Abstract
Human neutrophils, having been activated by the chemotactic peptide N-formylmethionyl-leucyl-phenylalanine (FMLP), evoke histamine release from rat serosal mast cells. The release is dependent on FMLP concentration and it can be inhibited by disodium cromoglycate and by a flavonoid, silymarin, which displays free radical scavenging properties. Silymarin inhibition of neutrophil-mediated histamine release is dose-dependent. These results further stress the concept of a neutrophil-mast cell interaction, which may be involved in inflammatory processes.
Lingua originale | Inglese |
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pagine (da-a) | 155-158 |
Numero di pagine | 4 |
Rivista | Agents and Actions |
Volume | 18 |
Numero di pubblicazione | 1-2 |
DOI | |
Stato di pubblicazione | Pubblicato - apr 1986 |
Pubblicato esternamente | Sì |