Flavonoid oligoglycosides from Ophioglossum vulgatum L. Having wound healing properties

Marco Clericuzio, Stefano Tinello, Bruno Burlando, Elia Ranzato, Simona Martinotti, Laura Cornara, Arianna La Rocca

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

Two new glycosylated and acylated flavonols, viz. quercetin-3-O-[(6- caffeoyl)-β-glucopyranosyl (1→3) α-rhamnopyranoside]-7-O- α-rhamnopyranoside (2), and kaempferol-3-O-[(6-caffeoyl)-β- glucopyranosyl (1→3) α-rhamnopyranoside]-7-O-α-rhamnopyranoside (3), together with the known quercetin-3-O-methyl ether (1), were isolated from the aerial parts of the fern Ophioglossum vulgatum L. Their structures were established by means of 1D and 2D NMR spectra, as well as ESI-MS and ESI-HRMS spectra. Compounds 1-3 were all found to be active in scratch-wound healing assays on keratinocytes, with 3 being the most active one and showing maximum activity at 20μM.

Lingua originaleInglese
pagine (da-a)1639-1644
Numero di pagine6
RivistaPlanta Medica
Volume78
Numero di pubblicazione15
DOI
Stato di pubblicazionePubblicato - 2012

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