@inproceedings{a320b0f97fa14aedac34df7e36a8ea91,
title = "Free radical mechanisms in alcohol-mediated liver injury",
abstract = "Experimental and clinical studies indicate that oxidative damage occurs in the liver during either acute or chronic alcoholic intoxication. Nonetheless, the mechanisms responsible for the pro-oxidant action of ethanol and their relevance in the pathogenesis of the hepatic lesions are still largely unknown. The observation that ethanol, as well as other alcohols, is activated to a free radical intermediate by the action of the ethanol-inducible form of cytochrome P-450 has given new insight into the problem. Besides the formation of ethanol radicals there is evidence that reactive oxygen species such as superoxide anion and hydrogen peroxide can also be generated by the activity of the microsomal monooxygenase system and during the oxidation of acetaldehyde by xanthine oxidase. It is possible that the various mechanisms of free radical formation contribute to different extents in causing the oxidative lesions seen in the presence of acute or chronic intoxication.",
author = "E. Albano and G. Poli and A. Tomasi and Dianzani, \{M. U.\}",
year = "1990",
language = "English",
isbn = "0444812113",
series = "Chronic liver damage: proceedings of the Annual Meeting of the Italian National Programme on Liver Cirrhosis. ICS910",
publisher = "Elsevier Science Publishers B. V.",
pages = "27--37",
editor = "M.U. Dianzani and P. Gentilini and M.U. Dianzani and P. Gentilini",
booktitle = "Chronic liver damage",
note = "The Annual Meeting of the Italian National Programme on Liver Cirrhosis ; Conference date: 11-01-1990 Through 13-01-1990",
}