Feature- and Order-Based Timing Representations in the Frontal Cortex

ALDO GENOVESIO, Satoshi Tsujimoto, Steven P. Wise

Risultato della ricerca: Contributo su rivistaArticolo in rivista

Abstract

We examined activity in the frontal cortex as monkeys performed a duration-discrimination task. Two stimuli, one red and the other blue, appeared sequentially on a video screen-in either order. Later, both stimuli reappeared, and to receive a reward the monkeys had to choose the stimulus that had lasted longer during its initial presentation. Some neurons encoded stimulus duration, but a larger number of cells represented their relative duration, which was encoded in three ways: whether the first or second stimulus had lasted longer; whether the red or blue stimulus had lasted longer; or, less commonly, as the difference between the two durations. As the monkeys' choice approached, the signal encoding which stimulus (red or blue) had lasted longer increased as the order-based signal dissipated. By representing stimulus durations and relative durations-both bound to stimulus features and event order-the frontal cortex could contribute to both temporal perception and episodic memory. © 2009 Elsevier Inc. All rights reserved.
Lingua originaleInglese
pagine (da-a)254-266
Numero di pagine13
RivistaNeuron
Volume63
Numero di pubblicazione2
DOI
Stato di pubblicazionePubblicato - 2009

Keywords

  • monkeys
  • timing
  • prefrontal cortex

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