Gadolinium-doped LipoCEST agents: a potential novel class of dual 1H-MRI probes

E TERRENO; C BOFFA; V MENCHISE; F FEDELI; C CARRERA; CASTELLI D DELLI; GIUSEPPE DIGILIO; S. AIME

doi:10.1039/c1cc10172b

Gadolinium-doped LipoCEST agents: a potential novel class of dual 1H-MRI probes

E TERRENO
, C BOFFA
, V MENCHISE
, F FEDELI
, C CARRERA
, CASTELLI D DELLI
, GIUSEPPE DIGILIO
, S. AIME

Dipartimento di Scienze e Innovazione Tecnologica

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

A novel class of paramagnetic liposome-based systems acting as dual T1 and CEST 1H-MRI contrast agents is described. The vesicles contain a shift reagent in the aqueous core and a Gd-complex on the external surface conjugated through a biodegradable linker. As such, the probe can generate T1 contrast only, but after the cleavage and removal of the Gd-coating, the CEST contrast is switched on.

Lingua originale	Inglese
pagine (da-a)	4667-4669
Numero di pagine	3
Rivista	Chemical Communications
Volume	47
DOI	https://doi.org/10.1039/c1cc10172b
Stato di pubblicazione	Pubblicato - 2011

Keywords

Chemical Exchange Saturation Transfer
MRI
PARACEST
gadolinium
liposome
redox responsive
shift reagent

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10.1039/c1cc10172b

http://hdl.handle.net/11579/15643

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@article{1642b4aedeef44eda6cc25596d8e86cb,

title = "Gadolinium-doped LipoCEST agents: a potential novel class of dual 1H-MRI probes",

abstract = "A novel class of paramagnetic liposome-based systems acting as dual T1 and CEST 1H-MRI contrast agents is described. The vesicles contain a shift reagent in the aqueous core and a Gd-complex on the external surface conjugated through a biodegradable linker. As such, the probe can generate T1 contrast only, but after the cleavage and removal of the Gd-coating, the CEST contrast is switched on.",

keywords = "Chemical Exchange Saturation Transfer, MRI, PARACEST, gadolinium, liposome, redox responsive, shift reagent, Chemical Exchange Saturation Transfer, MRI, PARACEST, gadolinium, liposome, redox responsive, shift reagent",

author = "E TERRENO and C BOFFA and V MENCHISE and F FEDELI and C CARRERA and DELLI, \{CASTELLI D\} and GIUSEPPE DIGILIO and S. AIME",

year = "2011",

doi = "10.1039/c1cc10172b",

language = "English",

volume = "47",

pages = "4667--4669",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

}

TY - JOUR

T1 - Gadolinium-doped LipoCEST agents: a potential novel class of dual 1H-MRI probes

AU - TERRENO, E

AU - BOFFA, C

AU - MENCHISE, V

AU - FEDELI, F

AU - CARRERA, C

AU - DELLI, CASTELLI D

AU - DIGILIO, GIUSEPPE

AU - AIME, S.

PY - 2011

Y1 - 2011

N2 - A novel class of paramagnetic liposome-based systems acting as dual T1 and CEST 1H-MRI contrast agents is described. The vesicles contain a shift reagent in the aqueous core and a Gd-complex on the external surface conjugated through a biodegradable linker. As such, the probe can generate T1 contrast only, but after the cleavage and removal of the Gd-coating, the CEST contrast is switched on.

AB - A novel class of paramagnetic liposome-based systems acting as dual T1 and CEST 1H-MRI contrast agents is described. The vesicles contain a shift reagent in the aqueous core and a Gd-complex on the external surface conjugated through a biodegradable linker. As such, the probe can generate T1 contrast only, but after the cleavage and removal of the Gd-coating, the CEST contrast is switched on.

KW - Chemical Exchange Saturation Transfer

KW - MRI

KW - PARACEST

KW - gadolinium

KW - liposome

KW - redox responsive

KW - shift reagent

KW - Chemical Exchange Saturation Transfer

KW - MRI

KW - PARACEST

KW - gadolinium

KW - liposome

KW - redox responsive

KW - shift reagent

UR - https://iris.uniupo.it/handle/11579/15643

U2 - 10.1039/c1cc10172b

DO - 10.1039/c1cc10172b

M3 - Article

SN - 1359-7345

VL - 47

SP - 4667

EP - 4669

JO - Chemical Communications

JF - Chemical Communications

ER -

Gadolinium-doped LipoCEST agents: a potential novel class of dual 1H-MRI probes

Abstract

Keywords

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