Forensic mitochondrial DNA analysis in HIV-infected patients treated with nucleoside reverse transcriptase inhibitors

C. Robino; C. Colla; A. Biglino; M. Degioanni; S. Gino; C. Torre

doi:10.1016/j.fsigss.2009.08.023

Forensic mitochondrial DNA analysis in HIV-infected patients treated with nucleoside reverse transcriptase inhibitors

C. Robino, C. Colla, A. Biglino, M. Degioanni, S. Gino, C. Torre

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Hypervariable regions HV1 and HV2 of the mitochondrial DNA control region were sequenced in pre-therapy (serum) and post-therapy (saliva, hair) biological samples collected from HIV-infected patients (n = 13) treated with nucleoside reverse transcriptase inhibitors (NRTIs). Occurrence of length/point heteroplasmic mutations as a consequence of treatment with NRTIs was evaluated. The observed rate of length heteroplasmy in the analyzed samples was consistent with values previously reported in untreated subjects, whereas no evidence of point heteroplasmy in post-treatment tissue samples was seen.

Lingua originale	Inglese
pagine (da-a)	501-502
Numero di pagine	2
Rivista	Forensic Science International: Genetics Supplement Series
Volume	2
Numero di pubblicazione	1
DOI	https://doi.org/10.1016/j.fsigss.2009.08.023
Stato di pubblicazione	Pubblicato - gen 2009
Pubblicato esternamente	Sì

OSS delle Nazioni Unite

Questo processo contribuisce al raggiungimento dei seguenti obiettivi di sviluppo sostenibile

Accesso al documento

10.1016/j.fsigss.2009.08.023

Altri file e collegamenti

Link to publication in Scopus

Cita questo

@article{7bb200cc9e2e4066b33664cf66593039,

title = "Forensic mitochondrial DNA analysis in HIV-infected patients treated with nucleoside reverse transcriptase inhibitors",

abstract = "Hypervariable regions HV1 and HV2 of the mitochondrial DNA control region were sequenced in pre-therapy (serum) and post-therapy (saliva, hair) biological samples collected from HIV-infected patients (n = 13) treated with nucleoside reverse transcriptase inhibitors (NRTIs). Occurrence of length/point heteroplasmic mutations as a consequence of treatment with NRTIs was evaluated. The observed rate of length heteroplasmy in the analyzed samples was consistent with values previously reported in untreated subjects, whereas no evidence of point heteroplasmy in post-treatment tissue samples was seen.",

keywords = "Control region, HIV, Hair, Mitochondrial DNA, Reverse transcriptase inhibitors",

author = "C. Robino and C. Colla and A. Biglino and M. Degioanni and S. Gino and C. Torre",

year = "2009",

month = jan,

doi = "10.1016/j.fsigss.2009.08.023",

language = "English",

volume = "2",

pages = "501--502",

journal = "Forensic Science International: Genetics Supplement Series",

issn = "1875-1768",

publisher = "Elsevier B.V.",

number = "1",

}

TY - JOUR

T1 - Forensic mitochondrial DNA analysis in HIV-infected patients treated with nucleoside reverse transcriptase inhibitors

AU - Robino, C.

AU - Colla, C.

AU - Biglino, A.

AU - Degioanni, M.

AU - Gino, S.

AU - Torre, C.

PY - 2009/1

Y1 - 2009/1

N2 - Hypervariable regions HV1 and HV2 of the mitochondrial DNA control region were sequenced in pre-therapy (serum) and post-therapy (saliva, hair) biological samples collected from HIV-infected patients (n = 13) treated with nucleoside reverse transcriptase inhibitors (NRTIs). Occurrence of length/point heteroplasmic mutations as a consequence of treatment with NRTIs was evaluated. The observed rate of length heteroplasmy in the analyzed samples was consistent with values previously reported in untreated subjects, whereas no evidence of point heteroplasmy in post-treatment tissue samples was seen.

AB - Hypervariable regions HV1 and HV2 of the mitochondrial DNA control region were sequenced in pre-therapy (serum) and post-therapy (saliva, hair) biological samples collected from HIV-infected patients (n = 13) treated with nucleoside reverse transcriptase inhibitors (NRTIs). Occurrence of length/point heteroplasmic mutations as a consequence of treatment with NRTIs was evaluated. The observed rate of length heteroplasmy in the analyzed samples was consistent with values previously reported in untreated subjects, whereas no evidence of point heteroplasmy in post-treatment tissue samples was seen.

KW - Control region

KW - HIV

KW - Hair

KW - Mitochondrial DNA

KW - Reverse transcriptase inhibitors

UR - http://www.scopus.com/inward/record.url?scp=70649112203&partnerID=8YFLogxK

U2 - 10.1016/j.fsigss.2009.08.023

DO - 10.1016/j.fsigss.2009.08.023

M3 - Article

AN - SCOPUS:70649112203

SN - 1875-1768

VL - 2

SP - 501

EP - 502

JO - Forensic Science International: Genetics Supplement Series

JF - Forensic Science International: Genetics Supplement Series

IS - 1

ER -

Forensic mitochondrial DNA analysis in HIV-infected patients treated with nucleoside reverse transcriptase inhibitors

Abstract

OSS delle Nazioni Unite

Accesso al documento

Altri file e collegamenti

Fingerprint

Cita questo