TY - JOUR
T1 - Filling the Gap: Chemistry of 3,5-Bis(trifluoromethyl)-1H-pyrazoles
AU - Maspero, A
AU - GIOVENZANA, Giovanni Battista
AU - Monticelli, D
AU - Tagliapietra, S
AU - Palmisano, G
AU - Penoni, A.
N1 - Funding Information:
The present work was generously supported by Ministero dell’Istruzione, dell’Università e della Ricerca (PRIN 2008) (prot 2008M3Y5WX) ( Ottimizzazione della sintesi di molecole eterocicliche e carbocicliche mediante l’uso di procedure non convenzionali ). The reviewers’ comments contributed to a significant improvement of the manuscript. Appendix A
PY - 2012
Y1 - 2012
N2 - Pyrazoles represent important building blocks for the preparation of bioactive compounds and a large variety of materials, due to their rich coordination chemistry. Unusual and interesting properties may be imparted to molecules embodying highly fluorinated pyrazoles, but to date only few examples of polyfluorinated pyrazoles have been described. In this work we report an improved preparation of 3,5-bis(trifluoromethyl)-1H-pyrazole, the subsequent transformation into hitherto unknown 4-functionalized (F, Cl, Br, I, NO2, NH2) derivatives and the evaluation of selected chemical and physical properties of these compounds.
AB - Pyrazoles represent important building blocks for the preparation of bioactive compounds and a large variety of materials, due to their rich coordination chemistry. Unusual and interesting properties may be imparted to molecules embodying highly fluorinated pyrazoles, but to date only few examples of polyfluorinated pyrazoles have been described. In this work we report an improved preparation of 3,5-bis(trifluoromethyl)-1H-pyrazole, the subsequent transformation into hitherto unknown 4-functionalized (F, Cl, Br, I, NO2, NH2) derivatives and the evaluation of selected chemical and physical properties of these compounds.
UR - https://iris.uniupo.it/handle/11579/13685
U2 - 10.1016/j.jfluchem.2012.04.003
DO - 10.1016/j.jfluchem.2012.04.003
M3 - Article
SN - 0022-1139
VL - 139
SP - 53
EP - 57
JO - Journal of Fluorine Chemistry
JF - Journal of Fluorine Chemistry
ER -