Ferrole-estradiol complex as a test for receptor dimerization

Domenico Osella; Giorgia Dutto; Carlo Nervi; Michael J. McGlinchey; Anne Vessières; Gérard Jaouen

doi:10.1016/S0022-328X(96)06832-5

Ferrole-estradiol complex as a test for receptor dimerization

Domenico Osella
, Giorgia Dutto
, Carlo Nervi
, Michael J. McGlinchey
, Anne Vessières
, Gérard Jaouen

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

We describe the synthesis of a structure based on the iron carbonyl mediated head-to-head coupling of two molecules of 17α-ethynylestradiol that leads ultimately to a ferrole. This compound was prepared with the aim of probing the mechanism of action of the estradiol receptor; spectroscopic, molecular modelling and biochemical studies are reported. The estradiol-ferrole cluster retains a weak, but not zero, affinity for the estradiol receptor. There is reversible binding to the receptor, and this is rationalized in terms of the pK_R+ value of -13.1 found for the bioorganometallic complex.

Lingua originale	Inglese
pagine (da-a)	97-102
Numero di pagine	6
Rivista	Journal of Organometallic Chemistry
Volume	533
Numero di pubblicazione	1-2
DOI	https://doi.org/10.1016/S0022-328X(96)06832-5
Stato di pubblicazione	Pubblicato - 15 apr 1997
Pubblicato esternamente	Sì

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10.1016/S0022-328X(96)06832-5

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title = "Ferrole-estradiol complex as a test for receptor dimerization",

abstract = "We describe the synthesis of a structure based on the iron carbonyl mediated head-to-head coupling of two molecules of 17α-ethynylestradiol that leads ultimately to a ferrole. This compound was prepared with the aim of probing the mechanism of action of the estradiol receptor; spectroscopic, molecular modelling and biochemical studies are reported. The estradiol-ferrole cluster retains a weak, but not zero, affinity for the estradiol receptor. There is reversible binding to the receptor, and this is rationalized in terms of the pKR+ value of -13.1 found for the bioorganometallic complex.",

keywords = "Bioorganometallic chemistry, Estradiol receptor, Iron, Molecular recognition",

author = "Domenico Osella and Giorgia Dutto and Carlo Nervi and McGlinchey, \{Michael J.\} and Anne Vessi{\`e}res and G{\'e}rard Jaouen",

note = "Funding Information: We thank the European Union for financial support (Contract ERBC1PA ACT 930027) and Dr. M. Vincenfi (Department of Analytical Chemistry, University of Torino) for DCI mass spectra.",

year = "1997",

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doi = "10.1016/S0022-328X(96)06832-5",

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TY - JOUR

T1 - Ferrole-estradiol complex as a test for receptor dimerization

AU - Osella, Domenico

AU - Dutto, Giorgia

AU - Nervi, Carlo

AU - McGlinchey, Michael J.

AU - Vessières, Anne

AU - Jaouen, Gérard

N1 - Funding Information: We thank the European Union for financial support (Contract ERBC1PA ACT 930027) and Dr. M. Vincenfi (Department of Analytical Chemistry, University of Torino) for DCI mass spectra.

PY - 1997/4/15

Y1 - 1997/4/15

N2 - We describe the synthesis of a structure based on the iron carbonyl mediated head-to-head coupling of two molecules of 17α-ethynylestradiol that leads ultimately to a ferrole. This compound was prepared with the aim of probing the mechanism of action of the estradiol receptor; spectroscopic, molecular modelling and biochemical studies are reported. The estradiol-ferrole cluster retains a weak, but not zero, affinity for the estradiol receptor. There is reversible binding to the receptor, and this is rationalized in terms of the pKR+ value of -13.1 found for the bioorganometallic complex.

AB - We describe the synthesis of a structure based on the iron carbonyl mediated head-to-head coupling of two molecules of 17α-ethynylestradiol that leads ultimately to a ferrole. This compound was prepared with the aim of probing the mechanism of action of the estradiol receptor; spectroscopic, molecular modelling and biochemical studies are reported. The estradiol-ferrole cluster retains a weak, but not zero, affinity for the estradiol receptor. There is reversible binding to the receptor, and this is rationalized in terms of the pKR+ value of -13.1 found for the bioorganometallic complex.

KW - Bioorganometallic chemistry

KW - Estradiol receptor

KW - Iron

KW - Molecular recognition

UR - https://www.scopus.com/pages/publications/0031569713

U2 - 10.1016/S0022-328X(96)06832-5

DO - 10.1016/S0022-328X(96)06832-5

M3 - Article

SN - 0022-328X

VL - 533

SP - 97

EP - 102

JO - Journal of Organometallic Chemistry

JF - Journal of Organometallic Chemistry

IS - 1-2

ER -

Ferrole-estradiol complex as a test for receptor dimerization

Abstract

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