TY - JOUR
T1 - From MASLD to HCC: What's in the middle?
AU - Provera, Alessia
AU - Vecchio, Cristina
AU - Sheferaw, Anteneh Nigussie
AU - Stoppa, Ian
AU - Pantham, Deepika
AU - DIANZANI, Umberto
AU - SUTTI, Salvatore
PY - 2024
Y1 - 2024
N2 - Metabolic dysfunction associated steatotic liver disease (MASLD) is a progressive pathological condition characterized by the accumulation of triglycerides within hepatocytes that causes histological changes, which, in the long run, might compromise liver functional capacities. MASLD predisposes to metabolic dysfunction-associated steatohepatitis (MASH), in which the persistence of inflammatory reactions perpetuates tissue injury and induces alterations of the extracellular matrix, leading to liver fibrosis and cirrhosis. Furthermore, these processes are also fertile ground for the development of hepatocellular carcinoma (HCC). In this latter respect, growing evidence suggests that chronic inflammation not only acts as the primary stimulus for hepatocellular malignant transformation, cell proliferation and cancer cell progression but also reshapes the immune landscape, inducing immune system exhaustion and favoring the loss of cancer immune surveillance. Therefore, a thorough understanding of the cellular and molecular mechanisms orchestrating hepatic inflammatory responses may open the way for fine-tuning therapeutic interventions that could, from one side, counteract MASLD progression and, on the other one, effectively treat HCCs.
AB - Metabolic dysfunction associated steatotic liver disease (MASLD) is a progressive pathological condition characterized by the accumulation of triglycerides within hepatocytes that causes histological changes, which, in the long run, might compromise liver functional capacities. MASLD predisposes to metabolic dysfunction-associated steatohepatitis (MASH), in which the persistence of inflammatory reactions perpetuates tissue injury and induces alterations of the extracellular matrix, leading to liver fibrosis and cirrhosis. Furthermore, these processes are also fertile ground for the development of hepatocellular carcinoma (HCC). In this latter respect, growing evidence suggests that chronic inflammation not only acts as the primary stimulus for hepatocellular malignant transformation, cell proliferation and cancer cell progression but also reshapes the immune landscape, inducing immune system exhaustion and favoring the loss of cancer immune surveillance. Therefore, a thorough understanding of the cellular and molecular mechanisms orchestrating hepatic inflammatory responses may open the way for fine-tuning therapeutic interventions that could, from one side, counteract MASLD progression and, on the other one, effectively treat HCCs.
KW - Chronic inflammation
KW - HCC
KW - Immunity
KW - Immunotherapies
KW - MASH
KW - MASLD
KW - Chronic inflammation
KW - HCC
KW - Immunity
KW - Immunotherapies
KW - MASH
KW - MASLD
UR - https://iris.uniupo.it/handle/11579/189262
U2 - 10.1016/j.heliyon.2024.e35338
DO - 10.1016/j.heliyon.2024.e35338
M3 - Article
SN - 2405-8440
VL - 10
JO - Heliyon
JF - Heliyon
IS - 15
ER -