FMLP-activated neutrophils evoke histamine release from mast cells

R. Fantozzi, S. Brunelleschi, A. Rubino, S. Tarli, E. Masini, P. F. Mannaioni

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

Human neutrophils, having been activated by the chemotactic peptide N-formylmethionyl-leucyl-phenylalanine (FMLP), evoke histamine release from rat serosal mast cells. The release is dependent on FMLP concentration and it can be inhibited by disodium cromoglycate and by a flavonoid, silymarin, which displays free radical scavenging properties. Silymarin inhibition of neutrophil-mediated histamine release is dose-dependent. These results further stress the concept of a neutrophil-mast cell interaction, which may be involved in inflammatory processes.

Lingua originaleInglese
pagine (da-a)155-158
Numero di pagine4
RivistaAgents and Actions
Volume18
Numero di pubblicazione1-2
DOI
Stato di pubblicazionePubblicato - apr 1986
Pubblicato esternamente

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