.

Lingua originale	Inglese
pagine (da-a)	17455-17458
Numero di pagine	4
Rivista	Chemical Communications
Volume	51
Numero di pubblicazione	98
DOI	https://doi.org/10.1039/c5cc06032j
Stato di pubblicazione	Pubblicato - 2015

Accesso al documento

10.1039/c5cc06032j

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Cita questo

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title = "GdDOTAGA(C18)2: An efficient amphiphilic Gd(III) chelate for the preparation of self-assembled high relaxivity MRI nanoprobes",

abstract = "A new amphiphilic GdDOTA-like complex functionalized with two octadecyl chains was synthesised and incorporated into the bilayer of liposomes and dendrimersomes. 1H NMR relaxometric studies and in vivo MRI experiments on mice bearing a syngeneic melanoma tumour have shown a great improvement in performance.",

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AB - A new amphiphilic GdDOTA-like complex functionalized with two octadecyl chains was synthesised and incorporated into the bilayer of liposomes and dendrimersomes. 1H NMR relaxometric studies and in vivo MRI experiments on mice bearing a syngeneic melanoma tumour have shown a great improvement in performance.

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