Abstract
Nuclear medicine imaging of cell proliferation has gained broad interest in clinical oncology. A good tracer to image cell proliferation, possibly associated to tumour progression, should rapidly and specifically be incorporated into growing DNA. Following this idea, we have singled out thymidine as a potential biological carrier for delivery of the organometallic fragment [M(CO)3]+ (M = "cold" Re, γ-emitter 99mTc) to DNA. In the present paper we report the two-step synthesis of thymidine N-3 derivatives and their coordination complexes. Thymidine could be alkylated without protecting the sugar alcoholic functions. Methyl-2,2′-diaminodiethylamine thymidine derivative was quickly reacted with rhenium and technetium carbonyls in almost quantitative yield. The resulting 99mTc complex represents a convenient radiopharmaceutical for single photon emission tomography (SPECT).
Lingua originale | Inglese |
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pagine (da-a) | 4785-4790 |
Numero di pagine | 6 |
Rivista | Inorganica Chimica Acta |
Volume | 362 |
Numero di pubblicazione | 13 |
DOI | |
Stato di pubblicazione | Pubblicato - 15 ott 2009 |