Flavonoid-induced autophagy in hormone sensitive breast cancer cells

Elisa Brunelli; Giulia Pinton; Paolo Bellini; Alberto Minassi; Giovanni Appendino; Laura Moro

doi:10.1016/j.fitote.2009.04.002

Flavonoid-induced autophagy in hormone sensitive breast cancer cells

Elisa Brunelli, Giulia Pinton, Paolo Bellini, Alberto Minassi, Giovanni Appendino, Laura Moro

Dipartimento di Scienze del Farmaco

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

The activity of 8-prenylapigenin (8-PA) and its 3'-methoxylated analogue isocannflavin B (IsoB) was investigated in estrogen-dependent T47-D and estrogen-independent MDA-MB-231 human breast cancer cell lines. 8-PA showed a biphasic effect on T47-D cell proliferation, while no significant effect was observed on MDA-MB-231 cells. Conversely, IsoB exhibited only an inhibitory effect on T47-D cell proliferation, accompanied by the appearance of an intense intracytoplasmic vacuolization of autophagic origin. Moreover, biochemical analysis showed that IsoB reduced Akt phosphorylation and p21^Cip1 expression in T47-D cells. These data show that the prenylflavone moiety is a versatile platform for the induction and modulation of bioactivity.

Lingua originale	Inglese
pagine (da-a)	327-332
Numero di pagine	6
Rivista	Fitoterapia
Volume	80
Numero di pubblicazione	6
DOI	https://doi.org/10.1016/j.fitote.2009.04.002
Stato di pubblicazione	Pubblicato - set 2009

OSS delle Nazioni Unite

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10.1016/j.fitote.2009.04.002

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title = "Flavonoid-induced autophagy in hormone sensitive breast cancer cells",

abstract = "The activity of 8-prenylapigenin (8-PA) and its 3'-methoxylated analogue isocannflavin B (IsoB) was investigated in estrogen-dependent T47-D and estrogen-independent MDA-MB-231 human breast cancer cell lines. 8-PA showed a biphasic effect on T47-D cell proliferation, while no significant effect was observed on MDA-MB-231 cells. Conversely, IsoB exhibited only an inhibitory effect on T47-D cell proliferation, accompanied by the appearance of an intense intracytoplasmic vacuolization of autophagic origin. Moreover, biochemical analysis showed that IsoB reduced Akt phosphorylation and p21Cip1 expression in T47-D cells. These data show that the prenylflavone moiety is a versatile platform for the induction and modulation of bioactivity.",

keywords = "8-Prenylapigenin, 8-Prenylnaringenin, Autophagy, Breast cancer cells, Cell signalling, Isocannflavin B",

author = "Elisa Brunelli and Giulia Pinton and Paolo Bellini and Alberto Minassi and Giovanni Appendino and Laura Moro",

note = "Funding Information: This work was supported by Miur and Regione Piemonte.",

year = "2009",

month = sep,

doi = "10.1016/j.fitote.2009.04.002",

language = "English",

volume = "80",

pages = "327--332",

journal = "Fitoterapia",

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TY - JOUR

T1 - Flavonoid-induced autophagy in hormone sensitive breast cancer cells

AU - Brunelli, Elisa

AU - Pinton, Giulia

AU - Bellini, Paolo

AU - Minassi, Alberto

AU - Appendino, Giovanni

AU - Moro, Laura

N1 - Funding Information: This work was supported by Miur and Regione Piemonte.

PY - 2009/9

Y1 - 2009/9

N2 - The activity of 8-prenylapigenin (8-PA) and its 3'-methoxylated analogue isocannflavin B (IsoB) was investigated in estrogen-dependent T47-D and estrogen-independent MDA-MB-231 human breast cancer cell lines. 8-PA showed a biphasic effect on T47-D cell proliferation, while no significant effect was observed on MDA-MB-231 cells. Conversely, IsoB exhibited only an inhibitory effect on T47-D cell proliferation, accompanied by the appearance of an intense intracytoplasmic vacuolization of autophagic origin. Moreover, biochemical analysis showed that IsoB reduced Akt phosphorylation and p21Cip1 expression in T47-D cells. These data show that the prenylflavone moiety is a versatile platform for the induction and modulation of bioactivity.

AB - The activity of 8-prenylapigenin (8-PA) and its 3'-methoxylated analogue isocannflavin B (IsoB) was investigated in estrogen-dependent T47-D and estrogen-independent MDA-MB-231 human breast cancer cell lines. 8-PA showed a biphasic effect on T47-D cell proliferation, while no significant effect was observed on MDA-MB-231 cells. Conversely, IsoB exhibited only an inhibitory effect on T47-D cell proliferation, accompanied by the appearance of an intense intracytoplasmic vacuolization of autophagic origin. Moreover, biochemical analysis showed that IsoB reduced Akt phosphorylation and p21Cip1 expression in T47-D cells. These data show that the prenylflavone moiety is a versatile platform for the induction and modulation of bioactivity.

KW - 8-Prenylapigenin

KW - 8-Prenylnaringenin

KW - Autophagy

KW - Breast cancer cells

KW - Cell signalling

KW - Isocannflavin B

UR - http://www.scopus.com/inward/record.url?scp=67650450192&partnerID=8YFLogxK

U2 - 10.1016/j.fitote.2009.04.002

DO - 10.1016/j.fitote.2009.04.002

M3 - Article

SN - 0367-326X

VL - 80

SP - 327

EP - 332

JO - Fitoterapia

JF - Fitoterapia

IS - 6

ER -

Flavonoid-induced autophagy in hormone sensitive breast cancer cells

Abstract

OSS delle Nazioni Unite

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