Functionalization of β-caryophyllene generates novel polypharmacology in the endocannabinoid system

Keyphrases

• Caryophyllene 100%
• Endocannabinoid System 100%
• Sesquiterpene Hydrocarbons 100%
• Polypharmacology 100%
• Functional Groups 66%
• Double Bond 66%
• Fatty Acid Amide Hydrolase 66%
• Endocannabinoids 66%
• CB2 Receptor 66%
• Monocyclic 66%
• Binding Site 33%
• Analgesic Effect 33%
• Amides 33%
• Pharmacophore 33%
• Monoacylglycerol Lipase 33%
• New Scaffolds 33%
• Structural Insights 33%
• Hydrocarbons 33%
• Promiscuity 33%
• Medium-sized Rings 33%
• Agonism 33%
• Dual Inhibitor 33%
• Amide Functionalization 33%
• Ethyl Acrylate 33%
• Anti-inflammatory Effect 33%
• Constraint Induced 33%
• Effective Compounds 33%
• Ring-opening Cross Metathesis 33%
• Functional Repertoire 33%
• Cyclooxygenase-2 33%
• CB2 Cannabinoid Receptor 33%
• Pharmacological Profile 33%
• Well-defined 33%
• Cannabimimetics 33%
• Conformational Constraint 33%
• Dietary Plants 33%
• Degradative Enzymes 33%
• Structure-activity Studies 33%
• Hydrolases 33%

Pharmacology, Toxicology and Pharmaceutical Science

• Sesquiterpene 100%
• Caryophyllene 100%
• Endocannabinoid System 100%
• Functional Groups 66%
• Double Bond 66%
• Carboxamide 66%
• Fatty Acid Amidase 66%
• Endocannabinoid 66%
• Cannabinoid 2 Receptor 66%
• Receptor 33%
• Analgesic Agent 33%
• Acylglycerol Lipase 33%
• Ethyl Acrylate 33%
• Anti-Inflammatory Drug 33%
• Hydrolase 33%
• Binding Site 33%
• Boron 33%
• Carbon 11 33%
• Cyclooxygenase 2 33%

Biochemistry, Genetics and Molecular Biology

• Fatty Acid Amide Hydrolase 100%
• Endocannabinoid System 100%
• Caryophyllene 100%
• Enzyme 50%
• Agonist 50%
• Binding Site 50%
• Monoacylglycerol Lipase 50%
• Pharmacophore 50%
• Ethyl Acrylate 50%
• Cyclooxygenase 50%
• Hydrolase 50%
• Analgesic Activity 50%
• Cannabinoid Receptor 50%
• Antiinflammatory Activity 50%
• Ring Opening 50%