Frequent aberrant promoter hypermethylation of O6-methylguanine- DNA methyltransferase and death-associated protein kinase genes in immunodeficiency-related lymphomas

Davide Rossi; Gianluca Gaidano; Annunziata Gloghini; Clara Deambrogi; Silvia Franceschetti; Eva Berra; Michaela Cerri; Chiara Vendramin; Annarita Conconi; Alessandra Viglio; Giuliana Muti; Pierluigi Oreste; Enrica Morra; Marco Paulli; Daniela Capello; Antonino Carbone

doi:10.1046/j.1365-2141.2003.04644.x

Frequent aberrant promoter hypermethylation of O⁶-methylguanine- DNA methyltransferase and death-associated protein kinase genes in immunodeficiency-related lymphomas

Davide Rossi, Gianluca Gaidano, Annunziata Gloghini, Clara Deambrogi, Silvia Franceschetti, Eva Berra, Michaela Cerri, Chiara Vendramin, Annarita Conconi, Alessandra Viglio, Giuliana Muti, Pierluigi Oreste, Enrica Morra, Marco Paulli, Daniela Capello, Antonino Carbone

Dipartimento di Medicina Traslazionale

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Aberrant promoter hypermethylation is a mechanism of tumour suppressor gene inactivation. We explored aberrant promoter hypermethylation of multiple genes in 88 human immunodeficiency virus (HIV)-non Hodgkin lymphomas (NHL). 25 post-transplant lymphoproliferative disorders (PTLD) and five common variable immunodeficiency (CVI)-related NHL. Twenty-six of 79 (32.9%) HIV-NHL, eight of 14 (57.1%) PTLD and two of five (40.0%) CVI-NHL showed aberrant hypermethylation of O⁶-methylguanine-DNA methyltransferase (MGMT). Aberrant hypermethylation of death-associated protein-kinase (DAP-K) occurred in 70 of 84 (83.3%) HIV-NHL, 19 of 25 (72.0%) PTLD and three of five (60.0%) CVI-NHL. These data implicate MGMT and DAP-K hypermethylation in lymphomagenesis of immunodeficient hosts. In particular, promoter hypermethylation of DAP-K represents the most frequent molecular alteration yet identified in immunodeficiency-related lymphomas.

Lingua originale	Inglese
pagine (da-a)	475-478
Numero di pagine	4
Rivista	British Journal of Haematology
Volume	123
Numero di pubblicazione	3
DOI	https://doi.org/10.1046/j.1365-2141.2003.04644.x
Stato di pubblicazione	Pubblicato - nov 2003

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10.1046/j.1365-2141.2003.04644.x

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Cita questo

Rossi, D., Gaidano, G., Gloghini, A., Deambrogi, C., Franceschetti, S., Berra, E., Cerri, M., Vendramin, C., Conconi, A., Viglio, A., Muti, G., Oreste, P., Morra, E., Paulli, M., Capello, D., & Carbone, A. (2003). Frequent aberrant promoter hypermethylation of O⁶-methylguanine- DNA methyltransferase and death-associated protein kinase genes in immunodeficiency-related lymphomas. British Journal of Haematology, 123(3), 475-478. https://doi.org/10.1046/j.1365-2141.2003.04644.x

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abstract = "Aberrant promoter hypermethylation is a mechanism of tumour suppressor gene inactivation. We explored aberrant promoter hypermethylation of multiple genes in 88 human immunodeficiency virus (HIV)-non Hodgkin lymphomas (NHL). 25 post-transplant lymphoproliferative disorders (PTLD) and five common variable immunodeficiency (CVI)-related NHL. Twenty-six of 79 (32.9%) HIV-NHL, eight of 14 (57.1%) PTLD and two of five (40.0%) CVI-NHL showed aberrant hypermethylation of O6-methylguanine-DNA methyltransferase (MGMT). Aberrant hypermethylation of death-associated protein-kinase (DAP-K) occurred in 70 of 84 (83.3%) HIV-NHL, 19 of 25 (72.0%) PTLD and three of five (60.0%) CVI-NHL. These data implicate MGMT and DAP-K hypermethylation in lymphomagenesis of immunodeficient hosts. In particular, promoter hypermethylation of DAP-K represents the most frequent molecular alteration yet identified in immunodeficiency-related lymphomas.",

keywords = "DNA methylation, Death associated protein-kinase, Immunodeficiency, Lymphoma, O-methylguanine-DNA methyltransferase",

author = "Davide Rossi and Gianluca Gaidano and Annunziata Gloghini and Clara Deambrogi and Silvia Franceschetti and Eva Berra and Michaela Cerri and Chiara Vendramin and Annarita Conconi and Alessandra Viglio and Giuliana Muti and Pierluigi Oreste and Enrica Morra and Marco Paulli and Daniela Capello and Antonino Carbone",

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month = nov,

doi = "10.1046/j.1365-2141.2003.04644.x",

language = "English",

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Rossi, D, Gaidano, G, Gloghini, A, Deambrogi, C, Franceschetti, S, Berra, E, Cerri, M, Vendramin, C, Conconi, A, Viglio, A, Muti, G, Oreste, P, Morra, E, Paulli, M, Capello, D & Carbone, A 2003, 'Frequent aberrant promoter hypermethylation of O⁶-methylguanine- DNA methyltransferase and death-associated protein kinase genes in immunodeficiency-related lymphomas', British Journal of Haematology, vol. 123, n. 3, pagg. 475-478. https://doi.org/10.1046/j.1365-2141.2003.04644.x

Frequent aberrant promoter hypermethylation of O⁶-methylguanine- DNA methyltransferase and death-associated protein kinase genes in immunodeficiency-related lymphomas. / Rossi, Davide; Gaidano, Gianluca; Gloghini, Annunziata et al.
In: British Journal of Haematology, Vol. 123, N. 3, 11.2003, pag. 475-478.

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

TY - JOUR

T1 - Frequent aberrant promoter hypermethylation of O6-methylguanine- DNA methyltransferase and death-associated protein kinase genes in immunodeficiency-related lymphomas

AU - Rossi, Davide

AU - Gaidano, Gianluca

AU - Gloghini, Annunziata

AU - Deambrogi, Clara

AU - Franceschetti, Silvia

AU - Berra, Eva

AU - Cerri, Michaela

AU - Vendramin, Chiara

AU - Conconi, Annarita

AU - Viglio, Alessandra

AU - Muti, Giuliana

AU - Oreste, Pierluigi

AU - Morra, Enrica

AU - Paulli, Marco

AU - Capello, Daniela

AU - Carbone, Antonino

PY - 2003/11

Y1 - 2003/11

N2 - Aberrant promoter hypermethylation is a mechanism of tumour suppressor gene inactivation. We explored aberrant promoter hypermethylation of multiple genes in 88 human immunodeficiency virus (HIV)-non Hodgkin lymphomas (NHL). 25 post-transplant lymphoproliferative disorders (PTLD) and five common variable immunodeficiency (CVI)-related NHL. Twenty-six of 79 (32.9%) HIV-NHL, eight of 14 (57.1%) PTLD and two of five (40.0%) CVI-NHL showed aberrant hypermethylation of O6-methylguanine-DNA methyltransferase (MGMT). Aberrant hypermethylation of death-associated protein-kinase (DAP-K) occurred in 70 of 84 (83.3%) HIV-NHL, 19 of 25 (72.0%) PTLD and three of five (60.0%) CVI-NHL. These data implicate MGMT and DAP-K hypermethylation in lymphomagenesis of immunodeficient hosts. In particular, promoter hypermethylation of DAP-K represents the most frequent molecular alteration yet identified in immunodeficiency-related lymphomas.

AB - Aberrant promoter hypermethylation is a mechanism of tumour suppressor gene inactivation. We explored aberrant promoter hypermethylation of multiple genes in 88 human immunodeficiency virus (HIV)-non Hodgkin lymphomas (NHL). 25 post-transplant lymphoproliferative disorders (PTLD) and five common variable immunodeficiency (CVI)-related NHL. Twenty-six of 79 (32.9%) HIV-NHL, eight of 14 (57.1%) PTLD and two of five (40.0%) CVI-NHL showed aberrant hypermethylation of O6-methylguanine-DNA methyltransferase (MGMT). Aberrant hypermethylation of death-associated protein-kinase (DAP-K) occurred in 70 of 84 (83.3%) HIV-NHL, 19 of 25 (72.0%) PTLD and three of five (60.0%) CVI-NHL. These data implicate MGMT and DAP-K hypermethylation in lymphomagenesis of immunodeficient hosts. In particular, promoter hypermethylation of DAP-K represents the most frequent molecular alteration yet identified in immunodeficiency-related lymphomas.

KW - DNA methylation

KW - Death associated protein-kinase

KW - Immunodeficiency

KW - Lymphoma

KW - O-methylguanine-DNA methyltransferase

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U2 - 10.1046/j.1365-2141.2003.04644.x

DO - 10.1046/j.1365-2141.2003.04644.x

M3 - Article

SN - 0007-1048

VL - 123

SP - 475

EP - 478

JO - British Journal of Haematology

JF - British Journal of Haematology

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