Gadolinium-Decorated Silica Microspheres as Redox-Responsive MRI Probes for Applications in Cell Therapy Follow-Up

Monica Muñoz Úbeda; Fabio Carniato; Valeria Catanzaro; Sergio Padovan; Cristina Grange; Stefano Porta; Carla Carrera; Lorenzo Tei; Giuseppe Digilio

doi:10.1002/chem.201600962

Gadolinium-Decorated Silica Microspheres as Redox-Responsive MRI Probes for Applications in Cell Therapy Follow-Up

Monica Muñoz Úbeda, Fabio Carniato, Valeria Catanzaro, Sergio Padovan, Cristina Grange, Stefano Porta, Carla Carrera, Lorenzo Tei, Giuseppe Digilio

Dipartimento di Scienze e Innovazione Tecnologica

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

The redox microenvironment within a cell graft can be considered as an indicator to assess whether the graft is metabolically active or hypoxic. We present a redox-responsive MRI probe based on porous silica microparticles whose surface has been decorated with a Gd-chelate through a disulphide bridge. Such microparticles are designed to be interspersed with therapeutic cells within a biocompatible hydrogel. The onset of reducing conditions within the hydrogel is paralleled by an increased clearance of Gd, that can be detected by MRI.

Lingua originale	Inglese
pagine (da-a)	7716-7720
Numero di pagine	5
Rivista	Chemistry - A European Journal
Volume	22
Numero di pubblicazione	23
DOI	https://doi.org/10.1002/chem.201600962
Stato di pubblicazione	Pubblicato - 1 giu 2016

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10.1002/chem.201600962

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title = "Gadolinium-Decorated Silica Microspheres as Redox-Responsive MRI Probes for Applications in Cell Therapy Follow-Up",

abstract = "The redox microenvironment within a cell graft can be considered as an indicator to assess whether the graft is metabolically active or hypoxic. We present a redox-responsive MRI probe based on porous silica microparticles whose surface has been decorated with a Gd-chelate through a disulphide bridge. Such microparticles are designed to be interspersed with therapeutic cells within a biocompatible hydrogel. The onset of reducing conditions within the hydrogel is paralleled by an increased clearance of Gd, that can be detected by MRI.",

keywords = "cellular imaging, gadolinium, magnetic resonance imaging, redox-responsive, silica microspheres",

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AU - Muñoz Úbeda, Monica

AU - Carniato, Fabio

AU - Catanzaro, Valeria

AU - Padovan, Sergio

AU - Grange, Cristina

AU - Porta, Stefano

AU - Carrera, Carla

AU - Tei, Lorenzo

AU - Digilio, Giuseppe

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AB - The redox microenvironment within a cell graft can be considered as an indicator to assess whether the graft is metabolically active or hypoxic. We present a redox-responsive MRI probe based on porous silica microparticles whose surface has been decorated with a Gd-chelate through a disulphide bridge. Such microparticles are designed to be interspersed with therapeutic cells within a biocompatible hydrogel. The onset of reducing conditions within the hydrogel is paralleled by an increased clearance of Gd, that can be detected by MRI.

KW - cellular imaging

KW - gadolinium

KW - magnetic resonance imaging

KW - redox-responsive

KW - silica microspheres

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JO - Chemistry - A European Journal

JF - Chemistry - A European Journal

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ER -

Gadolinium-Decorated Silica Microspheres as Redox-Responsive MRI Probes for Applications in Cell Therapy Follow-Up

Abstract

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