TY - GEN
T1 - Flexible, efficient and interactive retrieval for supporting in-silico studies of endobacteria
AU - Montani, Stefania
AU - Leonardi, Giorgio
AU - Ghignone, Stefano
AU - Lanfranco, Luisa
PY - 2011
Y1 - 2011
N2 - Studying the interactions between arbuscular mycorrhizal fungi (AMFs) and their symbiotic endobacteria has potentially strong impacts on the development of new biotechnology applications. The analysis of genomic data and syntenies is a key technique for acquiring information about phylogenetic relationships and metabolic functions of such organisms. In this paper we describe a case-based retrieval tool, which supports customized comparative genomics searches, and which is part of a modular architecture meant to support insilico genome sequence analysis, being developed within the project BIOBITS. From a methodological viewpoint, the tool takes advantage of an abstraction technique similar to Temporal Abstractions, thus allowing to neglect un-relevant details. Retrieval is made flexible by the use of such multi-level abstractions, and efficient by the use of proper taxonomical index structures. Moreover, end-users are allowed to progressively relax or refine their queries, in an interactive way. A case study taken from the application domain is used to illustrate the approach.
AB - Studying the interactions between arbuscular mycorrhizal fungi (AMFs) and their symbiotic endobacteria has potentially strong impacts on the development of new biotechnology applications. The analysis of genomic data and syntenies is a key technique for acquiring information about phylogenetic relationships and metabolic functions of such organisms. In this paper we describe a case-based retrieval tool, which supports customized comparative genomics searches, and which is part of a modular architecture meant to support insilico genome sequence analysis, being developed within the project BIOBITS. From a methodological viewpoint, the tool takes advantage of an abstraction technique similar to Temporal Abstractions, thus allowing to neglect un-relevant details. Retrieval is made flexible by the use of such multi-level abstractions, and efficient by the use of proper taxonomical index structures. Moreover, end-users are allowed to progressively relax or refine their queries, in an interactive way. A case study taken from the application domain is used to illustrate the approach.
KW - Case-based reasoning
KW - Comparative genomics
KW - Flexible and interactive retrieval
UR - http://www.scopus.com/inward/record.url?scp=84855784221&partnerID=8YFLogxK
U2 - 10.1109/ICTAI.2011.12
DO - 10.1109/ICTAI.2011.12
M3 - Conference contribution
AN - SCOPUS:84855784221
SN - 9780769545967
T3 - Proceedings - International Conference on Tools with Artificial Intelligence, ICTAI
SP - 17
EP - 24
BT - Proceedings - 2011 23rd IEEE International Conference on Tools with Artificial Intelligence, ICTAI 2011
T2 - 23rd IEEE International Conference on Tools with Artificial Intelligence, ICTAI 2011
Y2 - 7 November 2011 through 9 November 2011
ER -