Fused tricyclic mGluR1 antagonists for the treatment of neuropathic pain

Chad E. Bennett, Duane A. Burnett, William J. Greenlee, Chad E. Knutson, Peter Korakas, Cheng Li, Deen Tulshian, Wen Lian Wu, Rosalia Bertorelli, Silva Fredduzzi, Mariagrazia Grilli, Gianluca Lozza, Angelo Reggiani, Alessio Veltri

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

A series of fused tricyclic mGluR1 antagonists containing a pyridone ring were synthesized. In vitro, these antagonists were potent against both human and rat isozymes, as well as selective for inhibiting mGluR1 over mGluR5. When dosed orally, several examples were active in vivo in a rat SNL test.

Lingua originaleInglese
pagine (da-a)1575-1578
Numero di pagine4
RivistaBioorganic and Medicinal Chemistry Letters
Volume22
Numero di pubblicazione4
DOI
Stato di pubblicazionePubblicato - 15 feb 2012
Pubblicato esternamente

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