Formosulfathiazole: A Structural Revision

Claudio Maestri; Toni Grell; Fabio Travagin; Christian R. Göb; Michele Castaldi; Ivana Miletto; Geo Paul; Silvia Zampini; Marco Vandone; Valentina Colombo; Giovanni B. Giovenzana

doi:10.1002/cplu.202500406

Formosulfathiazole: A Structural Revision

Claudio Maestri
, Toni Grell
, Fabio Travagin
, Christian R. Göb
, Michele Castaldi
, Ivana Miletto
, Geo Paul
, Silvia Zampini
, Marco Vandone
, Valentina Colombo
, Giovanni B. Giovenzana

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Formosulfathiazole (FSTz) is a synthetic active pharmaceutical ingredient (API) prepared by condensation of sulfathiazole with formaldehyde. Originally described for the first time in 1948, it is currently used for the treatment of bacterial and protozoal infections in cattle and pets, acting as a prodrug slowly releasing the sulfamidic sulfathiazole and formaldehyde. A systematic analysis of FSTz allowed to revise the originally believed undefined polymeric structure and uncovered the intriguing cyclophane skeleton of a well-defined cyclodimeric condensation product.

Lingua originale	Inglese
Numero di articolo	e202500406
Rivista	ChemPlusChem
Volume	90
Numero di pubblicazione	11
DOI	https://doi.org/10.1002/cplu.202500406
Stato di pubblicazione	Pubblicato - 10 nov 2025

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10.1002/cplu.202500406

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title = "Formosulfathiazole: A Structural Revision",

abstract = "Formosulfathiazole (FSTz) is a synthetic active pharmaceutical ingredient (API) prepared by condensation of sulfathiazole with formaldehyde. Originally described for the first time in 1948, it is currently used for the treatment of bacterial and protozoal infections in cattle and pets, acting as a prodrug slowly releasing the sulfamidic sulfathiazole and formaldehyde. A systematic analysis of FSTz allowed to revise the originally believed undefined polymeric structure and uncovered the intriguing cyclophane skeleton of a well-defined cyclodimeric condensation product.",

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T2 - A Structural Revision

AU - Maestri, Claudio

AU - Grell, Toni

AU - Travagin, Fabio

AU - Göb, Christian R.

AU - Castaldi, Michele

AU - Miletto, Ivana

AU - Paul, Geo

AU - Zampini, Silvia

AU - Vandone, Marco

AU - Colombo, Valentina

AU - Giovenzana, Giovanni B.

PY - 2025/11/10

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N2 - Formosulfathiazole (FSTz) is a synthetic active pharmaceutical ingredient (API) prepared by condensation of sulfathiazole with formaldehyde. Originally described for the first time in 1948, it is currently used for the treatment of bacterial and protozoal infections in cattle and pets, acting as a prodrug slowly releasing the sulfamidic sulfathiazole and formaldehyde. A systematic analysis of FSTz allowed to revise the originally believed undefined polymeric structure and uncovered the intriguing cyclophane skeleton of a well-defined cyclodimeric condensation product.

AB - Formosulfathiazole (FSTz) is a synthetic active pharmaceutical ingredient (API) prepared by condensation of sulfathiazole with formaldehyde. Originally described for the first time in 1948, it is currently used for the treatment of bacterial and protozoal infections in cattle and pets, acting as a prodrug slowly releasing the sulfamidic sulfathiazole and formaldehyde. A systematic analysis of FSTz allowed to revise the originally believed undefined polymeric structure and uncovered the intriguing cyclophane skeleton of a well-defined cyclodimeric condensation product.

KW - cyclodimer

KW - cyclophane

KW - electron diffraction

KW - formosulfathiazole

KW - structural revision

UR - https://www.scopus.com/pages/publications/105015353417

U2 - 10.1002/cplu.202500406

DO - 10.1002/cplu.202500406

M3 - Article

SN - 2192-6506

VL - 90

JO - ChemPlusChem

JF - ChemPlusChem

IS - 11

M1 - e202500406

ER -

Formosulfathiazole: A Structural Revision

Abstract

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