Gadolinium-doped LipoCEST agents: A potential novel class of dual 1H-MRI probes

Enzo Terreno; Cinzia Boffa; Valeria Menchise; Franco Fedeli; Carla Carrera; Daniela Delli Castelli; Giuseppe Digilio; Silvio Aime

doi:10.1039/c1cc10172b

Gadolinium-doped LipoCEST agents: A potential novel class of dual ¹H-MRI probes

Enzo Terreno, Cinzia Boffa, Valeria Menchise, Franco Fedeli, Carla Carrera, Daniela Delli Castelli, Giuseppe Digilio, Silvio Aime

Dipartimento di Scienze e Innovazione Tecnologica

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

A novel class of paramagnetic liposome-based systems acting as dual T₁ and CEST ¹H-MRI contrast agents is described. The vesicles contain a shift reagent in the aqueous core and a Gd-complex on the external surface conjugated through a biodegradable linker. As such, the probe can generate T₁ contrast only, but after the cleavage and removal of the Gd-coating, the CEST contrast is switched on.

Lingua originale	Inglese
pagine (da-a)	4667-4669
Numero di pagine	3
Rivista	Chemical Communications
Volume	47
Numero di pubblicazione	16
DOI	https://doi.org/10.1039/c1cc10172b
Stato di pubblicazione	Pubblicato - 4 apr 2011

Accesso al documento

10.1039/c1cc10172b

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abstract = "A novel class of paramagnetic liposome-based systems acting as dual T1 and CEST 1H-MRI contrast agents is described. The vesicles contain a shift reagent in the aqueous core and a Gd-complex on the external surface conjugated through a biodegradable linker. As such, the probe can generate T1 contrast only, but after the cleavage and removal of the Gd-coating, the CEST contrast is switched on.",

author = "Enzo Terreno and Cinzia Boffa and Valeria Menchise and Franco Fedeli and Carla Carrera and Castelli, {Daniela Delli} and Giuseppe Digilio and Silvio Aime",

year = "2011",

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AU - Fedeli, Franco

AU - Carrera, Carla

AU - Castelli, Daniela Delli

AU - Digilio, Giuseppe

AU - Aime, Silvio

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AB - A novel class of paramagnetic liposome-based systems acting as dual T1 and CEST 1H-MRI contrast agents is described. The vesicles contain a shift reagent in the aqueous core and a Gd-complex on the external surface conjugated through a biodegradable linker. As such, the probe can generate T1 contrast only, but after the cleavage and removal of the Gd-coating, the CEST contrast is switched on.

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