Functionalized thymidine derivatives as carriers for the γ-emitter technetium tricarbonyl moiety

Roger Alberto, Harmel P. N'Dongo, Marco Clericuzio, Samuele Bonetti, Elisabetta Gabano, Claudio Cassino, Mauro Ravera, Domenico Osella

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

Nuclear medicine imaging of cell proliferation has gained broad interest in clinical oncology. A good tracer to image cell proliferation, possibly associated to tumour progression, should rapidly and specifically be incorporated into growing DNA. Following this idea, we have singled out thymidine as a potential biological carrier for delivery of the organometallic fragment [M(CO)3]+ (M = "cold" Re, γ-emitter 99mTc) to DNA. In the present paper we report the two-step synthesis of thymidine N-3 derivatives and their coordination complexes. Thymidine could be alkylated without protecting the sugar alcoholic functions. Methyl-2,2′-diaminodiethylamine thymidine derivative was quickly reacted with rhenium and technetium carbonyls in almost quantitative yield. The resulting 99mTc complex represents a convenient radiopharmaceutical for single photon emission tomography (SPECT).

Lingua originaleInglese
pagine (da-a)4785-4790
Numero di pagine6
RivistaInorganica Chimica Acta
Volume362
Numero di pubblicazione13
DOI
Stato di pubblicazionePubblicato - 15 ott 2009

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