Fateful music from a talented orchestra with a wicked conductor: Connection between oncogenic BRAF, ER stress, and autophagy in human melanoma

Paola Giglio; Gian Maria Fimia; Penny E. Lovat; Mauro Piacentini; Marco Corazzari

doi:10.4161/23723556.2014.995016

Fateful music from a talented orchestra with a wicked conductor: Connection between oncogenic BRAF, ER stress, and autophagy in human melanoma

Paola Giglio
, Gian Maria Fimia
, Penny E. Lovat
, Mauro Piacentini
, Marco Corazzari

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Autophagy and endoplasmic reticulum (ER) stress are involved in the development, progression, and chemoresistance of melanoma. We recently reported that oncogenic serine/threonine-protein kinase BRAF induces chronic ER stress, hence increasing baseline autophagy and promoting chemoresistance. The attenuation of ER stress restores basal autophagic activity and resensitizes melanoma cells to apoptosis.

Lingua originale	Inglese
Numero di articolo	e995016
Rivista	Molecular and Cellular Oncology
Volume	2
Numero di pubblicazione	3
DOI	https://doi.org/10.4161/23723556.2014.995016
Stato di pubblicazione	Pubblicato - 3 lug 2015
Pubblicato esternamente	Sì

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title = "Fateful music from a talented orchestra with a wicked conductor: Connection between oncogenic BRAF, ER stress, and autophagy in human melanoma",

abstract = "Autophagy and endoplasmic reticulum (ER) stress are involved in the development, progression, and chemoresistance of melanoma. We recently reported that oncogenic serine/threonine-protein kinase BRAF induces chronic ER stress, hence increasing baseline autophagy and promoting chemoresistance. The attenuation of ER stress restores basal autophagic activity and resensitizes melanoma cells to apoptosis.",

keywords = "BRAF, ER stress, autophagy, cancer, melanoma",

author = "Paola Giglio and Fimia, \{Gian Maria\} and Lovat, \{Penny E.\} and Mauro Piacentini and Marco Corazzari",

note = "Publisher Copyright: {\textcopyright} 2015, {\textcopyright} 2015 The Author(s). Published with license by Taylor \& Francis Group, LLC. {\textcopyright} 2015, {\textcopyright} Paola Giglio, Gian Maria Fimia, Penny E Lovat, Mauro Piacentini, and Marco Corazzari.",

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doi = "10.4161/23723556.2014.995016",

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AU - Giglio, Paola

AU - Fimia, Gian Maria

AU - Lovat, Penny E.

AU - Piacentini, Mauro

AU - Corazzari, Marco

N1 - Publisher Copyright: © 2015, © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC. © 2015, © Paola Giglio, Gian Maria Fimia, Penny E Lovat, Mauro Piacentini, and Marco Corazzari.

PY - 2015/7/3

Y1 - 2015/7/3

N2 - Autophagy and endoplasmic reticulum (ER) stress are involved in the development, progression, and chemoresistance of melanoma. We recently reported that oncogenic serine/threonine-protein kinase BRAF induces chronic ER stress, hence increasing baseline autophagy and promoting chemoresistance. The attenuation of ER stress restores basal autophagic activity and resensitizes melanoma cells to apoptosis.

AB - Autophagy and endoplasmic reticulum (ER) stress are involved in the development, progression, and chemoresistance of melanoma. We recently reported that oncogenic serine/threonine-protein kinase BRAF induces chronic ER stress, hence increasing baseline autophagy and promoting chemoresistance. The attenuation of ER stress restores basal autophagic activity and resensitizes melanoma cells to apoptosis.

KW - BRAF

KW - ER stress

KW - autophagy

KW - cancer

KW - melanoma

U2 - 10.4161/23723556.2014.995016

DO - 10.4161/23723556.2014.995016

M3 - Article

SN - 2372-3556

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JO - Molecular and Cellular Oncology

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M1 - e995016

ER -

Fateful music from a talented orchestra with a wicked conductor: Connection between oncogenic BRAF, ER stress, and autophagy in human melanoma

Abstract

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