Forensic mitochondrial DNA analysis in HIV-infected patients treated with nucleoside reverse transcriptase inhibitors

C. ROBINO; C. COLLA; A. BIGLINO; M. DEGIOANNI; Sarah GINO; C. TORRE

Forensic mitochondrial DNA analysis in HIV-infected patients treated with nucleoside reverse transcriptase inhibitors

C. ROBINO, C. COLLA, A. BIGLINO, M. DEGIOANNI, Sarah GINO, C. TORRE

Dipartimento di Scienze della Salute

Risultato della ricerca: Contributo alla conferenza › Contributo in Atti di Convegno

Abstract

Hypervariable regions HV1 and HV2 of the mitochondrial DNA control region were sequenced in pre-therapy (serum) and post-therapy (saliva, hair) biological samples collected from HIV-infected patients (n = 13) treated with nucleoside reverse transcriptase inhibitors (NRTIs). Occurrence of length/point heteroplasmic mutations as a consequence of treatment with NRTIs was evaluated. The observed rate of length heteroplasmy in the analyzed samples was consistent with values previously reported in untreated subjects, whereas no evidence of point heteroplasmy in post-treatment tissue samples was seen.

Lingua originale	Inglese
Pagine	501-502
Numero di pagine	2
Stato di pubblicazione	Pubblicato - 1 gen 2009
Evento	23rd International ISFG Congress - Buenos Aires Durata: 1 gen 2009 → …

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???event.eventtypes.event.conference???	23rd International ISFG Congress
Città	Buenos Aires
Periodo	1/01/09 → …

Keywords

Mitochondrial DNA
Control region
Reverse transcriptase inhibitors
HIV
Hair

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title = "Forensic mitochondrial DNA analysis in HIV-infected patients treated with nucleoside reverse transcriptase inhibitors",

abstract = "Hypervariable regions HV1 and HV2 of the mitochondrial DNA control region were sequenced in pre-therapy (serum) and post-therapy (saliva, hair) biological samples collected from HIV-infected patients (n = 13) treated with nucleoside reverse transcriptase inhibitors (NRTIs). Occurrence of length/point heteroplasmic mutations as a consequence of treatment with NRTIs was evaluated. The observed rate of length heteroplasmy in the analyzed samples was consistent with values previously reported in untreated subjects, whereas no evidence of point heteroplasmy in post-treatment tissue samples was seen.",

keywords = "Mitochondrial DNA, Control region, Reverse transcriptase inhibitors, HIV, Hair, Mitochondrial DNA, Control region, Reverse transcriptase inhibitors, HIV, Hair",

author = "C. ROBINO and C. COLLA and A. BIGLINO and M. DEGIOANNI and Sarah GINO and C. TORRE",

year = "2009",

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TY - CONF

T1 - Forensic mitochondrial DNA analysis in HIV-infected patients treated with nucleoside reverse transcriptase inhibitors

AU - ROBINO, C.

AU - COLLA, C.

AU - BIGLINO, A.

AU - DEGIOANNI, M.

AU - GINO, Sarah

AU - TORRE, C.

PY - 2009/1/1

Y1 - 2009/1/1

N2 - Hypervariable regions HV1 and HV2 of the mitochondrial DNA control region were sequenced in pre-therapy (serum) and post-therapy (saliva, hair) biological samples collected from HIV-infected patients (n = 13) treated with nucleoside reverse transcriptase inhibitors (NRTIs). Occurrence of length/point heteroplasmic mutations as a consequence of treatment with NRTIs was evaluated. The observed rate of length heteroplasmy in the analyzed samples was consistent with values previously reported in untreated subjects, whereas no evidence of point heteroplasmy in post-treatment tissue samples was seen.

AB - Hypervariable regions HV1 and HV2 of the mitochondrial DNA control region were sequenced in pre-therapy (serum) and post-therapy (saliva, hair) biological samples collected from HIV-infected patients (n = 13) treated with nucleoside reverse transcriptase inhibitors (NRTIs). Occurrence of length/point heteroplasmic mutations as a consequence of treatment with NRTIs was evaluated. The observed rate of length heteroplasmy in the analyzed samples was consistent with values previously reported in untreated subjects, whereas no evidence of point heteroplasmy in post-treatment tissue samples was seen.

KW - Mitochondrial DNA

KW - Control region

KW - Reverse transcriptase inhibitors

KW - HIV

KW - Hair

KW - Mitochondrial DNA

KW - Control region

KW - Reverse transcriptase inhibitors

KW - HIV

KW - Hair

UR - https://iris.uniupo.it/handle/11579/100071

M3 - Paper

SP - 501

EP - 502

T2 - 23rd International ISFG Congress

Y2 - 1 January 2009

ER -

Forensic mitochondrial DNA analysis in HIV-infected patients treated with nucleoside reverse transcriptase inhibitors

Abstract

???event.eventtypes.event.conference???

Keywords

OSS delle Nazioni Unite

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