Gadolinium-loaded polychelating amphiphilic polymer as an enhanced MRI contrast agent for human multiple myeloma and non Hodgkin's lymphoma (human Burkitt's lymphoma)

Dorota Kozlowska; Swati Biswas; Eoin K. Fox; Bing Wu; Ferdia Bolster; Om Prakash Edupuganti; Vladimir Torchilin; Stephen Eustace; Mauro Botta; Richard O'Kennedy; Dermot F. Brougham

doi:10.1039/c3ra45400b

Gadolinium-loaded polychelating amphiphilic polymer as an enhanced MRI contrast agent for human multiple myeloma and non Hodgkin's lymphoma (human Burkitt's lymphoma)

Dorota Kozlowska, Swati Biswas, Eoin K. Fox, Bing Wu, Ferdia Bolster, Om Prakash Edupuganti, Vladimir Torchilin, Stephen Eustace, Mauro Botta, Richard O'Kennedy, Dermot F. Brougham

Dipartimento di Scienze e Innovazione Tecnologica

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Liposomes, loaded with gadolinium (Gd) ions using different membrane-incorporated chelating lipids and functionalized with monoclonal anti-CD138 (syndecan-1) antibody were prepared. Nuclear Magnetic Resonance Dispersion (NMRD) analysis showed that use of the polychelating amphiphilic polymer (PAP) increases both the Gd content and the spin-lattice relaxivity of the Gd-loaded-PAP-liposomes as compared to Gd-DTPA-BSA equivalents. The potential application of contrast syndecan-1- and Rituximab-liposomes, for application as a novel minimally invasive diagnostic agent for multiple myeloma and non Hodgkin's lymphoma was investigated.

Lingua originale	Inglese
pagine (da-a)	18007-18016
Numero di pagine	10
Rivista	RSC Advances
Volume	4
Numero di pubblicazione	35
DOI	https://doi.org/10.1039/c3ra45400b
Stato di pubblicazione	Pubblicato - 2014

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10.1039/c3ra45400b

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Kozlowska, D., Biswas, S., Fox, E. K., Wu, B., Bolster, F., Edupuganti, O. P., Torchilin, V., Eustace, S., Botta, M., O'Kennedy, R., & Brougham, D. F. (2014). Gadolinium-loaded polychelating amphiphilic polymer as an enhanced MRI contrast agent for human multiple myeloma and non Hodgkin's lymphoma (human Burkitt's lymphoma). RSC Advances, 4(35), 18007-18016. https://doi.org/10.1039/c3ra45400b

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title = "Gadolinium-loaded polychelating amphiphilic polymer as an enhanced MRI contrast agent for human multiple myeloma and non Hodgkin's lymphoma (human Burkitt's lymphoma)",

abstract = "Liposomes, loaded with gadolinium (Gd) ions using different membrane-incorporated chelating lipids and functionalized with monoclonal anti-CD138 (syndecan-1) antibody were prepared. Nuclear Magnetic Resonance Dispersion (NMRD) analysis showed that use of the polychelating amphiphilic polymer (PAP) increases both the Gd content and the spin-lattice relaxivity of the Gd-loaded-PAP-liposomes as compared to Gd-DTPA-BSA equivalents. The potential application of contrast syndecan-1- and Rituximab-liposomes, for application as a novel minimally invasive diagnostic agent for multiple myeloma and non Hodgkin's lymphoma was investigated.",

author = "Dorota Kozlowska and Swati Biswas and Fox, {Eoin K.} and Bing Wu and Ferdia Bolster and Edupuganti, {Om Prakash} and Vladimir Torchilin and Stephen Eustace and Mauro Botta and Richard O'Kennedy and Brougham, {Dermot F.}",

year = "2014",

doi = "10.1039/c3ra45400b",

language = "English",

volume = "4",

pages = "18007--18016",

journal = "RSC Advances",

issn = "2046-2069",

publisher = "Royal Society of Chemistry",

number = "35",

}

Kozlowska, D, Biswas, S, Fox, EK, Wu, B, Bolster, F, Edupuganti, OP, Torchilin, V, Eustace, S, Botta, M, O'Kennedy, R & Brougham, DF 2014, 'Gadolinium-loaded polychelating amphiphilic polymer as an enhanced MRI contrast agent for human multiple myeloma and non Hodgkin's lymphoma (human Burkitt's lymphoma)', RSC Advances, vol. 4, n. 35, pagg. 18007-18016. https://doi.org/10.1039/c3ra45400b

TY - JOUR

T1 - Gadolinium-loaded polychelating amphiphilic polymer as an enhanced MRI contrast agent for human multiple myeloma and non Hodgkin's lymphoma (human Burkitt's lymphoma)

AU - Kozlowska, Dorota

AU - Biswas, Swati

AU - Fox, Eoin K.

AU - Wu, Bing

AU - Bolster, Ferdia

AU - Edupuganti, Om Prakash

AU - Torchilin, Vladimir

AU - Eustace, Stephen

AU - Botta, Mauro

AU - O'Kennedy, Richard

AU - Brougham, Dermot F.

PY - 2014

Y1 - 2014

N2 - Liposomes, loaded with gadolinium (Gd) ions using different membrane-incorporated chelating lipids and functionalized with monoclonal anti-CD138 (syndecan-1) antibody were prepared. Nuclear Magnetic Resonance Dispersion (NMRD) analysis showed that use of the polychelating amphiphilic polymer (PAP) increases both the Gd content and the spin-lattice relaxivity of the Gd-loaded-PAP-liposomes as compared to Gd-DTPA-BSA equivalents. The potential application of contrast syndecan-1- and Rituximab-liposomes, for application as a novel minimally invasive diagnostic agent for multiple myeloma and non Hodgkin's lymphoma was investigated.

AB - Liposomes, loaded with gadolinium (Gd) ions using different membrane-incorporated chelating lipids and functionalized with monoclonal anti-CD138 (syndecan-1) antibody were prepared. Nuclear Magnetic Resonance Dispersion (NMRD) analysis showed that use of the polychelating amphiphilic polymer (PAP) increases both the Gd content and the spin-lattice relaxivity of the Gd-loaded-PAP-liposomes as compared to Gd-DTPA-BSA equivalents. The potential application of contrast syndecan-1- and Rituximab-liposomes, for application as a novel minimally invasive diagnostic agent for multiple myeloma and non Hodgkin's lymphoma was investigated.

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U2 - 10.1039/c3ra45400b

DO - 10.1039/c3ra45400b

M3 - Article

SN - 2046-2069

VL - 4

SP - 18007

EP - 18016

JO - RSC Advances

JF - RSC Advances

IS - 35

ER -

Gadolinium-loaded polychelating amphiphilic polymer as an enhanced MRI contrast agent for human multiple myeloma and non Hodgkin's lymphoma (human Burkitt's lymphoma)

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