@article{85100bfb57254991a63e714fd56b2d6f,
title = "Fused tricyclic mGluR1 antagonists for the treatment of neuropathic pain",
abstract = "A series of fused tricyclic mGluR1 antagonists containing a pyridone ring were synthesized. In vitro, these antagonists were potent against both human and rat isozymes, as well as selective for inhibiting mGluR1 over mGluR5. When dosed orally, several examples were active in vivo in a rat SNL test.",
keywords = "Fused tricyclic pyridones, GPCR, MGluR1 (metabotropic glutamate receptor 1), Neuropathic pain, Spinal nerve ligation (SNL)",
author = "Bennett, {Chad E.} and Burnett, {Duane A.} and Greenlee, {William J.} and Knutson, {Chad E.} and Peter Korakas and Cheng Li and Deen Tulshian and Wu, {Wen Lian} and Rosalia Bertorelli and Silva Fredduzzi and Mariagrazia Grilli and Gianluca Lozza and Angelo Reggiani and Alessio Veltri",
year = "2012",
month = feb,
day = "15",
doi = "10.1016/j.bmcl.2011.12.131",
language = "English",
volume = "22",
pages = "1575--1578",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Ltd.",
number = "4",
}