TY - JOUR
T1 - From bone marrow to the arterial wall
T2 - The ongoing tale of endothelial progenitor cells
AU - Leone, Antonio Maria
AU - Valgimigli, Marco
AU - Giannico, Maria Benedetta
AU - Zaccone, Vincenzo
AU - Perfetti, Matteo
AU - D'Amario, Domenico
AU - Rebuzzi, Antonio Giuseppe
AU - Crea, Filippo
N1 - Funding Information:
This study was supported by a grant from the Fondazione Cassa di Ris-parmio di Roma to UNICATT Cord Blood Bank of the Catholic University of the Sacred Heart of Rome.
PY - 2009/4
Y1 - 2009/4
N2 - Several physiological and pathophysiological stimuli or drugs modulate endothelial progenitor cell (EPC) mobilization. Moreover, levels of circulating EPCs predict cardiovascular risk and left ventricular remodelling after myocardial infarction. Nevertheless, our understanding in this field is complicated by lack of an unequivocal definition of EPCs, thus limiting their clinical applications. This review summarizes current knowledge and uncertainties on EPC characterization and mobilization in the attempt to define their role in the management of cardiovascular diseases.
AB - Several physiological and pathophysiological stimuli or drugs modulate endothelial progenitor cell (EPC) mobilization. Moreover, levels of circulating EPCs predict cardiovascular risk and left ventricular remodelling after myocardial infarction. Nevertheless, our understanding in this field is complicated by lack of an unequivocal definition of EPCs, thus limiting their clinical applications. This review summarizes current knowledge and uncertainties on EPC characterization and mobilization in the attempt to define their role in the management of cardiovascular diseases.
KW - Acute myocardial infarction
KW - Bone marrow-derived stem cells
KW - Endothelial progenitor cells
KW - Stem cell mobilization
UR - http://www.scopus.com/inward/record.url?scp=65249187239&partnerID=8YFLogxK
U2 - 10.1093/eurheartj/ehp078
DO - 10.1093/eurheartj/ehp078
M3 - Review article
SN - 0195-668X
VL - 30
SP - 890
EP - 899
JO - European Heart Journal
JF - European Heart Journal
IS - 8
ER -
