Fateful music from a talented orchestra with a wicked conductor. Oncogenic BRAF, ER stress and autophagy connection in human melanoma

P Giglio; Fimia GM; Lovat PE; M Piacentini; MARCO CORAZZARI

doi:10.4161/23723556.2014.995016

Fateful music from a talented orchestra with a wicked conductor. Oncogenic BRAF, ER stress and autophagy connection in human melanoma

P Giglio, Fimia GM, Lovat PE, M Piacentini, MARCO CORAZZARI

Dipartimento di Scienze della Salute

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Autophagy and endoplasmic reticulum (ER) stress are involved in the development, progression, and chemoresistance of melanoma. We recently reported that oncogenic serine/threonine-protein kinase BRAF induces chronic ER stress, hence increasing baseline autophagy and promoting chemoresistance. The attenuation of ER stress restores basal autophagic activity and resensitizes melanoma cells to apoptosis.

Lingua originale	Inglese
Rivista	Molecular and Cellular Oncology
DOI	https://doi.org/10.4161/23723556.2014.995016
Stato di pubblicazione	Pubblicato - 2015

OSS delle Nazioni Unite

Questo processo contribuisce al raggiungimento dei seguenti obiettivi di sviluppo sostenibile

Accesso al documento

10.4161/23723556.2014.995016

http://hdl.handle.net/11579/80768

Altri file e collegamenti

handle

Cita questo

@article{443ec7b16a574898ac33f87231b86db9,

title = "Fateful music from a talented orchestra with a wicked conductor. Oncogenic BRAF, ER stress and autophagy connection in human melanoma",

abstract = "Autophagy and endoplasmic reticulum (ER) stress are involved in the development, progression, and chemoresistance of melanoma. We recently reported that oncogenic serine/threonine-protein kinase BRAF induces chronic ER stress, hence increasing baseline autophagy and promoting chemoresistance. The attenuation of ER stress restores basal autophagic activity and resensitizes melanoma cells to apoptosis.",

author = "P Giglio and Fimia GM and Lovat PE and M Piacentini and MARCO CORAZZARI",

note = "Publisher Copyright: {\textcopyright} 2015, {\textcopyright} 2015 The Author(s). Published with license by Taylor \& Francis Group, LLC. {\textcopyright} 2015, {\textcopyright} Paola Giglio, Gian Maria Fimia, Penny E Lovat, Mauro Piacentini, and Marco Corazzari.",

year = "2015",

doi = "10.4161/23723556.2014.995016",

language = "English",

journal = "Molecular and Cellular Oncology",

issn = "2372-3556",

publisher = "Taylor and Francis Ltd.",

}

TY - JOUR

T1 - Fateful music from a talented orchestra with a wicked conductor. Oncogenic BRAF, ER stress and autophagy connection in human melanoma

AU - Giglio, P

AU - GM, Fimia

AU - PE, Lovat

AU - Piacentini, M

AU - CORAZZARI, MARCO

N1 - Publisher Copyright: © 2015, © 2015 The Author(s). Published with license by Taylor & Francis Group, LLC. © 2015, © Paola Giglio, Gian Maria Fimia, Penny E Lovat, Mauro Piacentini, and Marco Corazzari.

PY - 2015

Y1 - 2015

N2 - Autophagy and endoplasmic reticulum (ER) stress are involved in the development, progression, and chemoresistance of melanoma. We recently reported that oncogenic serine/threonine-protein kinase BRAF induces chronic ER stress, hence increasing baseline autophagy and promoting chemoresistance. The attenuation of ER stress restores basal autophagic activity and resensitizes melanoma cells to apoptosis.

AB - Autophagy and endoplasmic reticulum (ER) stress are involved in the development, progression, and chemoresistance of melanoma. We recently reported that oncogenic serine/threonine-protein kinase BRAF induces chronic ER stress, hence increasing baseline autophagy and promoting chemoresistance. The attenuation of ER stress restores basal autophagic activity and resensitizes melanoma cells to apoptosis.

UR - https://iris.uniupo.it/handle/11579/80768

U2 - 10.4161/23723556.2014.995016

DO - 10.4161/23723556.2014.995016

M3 - Article

SN - 2372-3556

JO - Molecular and Cellular Oncology

JF - Molecular and Cellular Oncology

ER -

Fateful music from a talented orchestra with a wicked conductor. Oncogenic BRAF, ER stress and autophagy connection in human melanoma

Abstract

OSS delle Nazioni Unite

Accesso al documento

Altri file e collegamenti

Fingerprint

Cita questo